ABSTRACT
Sex hormone allergy as a clinical syndrome has been known for almost a century. Due to the diversity of clinical presentation regarding symptoms and disease patterns, the optimal patient care represents an enormous interdisciplinary challenge. Frequently, hypersensitivity reactions affect more than one sex hormone and double positive tests for estrogen and progesterone have been described. Since the menstrual cycle dependent symptoms range from skin afflictions, gynecological problems to non-specific reactions, different pathophysiological mechanisms seem likely. Various desensitization protocols are described as causal treatment options, but are rarely applied in clinical routine. Consequently, major research efforts with a quick translation of therapeutic interventions into clinical practice will be crucial to help affected patients in the future.
Subject(s)
Heart Transplantation/physiology , Postoperative Complications/surgery , Austria/epidemiology , Cause of Death , Disease-Free Survival , Female , Follow-Up Studies , Graft Rejection/epidemiology , Graft Rejection/prevention & control , Heart Transplantation/mortality , Hospitals, University , Humans , Male , Middle Aged , Reoperation , Retrospective Studies , Stroke/mortality , Survival Rate , Ventricular Dysfunction, Right/mortalitySubject(s)
Graft Survival/physiology , Heart Transplantation/physiology , Adolescent , Adult , Age Factors , Austria , Cause of Death , Child , Child, Preschool , Follow-Up Studies , Graft Rejection/epidemiology , Heart Transplantation/mortality , Hospitals, University , Humans , Retrospective Studies , Survival Rate , Time Factors , Tissue and Organ Procurement/statistics & numerical data , Treatment OutcomeABSTRACT
PURPOSE: To report the effect of a single dose of oxytocin on ejaculation time and seminal parameters. METHODS: The prospective randomized clinical study was performed at a private assisted reproduction technology center and included 103 consecutive healthy men (semen donors or husbands of IVF patients). Oxytocin (16 IU) were administered intranasally to 49 subjects, randomly assigned to the study group just before masturbation to ejaculation. The time needed for ejaculation as well as the semen parameters was recorded according to the WHO standards, and compared to the control group of 54 subjects with no prior oxytocin treatment. RESULTS: No significant difference was noted between the two groups concerning ejaculation time and semen parameters. CONCLUSIONS: Although the administration of oxytocin stimulates sexual behavior and performance in mammalian species, our data indicate that oxytocin has no detectable effect on ejaculation time and seminal parameters after intranasal application in normal, healthy men.
Subject(s)
Ejaculation/drug effects , Oxytocin/administration & dosage , Spermatozoa/drug effects , Spermatozoa/metabolism , Administration, Intranasal , Adult , Humans , Male , Middle Aged , Prospective StudiesABSTRACT
PURPOSE: To evaluate the causes of retinal detachment after silicone oil removal, to define possible risk factors and the anatomical and functional prognosis of this complication. METHODS: 112 eyes that underwent silicone oil removal were included. The group of eyes with retinal detachment after oil removal (18/112 eyes, 16.1%) was compared with the group with no postoperative retinal detachment. RESULTS: The most common cause for retinal detachment after oil removal was anterior PVR (77.8%). Initial PVR detachment, advanced PVR stages, anterior PVR, more preceding operations, aphakia/pseudophakia, myopia and shorter duration of the oil tamponade were significantly more represented in the group of eyes with retinal detachment after oil removal. The prognosis of retinal detachment after oil removal is poor. CONCLUSION: Some criteria could be regarded as risk factors for retinal detachment after silicone oil removal. Improvement of the results should be possible by considering these factors and by control of reproliferations.
Subject(s)
Drainage/adverse effects , Retinal Detachment/etiology , Silicone Oils , Adolescent , Adult , Aged , Child , Female , Humans , Male , Middle Aged , Refractive Errors/complications , Retinal Diseases/surgery , Retrospective Studies , Risk Factors , Visual Acuity , Vitrectomy , Vitreoretinopathy, Proliferative/complicationsABSTRACT
Cells of leaf explants of a monohaploid potato (Solanum tuberosum) were stimulated to mitosis on a medium with 5-bromodeoxycytidine during a period of 7 days. The cells cycled with mono- or diplochromosomes which showed differential staining of the sister chromatids and sister chromatid exchanges by the fluorescent plus Giemsa technique after two rounds of BrdC incorporation. Through the staining pattern the course of the first three cell cycles could be traced and the duration of the cycles estimated. Polyploidisation was enhanced by selective stimulation of polyploid cells and by endoreduplication of G2-phase cells. The percentage of polyploid mitoses increased from 10 to 70.
