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1.
Transplant Proc ; 50(7): 2110-2112, 2018 Sep.
Article in English | MEDLINE | ID: mdl-30177119

ABSTRACT

BACKGROUND: Transplant rejection is one of the major problems after heart transplantation (HTx). The aim of the study was to find possible links between chosen single-nucleotide polymorphisms (SNPs) of Toll-like receptor 4 (TLR4) and heart transplant rejection. MATERIAL AND METHODS: Blood samples were taken from 24 patients subjected to HTx between 2010 and 2016 at the Clinic of Cardiac Surgery and Transplantation and under the control of I Clinic of Cardiology. All the patients were permanently controlled and had therapeutic levels of immunosuppressants in their blood. Their DNA was isolated and analyzed using the high-resolution melting method according to the Toll-like receptor 4 SNPs rs10983755 A/G, rs4986791 C/T, rs4986790 A/G, rs10759932 C/T, rs1927911 C/T, rs11536889 C/G, and rs12377632 C/T. The analysis of the clinical data of biopsies according to International Society for Heart and Lung Transplantation classification was derived from the patients' medical history, divided into two groups: 0-1b and 2-4. A statistical analysis was then performed. RESULTS: The results obtained showed no association between analyzed SNPs and rejection. For rs10983755 A/G, P = .85; rs4986791 C/T, rs4986790 A/G, and rs1927911 C/T had P = .35; and rs10759932 C/T, rs11536889 C/G, and rs12377632 C/T had P = 1. CONCLUSIONS: No association between the SNPs rs10983755 A/G, rs4986791 C/T, rs4986790 A/G, rs10759932 C/T, rs1927911 C/T, rs11536889 C/G, and rs12377632 C/T and heart transplant rejection was found, but further investigation is suggested for TLR4 SNPs with P < .5.


Subject(s)
Genetic Predisposition to Disease/genetics , Graft Rejection/genetics , Heart Transplantation/adverse effects , Polymorphism, Single Nucleotide , Toll-Like Receptor 4/genetics , Adult , Aged , Female , Humans , Male , Middle Aged
2.
Kardiol Pol ; 38(2): 98-101, 1993 Feb.
Article in Polish | MEDLINE | ID: mdl-8230988

ABSTRACT

Transient elevation of serum enzyme level and abnormalities of repolarization following electrical cardioversion (EC) are usually observed. We aimed to alleviate these alterations by pretreatment with magnesium sulfate (MgSO4). The study group consists of 100 patients (aged 19-65 years) who had EC (300 W/sec) for chronic atrial fibrillation after mitral and/or aortic valve surgery. They were randomly divided into two sub groups: 50 patients in whom MgSO4 was administered intravenously (dose 100 m/kg b.w.) and 50 control subjects. Total serum magnesium level and CKMB level were recorded before and 8 hours after EC. Recovery to sinus rhythm, QTc interval, segment shifts were recorded immediately before and after EC. Results (mean +/- SE): [table: see text] Our results suggest that MgSO4 administered before EC has a significant cardioprotective effect and reduces abnormalities of repolarization.


Subject(s)
Atrial Fibrillation/therapy , Electric Countershock , Heart/drug effects , Magnesium Sulfate/therapeutic use , Postoperative Complications/therapy , Premedication , Adult , Aged , Atrial Fibrillation/blood , Atrial Fibrillation/etiology , Humans , Middle Aged , Treatment Outcome
3.
Pol Arch Med Wewn ; 88(6): 458-61, 1992 Dec.
Article in Polish | MEDLINE | ID: mdl-1300568

ABSTRACT

The giant size thrombus like a swallow's nest in the left cardiac ventricle in the patient with a history of anterior infarction was reported. In the autopsy a significant narrowing of the left coronary artery and two critical narrowings of the anterior interventricular artery were revealed. The relation between the localization of the pathological changes in the coronary arteries and the thrombi occurring during cardiac infarction was discussed.


Subject(s)
Heart Diseases/pathology , Myocardial Infarction/complications , Thrombosis/pathology , Aged , Coronary Vessels/pathology , Heart Diseases/etiology , Humans , Male , Thrombosis/etiology
4.
Kardiol Pol ; 37(8): 74-8, 1992 Aug.
Article in Polish | MEDLINE | ID: mdl-1434328

