[Familial spinal muscular atrophy of the Kugelberg-Welander type]. / Semeinaia spinal'naia myshechnaia atrofiia tipa Kugel'berga-Velander.

The patients was a 16-year old girl with the spinal muscular atrophy. Clinical laboratory and genetic investigations were performed. A close relative of the proband suffering from the same ailment was found in analysing the genealogic tree. Enzymatic study (creatine phosphokinase, lactic dehydrogenase) of the proband and her parents proved the autosome-recessive type of inheriting the disorder.

[Experimental substantiation of the maximum permissible concentration of Reglone in the air of a work environment]. / Eksperimentalno obosnovavane no predelno dopustimata kontsentratsiia na reglona vuv vuzdukha na rabotnata sreda.

Reglon (20 per cent dikwad dibromide) is an extensively used herbioide and desiccant. During acute and chronic inhalatory experiments on white rats, using 4--hour exposure to water aerosols, determination is made of the acute LC50 -- 83 mg/m3, of the acute threshold concentration - 9.9 mg/m3 acute substance, as well as of the chronic threshold concentration - 0.32 mg/m3. In all instances the clinical picture of intoxication is characterized by pulmonary lesion, and partial involvement of liver and kidneys. The computed zones of acute and chronic inhalatory toxicity warrant the assumption that no sequelae dueto herbicide cumulation in the organism should be expected. At safety coefficient 3, the authors propose 0.1 mg/m3 dikwad dibromide as a temporary limit of the maximum allowable concentration of reglon in the working environment air.

[Changes in the gonads and reproductive capacity of white rats after oral maneb poisoning]. / Promeni v gonadite i v sposobnostta za reproduktsiia na beli plukhove sled oralna intoksikatsiia s maneb.

Changes in the gonads and reproduction capacity of white rats following oral intoxication with maneb are studied. The preparation at doses 1/10, 1/50, 1/100 and 1/5000 LD50 is administered to the starting generation of white rats twice weekly. Changes in the gonads--biochemical, histological, histoenzymatic and electron microscopic--are established, as well as a capacity for reproduction of the starting I and II offspring. The results show a clearcut gonadotropic effect of the preparation, manifested by morphological changes in the starting generation, and by changes in fertility, gestation, survival and lactation of the starting I and II offspring.