Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 3 de 3
Filter
Add more filters










Database
Language
Publication year range
1.
AJNR Am J Neuroradiol ; 30(6): 1142-8, 2009 Jun.
Article in English | MEDLINE | ID: mdl-19246528

ABSTRACT

BACKGROUND AND PURPOSE: Patients with agenesis of the corpus callosum (AgCC) exhibit cognitive and behavioral impairments that are not replicated by surgical transection of the callosum, suggesting that other anatomic changes may contribute to the observed clinical findings. The purpose of this study was to determine whether the ventral cingulum bundle (VCB) is affected in patients with AgCC by using diffusion tensor imaging (DTI) and volumetry. MATERIALS AND METHODS: Twelve participants with AgCC (8 males and 4 females; mean age, 30 +/- 20) and 12 control subjects matched for age and sex (mean age, 37 +/- 19) underwent MR imaging and DTI at 3T. 3D fiber tracking of the VCB was generated from DTI and the average fractional anisotropy (FA) was computed for the tracked fibers. Additionally, the volume, cross-sectional area, and length of the VCB were measured by manually drawn regions of interest on thin-section coronal T1-weighted images. The Student t test was used to compare these results. RESULTS: Compared with controls, subjects with AgCC demonstrated significantly reduced FA in the right VCB (P = .0098) and reduced volume and cross-sectional areas of both the left and right VCB (P < .001 for all metrics). The length of the VCB was also significantly reduced in the complete AgCC subgroup compared with controls (P = .030 in the right and P = .046 in the left, respectively). CONCLUSIONS: Patients with AgCC have abnormal microstructure and reduced volume of the VCB, suggesting that abnormalities in intrahemispheric white matter tracts may be an important contributor to the clinical syndrome in patients with AgCC.


Subject(s)
Agenesis of Corpus Callosum , Corpus Callosum/pathology , Diffusion Magnetic Resonance Imaging/methods , Imaging, Three-Dimensional/methods , Adult , Female , Humans , Male , Organ Size , Reproducibility of Results , Sensitivity and Specificity
2.
AJNR Am J Neuroradiol ; 30(2): 282-9, 2009 Feb.
Article in English | MEDLINE | ID: mdl-19001538

ABSTRACT

BACKGROUND AND PURPOSE: Little is known about the anatomic connectivity of callosal axons in individuals with partial agenesis of the corpus callosum (pAgCC). We used tractography based on both diffusion tensor imaging (DTI) and high angular resolution diffusion imaging (HARDI) to investigate interhemispheric white matter connectivity in pAgCC. MATERIALS AND METHODS: DTI and HARDI were performed at 3T on 6 individuals with pAgCC and 8 control subjects. For HARDI analysis, a Q-ball reconstruction method capable of visualizing multiple intravoxel fiber orientations was used. In both DTI and HARDI, whole-brain 3D fiber tractography was performed by using deterministic streamline algorithms. Callosal fibers were then segmented to identify separately connections between homologous cortical regions (homotopic fibers) and nonhomologous regions (heterotopic fibers) by using manually drawn regions of interest. RESULTS: In control individuals, we observed densely connected homotopic fibers. However, in individuals with pAgCC, we identified not only homotopic connections but also heterotopic connections in 4 of 6 subjects. Furthermore, the observed homotopic connections in pAgCC did not necessarily correlate with the position or size of the residual callosum. The nature of homotopic and heterotopic connectivity varied considerably among subjects with pAgCC, and HARDI recovered more callosal fibers than DTI. CONCLUSION: Individuals with pAgCC demonstrate a remarkable diversity of callosal connectivity, including a number of heterotopic tracts that are absent in healthy subjects. The patterns of their callosal connections cannot be predicted from the appearance of their callosal fragments on conventional MR imaging. More tracts and more extensive fibers within tracts are recovered with HARDI than with DTI.


Subject(s)
Acrocallosal Syndrome/pathology , Brain Diseases/pathology , Choristoma/pathology , Diffusion Magnetic Resonance Imaging/methods , Neural Pathways/pathology , Adolescent , Adult , Aged , Cerebral Cortex/pathology , Female , Humans , Image Processing, Computer-Assisted , Male , Middle Aged , Models, Neurological , Nerve Fibers, Myelinated/pathology , Young Adult
3.
Neurology ; 65(9): 1496-8, 2005 Nov 08.
Article in English | MEDLINE | ID: mdl-16275846

ABSTRACT

Absence of the corpus callosum is often associated with cognitive deficits, autism, and epilepsy. Using a genomic microarray, the authors analyzed DNA from 25 patients with radiographically confirmed callosal anomalies and identified three patients with de novo copy number changes in chromosome regions 2q37, 6qter, and 8p. Chromosomal deletions and duplications may be a relatively common cause of cerebral malformations.


Subject(s)
Agenesis of Corpus Callosum , DNA/genetics , Genetic Predisposition to Disease/genetics , Mutation/genetics , Nervous System Malformations/genetics , Child , Child, Preschool , Chromosome Deletion , Chromosomes, Human, Pair 2/genetics , Chromosomes, Human, Pair 6/genetics , Chromosomes, Human, Pair 8/genetics , Corpus Callosum/physiopathology , DNA/analysis , DNA Mutational Analysis , Female , Gene Dosage , Gene Duplication , Genetic Testing , Genomic Library , Humans , Male , Nervous System Malformations/complications , Oligonucleotide Array Sequence Analysis , Prospective Studies
SELECTION OF CITATIONS
SEARCH DETAIL
...