1.
Cell Mol Life Sci
; 65(19): 3058-73, 2008 Oct.
Article
in English
| MEDLINE
| ID: mdl-18563293
ABSTRACT
Src-family kinases are modular signaling proteins involved in a diverse array of cellular processes. All members of the Src family share the same domain organization, with modular SH3, SH2 and kinase domains followed by a C-terminal negative regulatory tail. X-ray crystallographic analyses of several Src family members have revealed critical roles for the SH3 and SH2 domains in the down-regulation of the kinase domain. This review focuses on biological, biophysical, and computational studies that reveal conformationally distinct active states within this unique kinase family.
Subject(s)
src-Family Kinases/chemistry , src-Family Kinases/metabolism , Animals , Enzyme Activation , Humans , Models, Molecular , Protein Structure, Tertiary , src Homology Domains , src-Family Kinases/genetics
2.
J Am Chem Soc
; 123(31): 7709-10, 2001 Aug 08.
Article
in English
| MEDLINE
| ID: mdl-11480998