ABSTRACT
Menopause is a crucial time in the life of any women. Perhaps the severity of menopausal symptoms defines further state of female health. The aim of the study is to assess changes of cardiovascular system during perimenopause and the connection between this changes and severity of menopausal symptoms. The data of 155 premenopausal women without coronary heart disease were analyzed. To assess women hormonal state follicle stimulating hormone was measured. The severity of menopausal symptoms was evaluated with the help of Kupperman questionnaire form in Uvarova modification. All women were divided into two groups according to follicle stimulating hormone. Women with follicle stimulating hormone higher 30 MU/l were classified as postmenopausal. It was shown that groups of pre - and postmenopausal women significantly differ in age, progesterone, follicle stimulating hormone level, and SCORE. The severity of menopausal symptoms was the same in studied groups. Regression analysis revealed that severity of menopausal symptoms depended on systolic blood pressure, follicle stimulating hormone level, progesterone level. The link between cardiovascular risk (SCORE) and follicle stimulating hormone, NO2, ApoÐ1, and severity of menopausal symptoms was found.
