ABSTRACT
An 18-year-old male was evaluated for recurrent attacks of right abdominal pain and intermittent jaundice caused by hydatid cysts of the liver. The case illustrates the value of dynamic functional information provided by Tc-99m-HIDA imaging over noninvasive modalities that demonstrate structural changes, such as ultrasound, computed tomography, and tin colloid liver imaging.
Subject(s)
Cholestasis, Intrahepatic/etiology , Echinococcosis, Hepatic/complications , Technetium Compounds , Tin Compounds , Adolescent , Cholangiopancreatography, Endoscopic Retrograde , Cholestasis, Intrahepatic/diagnosis , Echinococcosis, Hepatic/diagnosis , Humans , Imino Acids , Male , Organometallic Compounds , Technetium , Technetium Tc 99m Lidofenin , Tin , Tomography, X-Ray Computed , UltrasonographyABSTRACT
Technetium-99m mercaptoacetyltriglycine (99Tcm-MAG3) was evaluated for the detection and localization of the site of gastrointestinal bleeding in a sheep model. Radioactivity was detected in both the stomach and lower abdomen. However, 99Tcm-MAG3 is partially excreted by the liver and in the bile. The radioactivity in the bile moved to the small bowel. This movement of radioactivity in the lower abdomen can lead to a misinterpretation of the site of bleeding. Hence, 99Tcm-MAG3 may not be an effective radiopharmaceutical for the localization of the site of bleeding in the gastrointestinal tract, particularly the lower abdomen.
Subject(s)
Gastrointestinal Hemorrhage/diagnostic imaging , Oligopeptides , Organometallic Compounds , Technetium , Animals , Disease Models, Animal , Drug Evaluation , Radionuclide Imaging , Sheep , Technetium Tc 99m Mertiatide , Time FactorsABSTRACT
Acute pancreatitis is a serious surgical problem with a high incidence of mortality. Both ultrasound and X-ray CT have problems in identifying the extent and severity of the disease and the response to therapy. 67Ga-citrate has been used in 21 patients with clinically diagnosed acute pancreatitis: 9 patients had X-ray CT and 15 had US examination. Gallium scans were more sensitive than X-ray CT and US in detecting the extent and severity of acute pancreatitis. In addition, gallium was helpful to monitor the response to therapy when the scan was repeated at various intervals in three patients. A subtraction technique using 99mTc-tin colloid and 67Ga-citrate was helpful to mask the liver uptake of gallium and clearly identify the extent of acute pancreatitis.
Subject(s)
Gallium Radioisotopes , Pancreatitis/diagnostic imaging , Acute Disease , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Radionuclide ImagingABSTRACT
Four Tc-99 radiopharmaceuticals, Tc-99m sulphur colloid, Tc-99m red blood cells (RBCs), Tc-99m mercaptoacetyltriglycine (MAG3), and Tc-99m DTPA, were studied in an experimental animal model for detection and localization of gastrointestinal (GI) bleeding site in both the upper and lower abdomen. With Tc-99m sulphur colloid and Tc-99m RBCs, it was possible to detect and localize the GI bleeding site in the lower abdomen. With Tc-99m MAG3, it was possible to visualize the bleeding site in both the upper and lower abdomen. However, Tc-99m MAG3 is partially excreted by the liver into the bile, hence it will be difficult to use Tc-99m MAG3 to localize the GI bleeding site in the lower abdomen. With Tc-99m DTPA, it was possible to detect and localize the GI bleeding site simultaneously in both upper and lower abdomen. The overall background radioactivity was reduced considerably by diuresis with frusemide and catheterization of the urinary bladder.
