Subject(s)
Pemphigus/diagnosis , Pemphigus/drug therapy , Aged , Aged, 80 and over , Antibodies, Monoclonal, Murine-Derived/therapeutic use , Antirheumatic Agents/therapeutic use , Dapsone/therapeutic use , Enzyme-Linked Immunosorbent Assay , Female , Fluorescent Antibody Technique, Indirect , Folic Acid Antagonists/therapeutic use , Humans , Hydroxychloroquine/therapeutic use , Immunologic Factors/therapeutic use , Immunosuppressive Agents/therapeutic use , Male , Prognosis , Remission Induction , Retrospective Studies , Rituximab , Severity of Illness Index , Steroids/therapeutic use , Treatment OutcomeABSTRACT
Lipschütz ulcers are characterised by a first flare of non-sexually related acute genital ulcers (AGU) occurring in adolescent girls. Epstein-Barr primary infection is the most frequently reported aetiology but other infectious agents are probably implicated. We report the first case of mumps associated with an AGU in a 21-year-old girl. She presented a bilateral parotitis with genital ulcers, and serology confirmed she had mumps. As in our case, most Lipschütz ulcers heal spontaneously within a couple of weeks and the diagnosis should be reconsidered in case of recurrence.
Subject(s)
Mumps/complications , Skin Ulcer/diagnosis , Skin Ulcer/etiology , Vulvar Diseases/diagnosis , Acute Disease , Acyclovir/analogs & derivatives , Acyclovir/therapeutic use , Antiviral Agents/immunology , Antiviral Agents/therapeutic use , Female , Humans , Immunoglobulin G/blood , Immunoglobulin G/immunology , Immunoglobulin M/blood , Immunoglobulin M/immunology , Mumps/drug therapy , Mumps/virology , Mumps virus/immunology , Skin Ulcer/drug therapy , Skin Ulcer/virology , Treatment Outcome , Valacyclovir , Valine/analogs & derivatives , Valine/therapeutic use , Vulvar Diseases/drug therapy , Vulvar Diseases/immunology , Vulvar Diseases/virology , Young AdultABSTRACT
Primary cutaneous Epstein-Barr virus-related lymphoproliferative disorders are rare. We describe 4 cases in children: two with acquired immunodeficiencies (HIV infection, heart transplantation) and two with congenital immunodeficiencies (ataxia-telangiectasia and an undetermined disease affecting the T lymphocytes). Two of the lymphoproliferative disorders were T-cell types and two were B-cell types. The two T-cell types were also Epstein-Barr virus positive, which is extremely rare. Three of the patients developed extracutaneous disease with poor outcome, resulting in death.
