Subject(s)
Bone Density/physiology , Bone and Bones/metabolism , Lupus Erythematosus, Systemic/metabolism , Tomography, X-Ray Computed , Adult , Bone and Bones/diagnostic imaging , Disease Progression , Female , Follow-Up Studies , Humans , Lupus Erythematosus, Systemic/diagnostic imaging , Male , Prognosis , Severity of Illness IndexABSTRACT
Vertebral trabecular bone mineral density (BMD) was measured by quantitative computed tomography (QCT) in 1061 subjects (610 females and 451 males aged from 7 to 91 and from 12 to 89, respectively) with known history of diseases or taking medicines affecting bone metabolism. Peak BMD values in our patients were observed at the age of 20-29 years with further gradual decrement in men and more steep in women. Negative relationship between BMD and age was r = -0.991 for men and r = -0.968 for women. Analyzing BMD changes by decades we observed the largest decrement in men after 60 (13.1% for 60-69 and 14.1% for 70-79 years of age) and in women after 50 (22.5% for 50-59, 22.1% for 60-69 and 20.8% for 70-79 years) which was most probably due to decline in sex hormones production that is known to significantly influence bone metabolism. This was confirmed by BMD values three-phase approximation in women showing the lowest rate of calcium loss by trabecular bone in reproductive period (1.9 mg/cm3/yr) and the highest in perimenopause (3.98 mg/cm3/yr). Annual calcium loss in postmenopause was 2.22 mg/cm3.
Subject(s)
Aging/metabolism , Bone Density , Spine/metabolism , Adolescent , Adult , Aged , Child , Female , Humans , Male , Middle Aged , Reference Values , Russia , Spine/diagnostic imaging , Tomography, X-Ray ComputedABSTRACT
Treatment methods and outcomes have been analyzed for 313 children aged 9 months-14 years with respiratory papillomatosis (RP) admitted to ENT clinic in 1950-1995. Beginning from 1982 papillomas were removed by means of ultrasonic disintegration. A novel approach included extracorporeal detoxication and immunocorrection. 85% of patients responded to treatment with discrete plasmapheresis and T-activin. It is concluded that best treatment results were achieved in combination of conventional methods with advanced modalities such as extracorporeal detoxication and immunocorrection.
Subject(s)
Laryngeal Neoplasms/therapy , Papilloma/therapy , Adjuvants, Immunologic/therapeutic use , Adolescent , Child , Child, Preschool , Combined Modality Therapy , Humans , Infant , Laryngeal Neoplasms/surgery , Laser Therapy , Papilloma/surgery , Peptides/therapeutic use , Plasmapheresis , Respiration, Artificial , Thymus Extracts/therapeutic use , Tracheotomy , Ultrasonic TherapyABSTRACT
The study was made of microbiological and immunological aspects of antiinfectious resistance (AIR) in children with respiratory papillomatosis (RP). At admission to hospital RP patients exhibited dysbacteriosis of the upper respiratory tract and colon. Immunological and microbiological response to the infection recurrences was adequate. Interrelated immunological and microbiological indices in RP objectively reflect the course of the pathological process and may be used in objective assessment of the disease and choice of its treatment.
