ABSTRACT
Nonsymmetrical aldehyde derivatives of gossypol, a yellow polyphenolic pigment of cottonseed, were synthesized by reactions with ammonia, aniline, 4-aminoantipyrine, and barbituric acid. Their structures were determined by UV spectrophotometry and IR and (1)H NMR spectroscopy methods. Their acute toxicities in white mice were compared with those of gossypol and the corresponding symmetrical analogues. It was demonstrated that in general, the fewer free aldehyde groups that contained the gossypol derivative, the lower its acute toxicity. Only in the case of a nonsymmetrical gossypol derivative bearing a 4-aminoantipyrine residue did we observe a deviation from the above correlation: its symmetrical counterpart was even more toxic, but still less toxic than gossypol.
Subject(s)
Aldehydes/chemical synthesis , Gossypol/analogs & derivatives , Gossypol/chemical synthesis , Aldehydes/toxicity , Animals , Gossypol/toxicity , Lethal Dose 50 , Mice , Structure-Activity RelationshipABSTRACT
It was established in rabbit experiments that intravenous infusion of 150 BU/kg of the mouse nerve growth factor causes long-term hypocoagulation and simultaneous stimulation of fibrinolysis and anticoagulant activity. The essential role of the nerve growth factor in inducing the release of heparin and histamine into the blood and its contribution to the activation of other components of fibrinolysis and the antithrombine system is shown. This may be very important for the prevention of prethrombotic conditions in the future.
