[Chronic disseminated histiocytosis X. A case with unusual liver involvement]. / Chronische disseminierte Histiocytosis X. Ein Fall mit ungewöhnlicher Leberbeteiligung.

A chronic disseminated histiocytosis X of a 37-year-old patient is reported on. Besides the classical Hand-Schüller-Christian-trias the involvement of central parts of the liver with jaundice and cholangitis was predominant.

[Studies of dialysis patients using the 14C aminophenazone breath test]. / Untersuchungen von Dialysepatienten mit dem 14C-Aminophenazon-Atemtest.

In 12 endstage kidney disease patients (8 liver healthy and 4 with liver diseases) the activities of cytochrome P450-dependentmixed functional oxidases system (MFO) of the liver were studied by using the 14C-aminophenazon breath test before and after dialysis. We were interested in the influence of uremia and dialysis treatment on MFO-activity. Our results show that uremia seems to have a pressing influence on MFO-activity. The activity was only significantly increased after dialysis in the group of patients without liver disease. We observed that the MFO-activity was reduced in patients with liver diseases. This is a restriction of the liver metabolic demethylation capacity. It is unclear if the 14C-aminophenazone breath test in dialysis patients is qualified to estimate metabolic capacity of the liver. Differentiation between the influence of uremia and of the liver disease on the alteration of MFO-activity cannot be made.

[Value of systemic streptokinase therapy in thromboembolism diseases]. / Zum Stellenwert der systemischen Streptokinasetherapie bei thromboembolischen Erkrankungen.

Among 27,756 cases with stationary treatment 1,532 patients were found in whom a systemic fibrinolysis therapy was taken into consideration. Under strict attention to indications and contraindications 173 patients were treated with streptokinase. The rate of treatment failures in peripheral arterial obstructions was 46%, in venous thromboses 29%. The lethality of pulmonary embolisms could be decreased significantly, in acute myocardial infarction however, it could not be reduced. In 10% of the cases we observed severe therapeutic complications. The systemic streptokinase therapy is therefore a certainly effective, but also high-risk method of treatment, which must be performed by an experienced physician.

[Vascular anomalies of the gastrointestinal tract--an unusual case of multiple intra-abdominal hemangiomas]. / Gefässanomalien des Gastrointestinaltraktes--ein ungewöhnlicher Fall multipler intraabdomineller Hämangiome.

A case of multiple abdominal haemangiomas (mesentery, intestine, liver) in a 19 year-old patient is described. The anomalies, at first incidentally found during appendectomy, were confirmed by angiographies and vascular surgery. Ascites and bleeding esophageal varices developed in further course. A short review of literature and classifications is given.

[Experience using a transcutaneous pO2 measuring technic in the early postoperative phase following thoracotomy]. / Erfahrungen mit der transkutanen pO2-Messtechnik in der frühen postoperativen Phase nach Thorakotomien.

Early postoperative transcutaneous pO2 measurements as well as complex blood gas analyses were done in patients undergoing chest surgery. The non-invasive transcutaneous measurement-technique increases the safety of the postoperative treatment and permits early recognition of respiratory insufficiency. Controls of arterial pO2 are required only in greater intervals.

[Complications of retrograde arterial catheterizations in infants and children (author's transl)]. / Komplikationen retrograder arterieller Katheteruntersuchungen bei Säuglingen und Kindern.

550 retrograde arterial catheterizations, performed between 1974 and 1980, including 50 infants below the age of one year, 120 children between one and 5 years of age and 380 schoolchildren, were reviewed with respect to the rate of complications. Within this period the portion of open arteriotomies decreased from 41% during 1974-1977 to 7% during 1978-1980. Only 130 patients had systemic heparinization during the catheterization procedure, without preponderance of any age group. Complications occurred in 10% of the patients, 4% being major complications necessitating mostly thrombectomia or thrombolysis. The rate of major complications decreased from 6% during the first period (1974-77) to 3% during the second period (1979-80), which can partly be attributed to the decrease of open arteriotomies within the entire period. According to our results the open arteriotomy of the A. femoralis should be avoided as far as possible. The rate of arterial obstructions was highest in infancy, where it amounted to 14%, and did not change considerably between the first and second period of time in this age group. In schoolchildren, however, the rate of arterial obstruction diminished from 7% during the first period to 0.5% during the second period. Considering the entire period, systemic heparinization did not appear to influence significant the rate of complications. During the last 3 years, however, arterial obstruction was observed in none of 74 patients having undergone systemic heparinization, but in 8 of 228 patients without this measure, 7 of them being infants and children below the age of 6 years. We therefore conclude that systemic heparinization should be performed in infants and small children during retrograde catheterization.