Acoustic Roughness Measurement of Railway Tracks: Running Surface Detection and Compensation of Lateral Movements for Optical Measurements on a Train.

Rolling noise is a significant contributor to railway noise. Wheel and rail roughness are decisive for the emitted noise level. An optical measurement method installed on a moving train is suitable for closer monitoring of the rail surface condition. A measurement setup based on the chord method requires the sensors to be positioned in a straight line along the direction of measurement and in a stable lateral position. Measurements should always be performed within the shiny and uncorroded running surface, even when there are lateral movements of the train. In this study, concepts for the detection of the running surface and the compensation of lateral movements are investigated in a laboratory setting. The setup consists of a vertical lathe with a ring-shaped workpiece that incorporates an implemented artificial running surface. The detection of the running surface based on laser triangulation sensors and a laser profilometer is investigated. It is shown that the running surface can be detected using a laser profilometer that measures the intensity of the reflected laser light. It is possible to detect the lateral position and the width of the running surface. A linear positioning system is proposed to adjust the lateral position of the sensors based on the running surface detection of the laser profilometer. When the lateral position of the measuring sensor is disturbed by a movement with a wavelength of 18.85 m, the linear positioning system can keep the laser triangulation sensor inside the running surface for 98.44% of the measured data points at a velocity of approximately 7.5 km h-1. The mean positioning error is 1.40 mm. By implementing the proposed system on the train, future studies can be conducted to examine the lateral position of the running surface as a function of the various operational parameters of the train.

Developmental cell death of cortical projection neurons is controlled by a Bcl11a/Bcl6-dependent pathway.

Developmental neuron death plays a pivotal role in refining organization and wiring during neocortex formation. Aberrant regulation of this process results in neurodevelopmental disorders including impaired learning and memory. Underlying molecular pathways are incompletely determined. Loss of Bcl11a in cortical projection neurons induces pronounced cell death in upper-layer cortical projection neurons during postnatal corticogenesis. We use this genetic model to explore genetic mechanisms by which developmental neuron death is controlled. Unexpectedly, we find Bcl6, previously shown to be involved in the transition of cortical neurons from progenitor to postmitotic differentiation state to provide a major checkpoint regulating neuron survival during late cortical development. We show that Bcl11a is a direct transcriptional regulator of Bcl6. Deletion of Bcl6 exerts death of cortical projection neurons. In turn, reintroduction of Bcl6 into Bcl11a mutants prevents induction of cell death in these neurons. Together, our data identify a novel Bcl11a/Bcl6-dependent molecular pathway in regulation of developmental cell death during corticogenesis.