ABSTRACT
In a randomized prospective clinical trial in 128 patients undergoing radical surgical resection of primary colorectal cancer, 63 patients received intravenous fluorouracil (5-FU) in two courses, four and eight weeks after surgery; 65 controls received no chemotherapy. The duration of follow-up exceeded five years in all cases, and 28 patients have died in each group. Recurrent disease was present in 26 5-FU patients (41.2 percent) and in 22 controls (33.9 percent). There is no evidence that short-term 5-FU therapy was of significant value in the chemoprophylaxis of colorectal cancer.
Subject(s)
Colonic Neoplasms/prevention & control , Fluorouracil/therapeutic use , Neoplasm Recurrence, Local/prevention & control , Rectal Neoplasms/prevention & control , Aged , Clinical Trials as Topic , Colonic Neoplasms/mortality , Female , Follow-Up Studies , Humans , Male , Neoplasm Recurrence, Local/mortality , Prospective Studies , Random Allocation , Rectal Neoplasms/mortalityABSTRACT
The recurrence of multiple inflammatory fibroid polyps is reported in three generations of a Devon family. Only one female in each has been affected in a direct line of descent. The grandmother has had nine polyps resected over 11 years, the mother seven over 18 years, and the daughter six over six years. None of the patients or their relatives are known to have any allergies, dietary fads, or gastrointestinal infections. Chromosome studies have been normal in two patients. No cancer risk has been identified. Conventional histology, electron microscopy, and immunohistology suggest that the lesion is a self-limiting proliferation of histiocytes; the initiating event or stimulus remains unknown. A genetic factor is likely to operate in this unique family which is probably polygenic and multifactorial in nature.
Subject(s)
Fibroma/genetics , Gastrointestinal Neoplasms/genetics , Adult , Aged , Female , Fibroma/ultrastructure , Gastrointestinal Neoplasms/ultrastructure , Humans , Microscopy, Electron , Middle Aged , Pedigree , Recurrence , SyndromeABSTRACT
Seven patients are reported with acute appendicitis occurring in an external hernial sac. The average age was 69 years. In 4 cases the site was a right femoral hernia and in 3 a right indirect inguinal hernia. In no case was the correct diagnosis made before operation. Recovery was uneventful apart from wound infection in 3 cases.
Subject(s)
Appendicitis/complications , Hernia, Femoral/complications , Hernia, Inguinal/complications , Adult , Aged , Appendectomy , Appendicitis/surgery , Female , Humans , Male , Middle AgedABSTRACT
Direct communication between aorta and intestinal lumen, whether spontaneous (primary) or postoperative (secondary), is a rate and frequently lethal cause of gastrointestinal haemorrhage. This paper records what is believed to be a unique occurrence in the survival of a patient who following surgery for ruptured aortic aneurysm, not only developed an aorto-duodenal but subsequently an aorto-colonic fistula over a span of 5 years.
