ABSTRACT
Stages of modeling of polyetiological electrolyte nephropathy in rats are described. Morphological study confirmed the presence of interstitial and tubular disorders in rat kidneys. The model is intended for studies of the mechanisms underlying the formation, development, and correction of nephrological diseases.
Subject(s)
Disease Models, Animal , Kidney Diseases/etiology , Kidney Diseases/pathology , Animals , Electrolytes , Magnesium Deficiency/complications , Male , Potassium Deficiency/complications , Rats , Rats, Wistar , Sodium Chloride/toxicityABSTRACT
AIM: To elucidate correlations between characteristics of lipid metabolism in patients with ischemic heart disease and their offsprings. MATERIAL: Patients with overt ischemic heart disease (probands, n=24, mean age 53-/+1.9 years), their first (n=25, mean age 25.7-/+1.8 years) and second generation (n=20, mean age 13.5-/+1.3 years) offsprings. METHODS: The following parameters were studied: levels of lipids, lipoproteins, native and modified serum apolipoproteins, composition of phospholipids and fatty acids in blood erythrocytes, content of intracellular cholesterol in human aortic intima smooth muscle cells in vitro. RESULTS AND CONCLUSION: Members of a family had similar characteristics of lipid metabolism. According to levels of lipids, characteristics of composition of phospholipids and fatty acids in erythrocytes, presence of atherogenic factors in blood serum three variants of family traits of disturbances of lipid metabolism were distinguished.
Subject(s)
Apolipoproteins/blood , Apolipoproteins/genetics , Lipoproteins/blood , Lipoproteins/genetics , Myocardial Ischemia/blood , Myocardial Ischemia/genetics , Adult , Cluster Analysis , Female , Humans , MaleABSTRACT
Stages of reproduction of a polyetiological model of coronary failure in rats are described. The model is based on the development of electrolyte steroid cardiopathy. Morphological studies confirmed the presence of degenerative changes in rat myocardium and coronary vessels. The model is intended for studies of the development and remission of cardiac diseases.
Subject(s)
Cardiomyopathy, Dilated/physiopathology , Disease Models, Animal , Animal Nutritional Physiological Phenomena , Animals , Body Weight , Cardiomyopathy, Dilated/pathology , Electrolytes/metabolism , Male , Myocardium/pathology , Rats , Rats, Wistar , Salts/pharmacologyABSTRACT
Clinicobiochemical parameters and factors of risk of ischemic heart disease in patients with cardiorespiratory diseases (CRD) were examined for correlations. The risk factors, impairment of lipid spectrum and antioxidant defense were assessed in patients aged 27 to 70 years with CRD. The patients were divided into three groups: patients with chronic nonspecific pulmonary diseases (CNSPD), ischemic heart disease patients (IHD), those with CNSPD plus IHD. The results suggest that in CNSPD patients such risk factors as smoking, low physical activity, stress, arterial hypertension, hereditary predisposition to IHD occurred in more than 50% of cases. Compared to IHD patients, these patients' dyslipoproteinemia was characterized by greater frequency of hypercholesterolemia and less frequency of hypoalphacholesterolemia. Combination of atherosclerosis with CNSPD aggravates the course of vascular disorders.