ABSTRACT
This paper describes the use of an interactive simulation system (SONCHES) as a model and databank system. The basic model is a physiologically based toxicokinetic model (partition coefficient concept). This model takes circulation times into consideration and includes a metabolic subsystem with spot urine output. Data libraries related to the physiology of mammals, chemical substances, the external environment (exposure, physical activity, skin uptake, water intake) and real experiments allow various simulation experiments (scenarios). Scenario service and result post processing can be used to compare real experiment and simulated data (data-gathering and interpretation).
Subject(s)
Computer Simulation , Databases, Factual , Environmental Monitoring/methods , Environmental Pollutants/toxicity , Models, Theoretical , Environmental Pollutants/analysis , HumansSubject(s)
Air Pollutants, Occupational/toxicity , Dimethylformamide/toxicity , Occupational Diseases/chemically induced , Adult , Chromosome Aberrations , Clinical Enzyme Tests , Dimethylamines/toxicity , Female , Formamides/toxicity , Germany, East , Humans , Male , Middle Aged , Occupational Diseases/epidemiologySubject(s)
Child Development , Cleft Lip/psychology , Cleft Palate/psychology , Adult , Child , Female , Humans , Intelligence , Male , Parent-Child Relations , Social BehaviorSubject(s)
Heart Rate , Monitoring, Physiologic , Telemetry/methods , Computers , Humans , Occupational Medicine , WorkSubject(s)
Aminopeptidases/urine , Occupational Diseases/diagnosis , Humans , Kidney/physiopathologyABSTRACT
The flavonoid constituents of carrot leaves (Daucus carota L. ssp. sativa) were separated by means of cellulose column chromatography, and the following compounds were obtained crystalline and identified by usual procedures: luteolin 7-beta-D-glucoside as the main flavon, luteolin 4'-beta-D-glucoside, luteolin 7-beta-D-glucuronide, apigenin 7-beta-D-glucoside, apigenin 7-rutinoside, chrysoeriol 7-beta-D-glucoside. Luteolin 7-rutinoside also was identified, but could not be obtained crystalline.
