ABSTRACT
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a class of medications utilized for the treatment of diabetes mellitus by mechanisms promoting incretin release and insulin production. Although poorly understood, cases of acute pancreatitis have been observed in patients taking GLP-1 RAs. Sodium-glucose co-transporter-2 inhibitors (SGLT-2is) are another class of diabetic medications inhibiting renal glucose reabsorption which have been associated with rare cases of euglycemic ketoacidosis. Acute pancreatitis itself has been an observable cause of diabetic ketoacidosis, although typically in a hyperglycemia state. In this case report, we present a patient on SGLT-2is and GLP-1 RAs who developed acute pancreatitis, which may have precipitated euglycemic diabetic ketoacidosis (eu-DKA).
ABSTRACT
Spontaneous pneumothorax can be a rare complication of thoracic radiation therapy with severe consequences. Most of the cases in the medical literature have been described in lymphoma patients receiving radiation therapy. Spontaneous pneumothoraces are divided into two types which consist of primary and secondary. Primary occurs in absence of any known lung condition, while secondary has an underlying lung disease. The etiology of primary spontaneous pneumothorax has not yet been determined but risk factors such as smoking, family history, and male gender have been described unlike that of secondary which is associated with chronic obstructive pulmonary disease (COPD) and other lung conditions. In this report, we discuss the association with radiation therapy and pneumothorax. The pathogenesis of this complication has not fully been elucidated although different mechanisms have been proposed. In this case report, we discuss the findings and management of a female patient treated for angiosarcoma from the scalp with metastasis to the lung that was complicated by pneumothorax.