ABSTRACT

265 patients (168 women, 97 men) after cardiac surgery (mitral valve replacement--74 pts, mitral commissurotomy--158 pts, aortic valve replacement--6 pts, replacement of both valves--16 pts, closure of ASD--11 pts) were randomized after successful electro-conversion of atrial fibrillation to quinidine (63 pts), verapamil (56 pts), amiodarone (50 pts), digoxin (56 pts) or control group (40 pts). The groups were comparable regarding age, sex and mitral valve disease distribution, heart volume, echocardiographic left atrium size and time from cardiac surgery to electro-conversion. After one year sinus rhythm was still present in 43% receiving quinidine, 43% receiving verapamil, 40% receiving amiodarone, 22% receiving digoxin, 20% in the untreated group, and after two years in 14%, 11%, 20%, 0% and 0%--respectively. The treatment was discontinued because of side effects in 13% of pts in the quinidine group, 8% of pts in the amiodarone group and 4% of pts in the verapamil group. It is concluded that quinidine, amiodarone and verapamil compared with control group are significantly (p less than 0.05--after one year) more effective in preventing late relapses of atrial fibrillation. Digoxin is ineffective in preventing recurrence of the arrhythmia. There are no significant differences between quinidine, verapamil and amiodarone regarding its prophylactic efficacy.


Subject(s)
Anti-Arrhythmia Agents/administration & dosage , Aortic Valve Stenosis/surgery , Atrial Fibrillation/prevention & control , Electric Countershock , Heart Valve Prosthesis , Mitral Valve Stenosis/surgery , Postoperative Complications/prevention & control , Aortic Valve Stenosis/complications , Atrial Fibrillation/etiology , Atrial Fibrillation/therapy , Female , Humans , Male , Mitral Valve Stenosis/complications , Postoperative Complications/etiology , Postoperative Complications/therapy , Recurrence
5.
Kardiol Pol ; 34(6): 367-70, 1991.
Article in Polish | MEDLINE | ID: mdl-1942748

ABSTRACT

We present a case history of 29-year old female with infective endocarditis, who was admitted 15 months after neurosurgical treatment of disruption of cerebral aneurysm. The diagnosis of organic heart disease had been established in her childhood. 6 months after discharge from neurosurgery she developed marked dyspnoea on exertion and became febrile (up to 39.0 C). The presumptive diagnosis of infective endocarditis was established 6 months later, when she developed the symptoms and signs of severe anaemia with ESR 170 mm/hr although blood cultures were negative. The patient underwent treatment with Penicillin and Debecillin. On admission to our Institute echocardiography showed a very large, mobile vegetation in the left ventricle, connected to the anterior leaflet of mitral valve. Decision of mitral valve replacement was made, but rupture of the next cerebral aneurysm was the reason of unexpected, sudden death of the patient. The postmortem examination revealed 7 x 4 cm large vegetation, with the mass of 7.0 g. Histologically the vegetation consisted of mass of fibrin strands, platelets and blood cell with inflammatory cells. On its base the signs of the process of organization were marked. This vegetation was the largest one that we found in literature on this subject.


Subject(s)
Endocarditis, Bacterial/pathology , Mitral Valve/pathology , Adult , Echocardiography , Endocarditis, Bacterial/diagnostic imaging , Female , Humans , Mitral Valve/diagnostic imaging
6.
Kardiol Pol ; 35(9): 170-3, 1991.
Article in Polish | MEDLINE | ID: mdl-1753562

ABSTRACT

In 82 patients after mitral valve surgery (59--commissurotomy, 23--valve replacement--Björk-Shiley or St. Jude prosthetic valve), 2-D and Doppler echocardiography were performed one day before electrical cardioversion. Regular sinus rhythm was maintained to 180 days in 28 patients (34%), over 180 days in 54 patients (66%). The statistical differences (p less than 0.05) between the following echocardiography parameters of these two groups were determined: parasternal long axis view: aortic, atrial, right and left ventricular dimensions (not significant--NS); apical four-chamber view: left and right atrial, left and right ventricular areas--NS; apical two-chamber view: left atrial area--p less than 0.05; pulmonary valve: peak flow velocity--NS, acceleration time--NS; mitral valve: effective area--p less than 0.05, pressure half-time--p less than 0.05, mean gradient--NS, mean flow--NS, E-wave max. flow velocity--NS. These data suggest, that left atrial area less than 30 cm2 derived from two-chamber view and Doppler effective mitral area more or equal 2, 10 cm2 may be important and good predictors of long-term results of cardioversion in patients after mitral valve surgery.


Subject(s)
Atrial Fibrillation/therapy , Electric Countershock , Heart Valve Prosthesis/adverse effects , Mitral Valve Insufficiency/surgery , Mitral Valve/surgery , Postoperative Complications/therapy , Adult , Atrial Fibrillation/etiology , Atrial Fibrillation/physiopathology , Echocardiography/methods , Echocardiography, Doppler , Heart Atria/diagnostic imaging , Heart Atria/physiopathology , Humans , Middle Aged , Mitral Valve/diagnostic imaging , Mitral Valve/physiopathology , Postoperative Complications/etiology , Postoperative Complications/physiopathology , Prognosis , Time Factors
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