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1.
Scand J Surg ; 109(1): 59-68, 2020 Mar.
Article in English | MEDLINE | ID: mdl-32192418

ABSTRACT

BACKGROUND: Chronic pancreatitis is a long-standing, inflammatory condition of the pancreas that leads to the progressive damage and loss of function of pancreatic parenchyma and to the development of possible locoregional and systemic medical complications. MATERIALS AND METHODS: In this review, we tried to summarize the current evidence on non-surgical treatment trying to suggest a practical approach to the management of chronic pancreatitis. RESULTS: Besides the unclear pathophysiological mechanism and a poorly unknown epidemiology, chronic pancreatitis is a complex syndrome that displays different possible challenges for physicians. Despite being traditionally considered as a benign disease, chronic pancreatitis encompasses 10-year mortality rates which are superior to the ones reported for some of the most common cancers. CONCLUSIONS: Chronic pancreatitis encompasses the management of multiple and complex medical co-morbidities that needs to be understood and addressed in a multidisciplinary specialist context.


Subject(s)
Conservative Treatment/methods , Pancreatitis, Chronic/therapy , Comorbidity , Humans , Pancreatitis, Chronic/complications , Pancreatitis, Chronic/epidemiology , Pancreatitis, Chronic/mortality , Patient Care Team
2.
J Intern Med ; 283(5): 446-460, 2018 05.
Article in English | MEDLINE | ID: mdl-29474746

ABSTRACT

Senior people constitute the fastest growing segment of the population. The elderly are at risk for malnutrition, thought to be caused by reduced food intake or involution of the physiological capacity of the GI tract. Age-related changes are well known in other secretory organs such as liver, kidney and intestine. The pancreas, representing a metabolically active organ with uptake and breakdown of essential nutritional components, changes its morphology and function with age. During childhood, the volume of the pancreas increases, reaching a plateau between 20 and 60 years, and declines thereafter. This decline involves the pancreatic parenchyma and is associated with decreased perfusion, fibrosis and atrophy. As a consequence of these changes, pancreatic exocrine function is impaired in healthy older individuals without any gastrointestinal disease. Five per cent of people older than 70 years and ten per cent older than 80 years have pancreatic exocrine insufficiency (PEI) with a faecal elastase-1 below 200 µg g-1 stool, and 5% have severe PEI with faecal elastase-1 below 100 µg g-1 stool. This may lead to maldigestion and malnutrition. Patients may have few symptoms, for example steatorrhoea, diarrhoea, abdominal pain and weight loss. Malnutrition consists of deficits of fat-soluble vitamins and is affecting both patients with PEI and the elderly. Secondary consequences may include decreased bone mineral density and results from impaired absorption of fat-soluble vitamin D due to impaired pancreatic exocrine function. The unanswered question is whether this age-related decrease in pancreatic function warrants therapy. Therapeutic intervention, which may consist of supplementation of pancreatic enzymes and/or vitamins in aged individuals with proven exocrine pancreas insufficiency, could contribute to healthy ageing.


Subject(s)
Aging/physiology , Pancreas/physiopathology , Bone Density/physiology , Exocrine Pancreatic Insufficiency/physiopathology , Fibrosis , Humans , Malnutrition/etiology , Osteoporosis/etiology , Pancreas/pathology , Pancreatic Function Tests
3.
Hum Exp Toxicol ; 26(12): 975-8, 2007 Dec.
Article in English | MEDLINE | ID: mdl-18375643

ABSTRACT

1-Propanol and 2-propanol are isomers of an alcohol with three carbons. They are colorless liquids with a sweet odor. 1-Propanol is metabolized by alcohol dehydrogenase to propionic acid and presents with metabolic acidosis and elevated anion gap, whereas 2-propanol is metabolized by alcohol dehydrogenase to acetone and presents with rapidly developing (within 3-4 h after exposure) ketosis and ketonuria but without metabolic acidosis. We report a patient who simultaneously ingested a lethal dose of 1-propanol and 2-propanol as a hand disinfectant in hospital. The patient lost consciousness and stopped breathing within half an hour after ingestion. He was intubated and artificially ventilated. Initial laboratory results showed mixed acidosis with elevated anion gap, but ketonuria appeared only 12 h after admission and 6 h following the regaining of consciousness. Therefore, laboratory results in simultaneous poisoning with two isomers of alcohol are not just a sum of laboratory results obtained in isolated poisoning with each isomer because they influence each other's metabolism: 1-propanol retards the metabolism of 2-propanol to acetone. In conclusion, 1-propanol and 2-propanol poisoning presents early with mixed acidosis and elevated anion gap and only later with ketonuria.


Subject(s)
1-Propanol/poisoning , 2-Propanol/poisoning , Acidosis, Respiratory/chemically induced , Solvents/poisoning , 1-Propanol/pharmacokinetics , 2-Propanol/pharmacokinetics , Acid-Base Equilibrium , Acidosis, Respiratory/therapy , Adult , Amylases/blood , Animals , Drug Synergism , Humans , Ketone Bodies/urine , Male , Rats , Solvents/pharmacokinetics , Suicide, Attempted , Treatment Outcome
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