ABSTRACT
OBJECTIVE: To determine whether the concentration of hCG in cervical fluid can predict miscarriage during early pregnancy. DESIGN: Prospective clinical study. SETTING: University hospital. PATIENT(S): Ninety-nine women with singleton pregnancies, 17 of whom suffered a miscarriage. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Miscarriage and the cervical fluid/serum hCG concentration ratio. RESULT(S): With a cutoff value of 1.0, the sensitivity, specificity, and positive and negative predictive values of the cervical fluid/serum hCG concentration ratio for predicting miscarriage were 88.2%, 94.9%, 83.3%, and 96.6%, respectively. CONCLUSION(S): The cervical fluid/serum hCG concentration ratio might be a useful predictor of miscarriage during early pregnancy.
