ABSTRACT
Taraxer-14-en-3beta-ol ( 1) was shown to be the active ingredient in the leaves of Sterculia foetida L. The alcohol 1, its acetate and ketone showed anti-inflammatory activity against TPA induced mouse ear oedema with inhibition ratios of 60.0, 58.57 and 40.57 at 0.5 mg/ear, respectively. The percentage inhibition of inflammation increased with dose for each compound.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Edema/prevention & control , Oleanolic Acid/analogs & derivatives , Oleanolic Acid/pharmacology , Phytotherapy , Plant Extracts/pharmacology , Sterculia , Animals , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Edema/chemically induced , Male , Mice , Oleanolic Acid/administration & dosage , Oleanolic Acid/therapeutic use , Plant Extracts/administration & dosage , Plant Extracts/therapeutic use , Plant LeavesABSTRACT
An alcoholic extract of Sterculia foetida L. leaves was subjected to pharmacological screening using various animal models. The extract caused reduced exploratory activity in mice. Further it potentiated pentobarbitone sleeping time in normal and chronic pentobarbitone-treated mice. It also potentiated barbital sodium-induced hypnosis, indicating central nervous system depressant activity. The extract also exhibited significant antiinflammatory activity in the acute carrageenan-induced rat paw edema and the chronic granuloma pouch models. However, it was devoid of analgesic activity in the tail flick model.
