ABSTRACT
The relative percentage of type III to type I collagen, the ratio of alpha 1(I) to alpha 2(I) collagen chains and the ratio of dimers (beta-chains) to monomers (alpha-chains) in type I collagen have been measured in solubilized collagen fractions from keloids and hypertrophic scars aged about 1-7 years after burn. In tissue samples the content of crosslink with structure of pyridinoline were analyzed and expressed as mole of crosslink per mole of collagen. A comparison between hypertrophic and keloid scars has shown that the young (about 1 year) hypertrophic scars have higher ratios alpha 1(I)/alpha 2(I) and beta 11 + beta 12/alpha 1(I) + alpha 2(I). The increased proportion of beta-chains in the younger hypertrophic scars approximated to the same level as in normal skin within 7 years after lesion. There was no decrease in the ratio dimers/monomers of collagen type I with age of keloid scar tissue. The relative amount of collagen type III in young keloid scars was found decreased as compared to age-matched hypertrophic scars (13 +/- 3 and 17 +/- 7 respectively), but was similar in the older scars. The average pyridinoline crosslinks content per mole of collagen in keloids was 2 times as high as in hypertrophic scars. The data support the suggestion that general, as well as peculiar disturbances of collagen metabolism are involved in the development of keloids and hypertrophic scars.
Subject(s)
Cicatrix, Hypertrophic/metabolism , Collagen/chemistry , Keloid/metabolism , Amino Acids/chemistry , Child , Child, Preschool , Cicatrix, Hypertrophic/pathology , Collagen/metabolism , Humans , Infant , Keloid/pathology , Protein ConformationABSTRACT
An operation was performed in an 8-years-old girl suffering from a recessive dystrophic epidermolysis bullosa from birth complicated by a developed contracture and syndactyly of the both bones in order to eliminate these defects without using an autotransplant. The postoperative course was without complications, epithelialization developed by the end of the 3rd week. No recurrences were noted during 2 years.
Subject(s)
Contracture/surgery , Epidermolysis Bullosa Dystrophica/complications , Fingers/abnormalities , Fingers/surgery , Syndactyly/surgery , Child , Contracture/etiology , Female , Humans , Methods , Syndactyly/etiology , Transplantation, Autologous , Wound HealingABSTRACT
On the basis of expert estimation of 208 case records of the children, who died from thermal trauma, the structure and causes of lethality in burn shock, toxemia and septicotoxemia were studied. The organization and therapeutico-diagnostic errors were analysed. The concept of "critical burn" was defined for the children of different age.
Subject(s)
Burns/mortality , Adolescent , Burns/pathology , Child , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Male , Shock, Traumatic/mortalitySubject(s)
Dermatitis, Atopic/metabolism , Neurodermatitis/metabolism , Pyridoxine/metabolism , Urticaria/metabolism , Vitamin B 6 Deficiency/etiology , Adolescent , Child , Child, Preschool , Dermatitis, Atopic/complications , Female , Humans , Male , Neurodermatitis/complications , Urticaria/complicationsABSTRACT
A comparison of dimensions of the pelvis in healthy children (340) and children with developmental defects of the ano-rectal area (40) has shown all the dimensions to be altered in children with the congenital pathology which illustrates different degrees of underdevelopment of the anatomical structures of this field. The greatest deviation in the pelvis dimensions values was revealed in children of the older age group and appears to be an illustration of decreased trophic functions of the tissues.
