ABSTRACT
The authors report on 2 sisters with acute lymphoblastic leukemia diagnosed at age 30 months and 3.5 months. The younger one was referred 15 months after the first. The reason for reporting this case is family risk and also infant under 12 months, especially under 6 months, of age have extremely poor prognosis, but both sister are at present time on complete remission.
Subject(s)
Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Child, Preschool , Family Health , Female , Humans , Infant , Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis , Precursor Cell Lymphoblastic Leukemia-Lymphoma/etiology , Remission Induction , SiblingsABSTRACT
Ghosal-type hemato-diaphyseal dysplasia is a rare autosomal recessive disorder with distinctive diaphyseal and metaphyseal dysplasia of long bones and steroid-dependant anemia. The authors describe a 20-month-old girl who had had a severe transfusion-dependent anemia since late infancy and marked locomotion difficulties as a toddler. The diagnosis was established by X-ray bone survey. The anemia was treated with oral prednisolone. Since then, the patient has been doing well on steroid-maintenance therapy and has no more walking difficulties. The incidence of hemato-diaphyseal dysplasia in the Indian subcontinent and Middle East is notable.
