[The therapeutic effect of somofilin in bronchial asthma patients]. / Lecheben efekt na somofilin pri bolni ot bronkhialna astma.

The sustained release theophylline drug Somophylline in capsules was applied in 21 asthmatic patients (12 women and 9 men), mean age 44.5 years in the course of 14 days in hospital conditions. The dose of the drug was 9-10 mg/kg body mass (24 h given in two equal doses in 12 h intervals). The effect was favourable in 17 patients (80.95%), weak--in 2 patients (9.52%) and no effect in 2 patients (9.52%). Somophylline is very well tolerated. The blood level remains in the therapeutic ranges during the treatment (about 10 micrograms/ml).

[The use of the preparation defedrin in the therapy of bronchial asthma patients]. / Prilozhenie na preparata defedrin v terapiiata na bolni ot bronkhialna astma.

The therapeutic efficacy of the Soviet drug Dephedrin was tried in patients with mild and moderate form of bronchial asthma. The drug was administered in a dose of 0.03 g 3 times daily for a period of 15 days. Out of 10 patients with mild form of bronchial asthma in patients the effect was very good, in 5 patients it was good and in patient it was poor. Out of 10 patients with moderate form of bronchial asthma in 3 patients the effect was very good, in 3 patients it was good and in 4 patients--poor. The ventilation indices improved but without reacting statistical significance. The conclusion is that Dephedrin is suitable for the mild form of bronchial asthma.

[The use of autogenic training in the combined therapy of bronchial asthma patients]. / Prilozhenie na avtogenen trening v kompleksnata terapiia na bolni ot bronkhialna astma.

Since 1976 in the Allergologic Clinic autogenous training is applied in asthmatic patients as group therapy combined with respiratory exercises. In 10 asthmatic patients in the conditions of an acute experiment the forced vital capacity, forced expiratory flow for I s and maximum mean expiratory flow were followed up after autogenous training. An improvement of the ventilation indices was found. The autogenous training is a suitable nonmedicamentous method as a part of the total rehabilitation therapy in asthmatic patients.

[An analysis of the atrovent bronchodilator tests in bronchial asthma patients]. / Analiz na bronkhodilatatorniia test s atrovent pri bolni ot bronkhialna astma.

The aim of the study is to find out the optimum time for reading of the rapid bronchodilation inhalatory test with atrovent in asthmatic patients. The changes of the forced vital capacity, the forced expiratory flow for I s and the maximum expiratory flow were followed up in 21 asthmatic patients 15 min after atrovent inhalation and in 10 patients--20 and 30 min after the inhalation. The results showed a minimum bronchodilation response after 15 min which does not give information about the reversibility of the bronchial obstruction in bronchial asthma. A well-expressed bronchodilation, statistically significant, was found 30 min after the inhalation of atrovent.

[The possible effect of a ketotifen preparation on beta-receptor blockade]. / Prouchvane na vuzmozhniia efekt na preparata ketotifen vurkhu beta-retseptornata blokada.

Parallel clinico-pharmacological studies were carried out of ketotifen action in patients with atopic bronchial asthma and in an experimental model of beta-adrenergic blockade in guinea pigs. The results revealed that ketotifen acts on the beta-adrenergic blockade in the patients with atopic bronchial asthma and in the experimental model in guinea pigs. The ketotifen action on beta-adrenergic blockade resembles that of glucocorticosteroids in efficiency.

[Diagnostic value of various tests frequently used in bronchial asthma]. / Diagnosticana stoinost na niakoi chesto prilagani testove pri bronkhialna astma.

The purpose of the study is to find out a correlation between the inhalation++ broncho-provocative tests and the skin allergic tests as well as a correlation between the inhalation broncho-provocative tests and the level of total and specific immunoglobulins class E. 41 patients with bronchial asthma were examined to whom 52 inhalation broncho-provocative tests with atopic allergens were performed and a comparison with the skin allergic tests with the same allergens was made. The level of the specific immunoglobulins E, reacting as antibodies towards 42 atopic allergens, was examined and the results were compared with those of the inhalation broncho-provocative tests with the same allergens. A moderate correlation between the inhalation broncho-provocative tests and the skin allergic tests and a significant correlation between the inhalation broncho-provocative tests and the specific antibodies level were found.

