Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Tissue Eng Part A ; 21(17-18): 2390-403, 2015 Sep.
Article in English | MEDLINE | ID: mdl-26094554

ABSTRACT

Tracheal stenosis is a life-threatening disease and current treatments include surgical reconstruction with autologous rib cartilage and the highly complex slide tracheoplasty surgical technique. We propose using a sustainable implant, composed of a tunable, fibrous scaffold with encapsulated chondrogenic growth factor (transforming growth factor-beta3 [TGF-ß3]) or seeded allogeneic rabbit bone marrow mesenchymal stromal cells (BMSCs). In vivo functionality of these constructs was determined by implanting them in induced tracheal defects in rabbits for 6 or 12 weeks. The scaffolds maintained functional airways in a majority of the cases, with the BMSC-seeded group having an improved survival rate and the Scaffold-only group having a higher occurrence of more patent airways as determined by microcomputed tomography. The BMSC group had a greater accumulation of inflammatory cells over the graft, while also exhibiting normal epithelium, subepithelium, and cartilage formation. Overall, it was concluded that a simple, acellular scaffold is a viable option for tracheal tissue engineering, with the intraoperative addition of cells being an optional variation to the scaffolds.


Subject(s)
Tissue Scaffolds/chemistry , Trachea/pathology , Transforming Growth Factor beta3/metabolism , Animals , Bronchoscopy , Collagen/metabolism , Image Processing, Computer-Assisted , Inflammation/pathology , Male , Neovascularization, Physiologic , Rabbits , Survival Analysis , Trachea/blood supply , Trachea/diagnostic imaging , X-Ray Microtomography
SELECTION OF CITATIONS
SEARCH DETAIL
...