[Prognosis of the thyroid carcinomas after surgery (author's transl)]. / Pronostic des cancers thyroïdiens extra-capsulaires opérés.

The authors review 140 cases and show the prime importance of the patient's age and the histological type in the prognosis of the operations of thyroid carcinoma (with the exception of solitary malignant cold nodule). The survival rate is higher with the papillary carcinoma of young patients, even though an extensive development of lymph nodes occurs, whereas metastases are encountered in the evolution of follicular carcinoma with increased risks. The anaplastic carcinoma which occurs mainly in aged people, is the worst of all. The medullary carcinoma is quite different from the others and is almost as malignant as the differentiated and anaplastic carcinomas. Surgery has to be adapted to anatomical lesions and requires the presence of an experienced histopathologist, the extension of the gland excision depending on the histological type and whether the isthmic area has been touched or not; in the same way a microscopic examination of lymph nodes, which are systematically excised, reveals whether a lymph nodes dissection has to be done at the same time. In this way extensive excisions together with their sequels can be avoided when the best prognosis can be forecasted with these lesions.

[Non-recurrent inferior laryngeal nerve (15 operative cases)]. / Le nerf laryngé inférieur non récurrent (à propos de quinze cas opératoires).

During surgery on the right thyroid lobe, 15 cases of non-recurrence of the inferior laryngeal nerve were observed, among which two types of equal frequency. Embryologic data explain why this abnormality is always associated with an abnormal origin of the right subclavian artery, directly from the aortic arch. The right subclavian artery generally passes behind the oesophagus in these cases. These 15 cases represent 0,79% of the 1889 cases studied during a short period (1971-1978).

Time dependent modifications in arterial flow in a transplanted pulmonary lobe.

Study of pulmonary arterial flow in the transplanted lung by means of an implanted ultrasonic flowmeter enables us: 1. To confirm results obtained by other methods (De Bono,8 Strider14 and Strandberg18): without specific treatment, rejection of graft causes increased peripheral resistances and the pulmonary arterial flow decreases progressively. 2. To prove by direct observation the existence in the treated animal of authentic precapillary shunts whose importance can cause the animal's death through functional disorder alone.

The determination of clioquinol in biological materials by extractive alkylation and gas-liquid chromatography.

Clioquinol, or 5-chloro-7-iodo-8-hydroxyquinoline (Vioform), and the internal standard, 5,7-dichloro-8-hydroxyquinoline are extracted from biological material in the form of their tetrahexylammonium salts into dichloromethane, where, in the presence of a methylating agent, both clioquinol and the standard are spontaneously transformed into their O-methyl derivatives. These derivatives can be purified by base-specific extraction and subsequently determined by gas chromatography; concentrations down to 10 ng per sample may be assayed. The method is compared with a previously reported procedure based on the O-acetyl derivatives.