[The importance of determining the cough reflex threshold in the diagnosis and treatment of respiratory tract diseases]. / Znachenie na opredelianeto na praga na kashlichniia refleks za diagnozata i lechenieto na zaboliavaniiata na dikhatelnite putishta.

The cough reflex was studied in 91 patients classified into two groups: 54 patients with somatic pulmonary disease and marked bronchial hyperreactivity and 37 patients without bronchial hyperreactivity, some of the threatened with bronchial asthma, others with neurotic functional disorders only. The study shows that the stimulated cough reflex could be objectified in the patients, in the patients threatened with bronchial asthma and in some patients with functional disorders linked with neurosis.

[Specific bronchial hyperreactivity and serum IgE antibodies in patients with bronchial asthma and household sensitization]. / Spetsifichna bronkhialna khiperreaktivnost i serumni IgE antitela pri bolni ot bronkhialna astma s bitova senzibilizatsiia.

The task of the study is the parallel examination of the specific bronchial hyperreactivity toward the allergen domestic dust and the level of the specific antibodies of the class IgE. 31 patients with a light form of atopic bronchial asthma and supposed domestic sensibilization were examined. The results showed that the patients with proved domestic sensibilization had high level of specific antibodies of the class IgE toward domestic allergens and positive inhalational bronchial provocative tests with the allergen domestic dust.

[The blood histamine level of patients with bronchial asthma and their skin vascular reaction to histamine]. / Nivo na khistamina v kruvata na bolni ot bronkhialna astma i kozhnosudova reaktivnost kum khistamin.

The relation between the pathochemical phase and the histaminergic reactivity of the effector structures in asthmatic patients was studied. In 124 asthmatic patients classified into two groups the skin vascular reaction to histamine by mediaphoresis and the histamine blood level by two different methods for each group (spectrophotometric and spectrofluorometric) were examined. A linear relation was established between the histamine blood level and the histamine skin vascular reaction.

[Use of the cholinolytic preparation Atrovent in high doses at short intervals in patients with chronic bronchial obstruction]. / Prilozhenie na kholinolitichniia preparat atrovent vuv visoki dozi prez kratki intervali pri bolni s khronichna bronkhialna obstruktsiia.

The bronchodilating efficacy of two doses of Atrovent are studied: the first dose is of 60 mg applied by inhaling once only; the second dose is of 240 mg applied also by inhaling but in divided 4 single doses of 60 mg taken at one hour intervals. 14 asthmatic patients were examined--7 patients with atopic bronchial asthma and 7 patients with non-atopic form of the disease. To all patients the 240 mg dose of Atrovent was given. To 10 of the patients the single 60 mg dose of Atrovent was given at the same conditions but in another day. The larger dose exerts a better and more prolonged bronchodilating action. An optimal dose of 180 mg of Atrovent given by inhalation in divided doses of 60 mg at one hour intervals is recommended. The last 60 mg Atrovent of the 240 mg dose used in the experiment do not improve the immediate bronchodilation which is probably due to a blockade of the receptors by the drug.

[Skin vascular and bronchoreceptor reactivity study of bronchial asthma]. / Izsledvane na kozhnovaskularnata i na bronkhoretseptornata reaktivnost pri bolni ot bronkhialna astma.

The skin-vascular reactivity (SVR) to histamine and adrenaline was studied in 165 patients with bronchial asthma--87 with atopic, 38 with infectious-allergic and 40--with mixed. It was established that in patients with a light course of the disease, the hyperadrenergic SVP and normohistaminergic SVR predominated, whereas in patients with a grave course of the bronchial asthma--mainly hypoadrenergic and hyperhistaminergic SVR was found. The bronchoreceptive reactivity in some of the patients revealed an increased tolerance, to acetylcholine in the patients with hyperadrenergic SVR.