1.
Vestn Ross Akad Med Nauk
; (7): 32-6, 2007.
Article
in Russian
| MEDLINE
| ID: mdl-17722295
ABSTRACT
Natural antibodies possessing catalytic activity present a new group of biologically active substances that are found in various autoimmune diseases such as autoimmune thyroiditis, myocarditis, multiple sclerosis, and system lupus erythematosus. Presently, an interconnection between the activity of these antibodies and the extent of organic and tissue lesion in autoaggression have been revealed. Clinical use of catalytic antibodies as a diagnostic criterion to evaluate the severity of disease, a prognostic criterion of the risk of invalidization, and as a pathogenetic basis for medicamentous treatment of autoimmune process is a promising directions of study of the role of catalytic antibodies.
Subject(s)
Antibodies, Catalytic , Multiple Sclerosis/diagnosis , Myelin-Associated Glycoprotein/immunology , Nerve Fibers, Myelinated/pathology , Disease Progression , Humans , Multiple Sclerosis/immunology , Multiple Sclerosis/metabolism , Myelin-Associated Glycoprotein/metabolism , Nerve Fibers, Myelinated/metabolism , Prognosis , Severity of Illness Index
2.
Ter Arkh
; 79(4): 71-6, 2007.
Article
in Russian
| MEDLINE
| ID: mdl-17564024