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J Med Chem ; 61(21): 9784-9789, 2018 11 08.
Article in English | MEDLINE | ID: mdl-30351003

ABSTRACT

Chronic pain is currently treated with opioids that offer unsatisfactory long-term analgesia and produce serious side effects. There is a clear need for alternative therapies. Herein, peptide-based hydrogels are used as extended-release drug delivery carriers. Two different formulations were developed: the drug is coformulated within the hydrogel; the drug is an integral part of the hydrogelator. Both strategies afford a prolonged and significant antinociception up to 72 h after subcutaneous administration in mice.


Subject(s)
Drug Carriers/chemistry , Hydrogels/chemistry , Hydrophobic and Hydrophilic Interactions , Oligopeptides/chemistry , Opioid Peptides/chemistry , Opioid Peptides/pharmacology , Amino Acid Sequence , Animals , Drug Carriers/metabolism , Drug Stability , Humans , Mice , Oligopeptides/metabolism
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