ABSTRACT
Left ventricular diastolic dysfunction in patients with diabetes is formed in the absence of atherosclerotic changes as a consequence of diabetic cardiac autonomic neuropathy in the early stages of diabetes. Progression of autonomic cardiac neuropathy in cardio-vascular type is associated with the violation of energy supply of cells, protein synthesis, electrolyte exchange, the exchange of trace elements, oxidation reduction processes, oxygen-transport function of blood, so that metabolic therapy is carried out to optimize the processes of formation and energy costs. The drug cocarnit activates processes of aerobic oxidation of glucose, as well as providing regulatory influence on the oxidation of fatty acids. Applying of cocarnit in complex therapy in patients with diabetic cardiac autonomic neuropathy found improvement of left ventricular diastolic function, and positive dynamics in the efferent activity balance of the sympathetic and parasympathetic control of heart rate variability, which provides the regression of clinical symptoms.
Subject(s)
Cardiomyopathies/drug therapy , Cardiotonic Agents/therapeutic use , Diabetes Mellitus, Type 2/drug therapy , Diabetic Neuropathies/drug therapy , Ventricular Dysfunction, Left/drug therapy , Adenosine Triphosphate/pharmacology , Adenosine Triphosphate/therapeutic use , Adolescent , Adult , Autonomic Nervous System/drug effects , Autonomic Nervous System/metabolism , Cardiomyopathies/complications , Cardiomyopathies/metabolism , Cardiotonic Agents/pharmacology , Diabetes Mellitus, Type 2/complications , Diabetes Mellitus, Type 2/metabolism , Diabetic Neuropathies/complications , Diabetic Neuropathies/metabolism , Drug Combinations , Fatty Acids/metabolism , Female , Glucose/metabolism , Heart/drug effects , Heart Rate/drug effects , Humans , Male , Middle Aged , Niacinamide/pharmacology , Niacinamide/therapeutic use , Oxidation-Reduction , Thiamine Pyrophosphate/pharmacology , Thiamine Pyrophosphate/therapeutic use , Ventricular Dysfunction, Left/complications , Ventricular Dysfunction, Left/metabolism , Ventricular Function, Left/drug effects , Ventricular Function, Left/physiology , Vitamin B 12/pharmacology , Vitamin B 12/therapeutic useABSTRACT
The paper was conducted sonographic study of extracranial atherosclerotic vascular changes in patients with diabetes mellitus, and lipid profile study of the dynamics under the influence of treatment with the inclusion of the drug "Reytoil". Structural changes of the vascular wall correlates with changes of lipid profile in patients with diabetes. Structural assessment of intima-media complex (IMC) can be used as a marker for early diagnosis of vascular remodeling in patients with diabetes, as well as the criterion of efficiency of a treatment. Detection of lipid exchange and evaluation of IMC in the early stages of diabetes mellitus will make it possible pathogenetic approach to providing comprehensive treatment of diabetes with dyslipidemia, including the drug "Reytoil".