ABSTRACT
The article focuses on scientific and practical activity of the Department of Muscle Biochemistry of the Palladin Institute of Biochemistry of NAS of Ukraine in the context of its foundation and development. Main findings and practical achievements in the area of muscle biochemistry are summarized and discussed.
Subject(s)
Academies and Institutes/history , Biochemistry/history , Muscles/metabolism , History, 20th Century , History, 21st Century , Humans , Ukraine , WorkforceSubject(s)
Academies and Institutes/history , Biochemistry/history , Blood Coagulation Disorders, Inherited/diagnosis , Inventions/history , Blood Coagulation Disorders, Inherited/history , Blood Coagulation Factors/history , Blood Coagulation Factors/metabolism , Blood Coagulation Factors/ultrastructure , History, 20th Century , History, 21st Century , Humans , Ukraine , WorkforceABSTRACT
This article continues analysis of scientific achievements of the Institute of Biochemistry in the study of hemostasis system. Two previous articles were focused on the studies of blood coagulation proteins and development of the immune-enzyme test-systems for evaluation of the risk of thrombosis upon various pathologies. This article highlights the research on the blood fibrinolysis system and new approaches to thrombosis treatment, which were developed (and are under development) in the Palladin Institute of Biochemistry of the NAS of Ukraine, in particular, in the Department of Chemistry and Biochemistry of Enzymes headed previously by Dr.Sci.(Biol.) S. O. Kudinov and now by Dr.Sci.(Biol.) T .V. Grinenko, and also in the Department of Protein Structure and Function headed by Dr.Biol.Sci. E. M. Makogonenko. The fundamental knowledge of protein molecule functions and mechanisms of regulation of blood coagulation and fibrinolysis opens up new opportunities to diagnose hemostasis disorders and control the effectiveness of the cardiovascular disease treatment and also contributes to development of new techniques for isolation of new proteins promising therapeutic agents.
Subject(s)
Academies and Institutes/history , Biochemistry/history , Blood Coagulation Disorders/diagnosis , Diagnostic Tests, Routine/history , Inventions/history , Blood Coagulation Disorders/history , Fibrinolysis/physiology , History, 20th Century , History, 21st Century , Humans , Ukraine , WorkforceABSTRACT
The article is devoted to the inventive activity of the Department of Molecular Immunology of the Palladin Institute of Biochemistry of NAS of Ukraine in the context of the history of its inception, development and in the context of scholarly and organizational activities of Sergii Vasyl'ovych Komisarenko. This autumn marks 50th anniversary since young Sergii Komisarenko (now Academician of NAS and NAMS of Ukraine, Dr. Biol. Sci., Professor) has joined the Palladin Institute of Biochemistry, has completed all stages of the academic carrier from PhD student to Head of the Institute. He is the first in Ukraine who started the new branch of research molecular immunology, created a strong scientific school, which earned worldwide acclaim and made significant contribution to finding solutions to current problems in human health sciences. S.V. Komisarenko was among those, who were first in the USSR to use immunoenzyme and flow cytofluometric assays, hybridoma technology for producing monoclonal antibodies and immunochemical assay of proteins, which became the basis for development of highly sensitive and highly specific immunodiagnostic systems, which are of high necessity in medicine, veterinary, development of immunotechnologies, environment monitoring, etc. Under his leadership the Department has made a series of important discoveries and developments including relating to antitumour immunotoxins, effects of low dose radiation on the immune system of Chernobyl liquidators, immunochemical structure of neurotoxin apamine, cytochrom c, fibrinogen and fibrin molecules at different stages of polymerization, diphtheria toxin and its receptor, tuberculosis causing micobacterium, roles of protease-activated receptors (PARs) and nicotinic acetylcholine receptors of lymphocytes, nature of polyreactive immunoglobulins (PRIGs), among other important scientific contributions. S.V. Komisarenko and his colleagues also hold numerous (more than 80) author's certificates and patents in Ukraine and USSR.
Subject(s)
Academies and Institutes/history , Allergy and Immunology/history , Biochemistry/history , Inventions/history , History, 20th Century , History, 21st Century , Humans , Immunoglobulins/analysis , Ukraine , WorkforceABSTRACT
The article is devoted to the inventive activity of the Department of Metabolism Regulation of the Palladin Institute of Biochemistry of NAS of Ukraine in the context of the history of its inception, development and the research activities of its founder, academician of NAS of Ukraine M. F. Guly as well as his students and followers. It briefly tells about practical achievements of M. F. Guly which were as significant, immense and diverse as his scientific accomplishments. The paper analyses in detail the practical results of scientific research of his students and followers aimed to solve practical problems of medicine, food-processing, agriculture, and which are essentially a continuation of the ideas and projects of M. F. Guly.
Subject(s)
Academies and Institutes/history , Biochemistry/history , Inventions/history , History, 20th Century , History, 21st Century , Ukraine , WorkforceSubject(s)
Academies and Institutes/history , Biochemistry/history , History, 20th Century , Humans , Patents as Topic , UkraineSubject(s)
Awards and Prizes , Biochemistry/history , Academies and Institutes , History, 20th Century , History, 21st Century , Humans , UkraineSubject(s)
Academies and Institutes/history , Biochemistry/history , Biopharmaceutics , Biotechnology , Medical Laboratory Science , Biopharmaceutics/history , Biopharmaceutics/methods , Biotechnology/history , Biotechnology/methods , History, 20th Century , History, 21st Century , Medical Laboratory Science/history , Medical Laboratory Science/methods , UkraineSubject(s)
Academies and Institutes/history , Biochemistry/history , History, 20th Century , UkraineSubject(s)
Academies and Institutes/history , Awards and Prizes , Biochemistry/history , History, 20th Century , Humans , UkraineSubject(s)
Academies and Institutes/history , Biochemistry/history , Brain/drug effects , Brain/metabolism , History, 20th Century , Ion Transport/drug effects , Neurons/drug effects , Neurons/metabolism , Psychotic Disorders/drug therapy , Psychotic Disorders/metabolism , Psychotropic Drugs/pharmacology , UkraineABSTRACT
The content of cAMP and cGMP in the composition of the high-molecular complex aminoacyl-tRNA-synthetase from the rat liver has been studied. The ionizing radiation decreases the level of the cyclic nucleotides in the composition of the complex. A problem on interregulation of the cyclic nucleotides and prostaglandins in the complex has been examined.