ABSTRACT
The purpose of this study was to examine the construct validity of Visual Analogue Scale (VAS)-quality of life for patients with eating disorders in relation to the following instruments: Body Awareness Scale Health, (BAS-H) and its Interview Scale for Body Ego (ISBE), Eating Disturbances Scale (EDS-5), Body Attitude Test (BAT) and Comprehensive Body Examination (CBE), part of respiration, subscale 1. In total 87 individuals were examined: 26 patients with anorexia nervosa (AN), 20 patients with bulimia nervosa (BN) and 41 patients with eating disorders not otherwise specified (EDNOS). The highest significant correlations (0,43-0,61) were found between VAS-quality of life and BAS-H (subscale grounding), variables of EDS-5 (feeling of control and guilt), BAT (subscale 2) and CBE (breathing variables). In conclusion, this study indicated that VAS-quality of life seemed to more accurately capture mental and psychosomatic factors than physical and health-related factors.
Subject(s)
Feeding and Eating Disorders/complications , Feeding and Eating Disorders/psychology , Quality of Life , Adolescent , Adult , Female , Health Status , Humans , Internal-External Control , Male , Psychometrics , Respiration , Surveys and QuestionnairesABSTRACT
The purpose of this study was to identify a method for measuring hand grip endurance in patients with hand injury as well as in healthy subjects. Twenty hand-injured patients and 60 healthy subjects participated in the study. Each subject performed two sets of maximal repetitive isometric contractions on the Grippit instrument for 180 seconds, with a contraction time of 2.5 seconds and a rest time of 1 second. Reliability data were high for initial grip force and for absolute and relative endurance values at 90 seconds (r range, 0.73 to 0.97, p < 0.001). Relative endurance at 180 seconds, though, showed weaker reproducibility (r = 0.54, p < 0.01). A measuring period of 90 seconds instead of 180 seconds is suggested, because of the results of test-retest reliability. The method allows endurance to be described in relative force values (as a percentage) as well as in absolute force values (Newtons).
Subject(s)
Hand Injuries/physiopathology , Hand Strength , Isometric Contraction , Physical Endurance , Adult , Case-Control Studies , Female , Humans , Male , Middle Aged , Reference Values , Reproducibility of Results , Sex Distribution , Sex Factors , Time FactorsSubject(s)
Diabetes Mellitus, Experimental/therapy , Islets of Langerhans Transplantation/physiology , Animals , Blood Glucose/metabolism , Cell Separation , Diabetes Mellitus, Experimental/blood , Humans , Insulin/therapeutic use , Islets of Langerhans/cytology , Islets of Langerhans Transplantation/pathology , Macaca fascicularis , Male , Pancreatectomy , Splenectomy , Transplantation, Heterologous , Transplantation, HomologousSubject(s)
Growth Hormone/adverse effects , Turner Syndrome/drug therapy , Child , Databases, Factual , Female , Humans , Retrospective StudiesABSTRACT
This paper provides an overview of the diagnoses of patients entered in the Kabi Pharmacia International Growth Study (KIGS). By May 1991, data from a total of 5377 children treated with growth hormone (GH) were included in the main database. Of these children, 2691 were classified as having idiopathic GH deficiency (GHD), 866 as having GHD of known origin, and 1820 as having other causes of short stature. The majority of patients with idiopathic GHD have no history of perinatal trauma. In the patients with GHD of known origin, 137 were congenital cases and 729 acquired GHD. The largest number of congenital cases (114) belonged to the group of central malformations (e.g. septo-optic dysplasia and empty sella syndrome). Of the cases with acquired GHD, 73% were associated with tumours or leukaemia. Other causes of short stature include 12 groups of diagnoses, with more than 150 cases in four of them (idiopathic short stature, 635; defined syndromes with chromosomal aberrations, 337, of which 304 were Turner's syndrome; defined syndromes without chromosomal aberrations, 157; intrauterine growth retardation without stigmata, 366). Analysis of the KIGS data allows modern GH therapy for GHD to be compared with older treatment modalities. The study offers the advantage of larger numbers of cases than can be achieved in individual trials and allows assessment of the use of GH therapy for GHD of comparatively uncommon causes.
Subject(s)
Growth Disorders/diagnosis , Body Height , Child , Child, Preschool , Databases, Factual , Female , Follow-Up Studies , Growth Disorders/etiology , Growth Disorders/therapy , Growth Hormone/classification , Growth Hormone/deficiency , Humans , Male , PrognosisSubject(s)
Growth Disorders/drug therapy , Growth Hormone/therapeutic use , Child , Humans , Recombinant ProteinsABSTRACT
A myxoma of the mandibles in an adult female Macaca mulatta is described. The left mandible was markedly enlarged by the tumor, which extended from the symphysis to the temporomandibular joint. The tumor had extended a short distance across the symphysis into the right mandible. It was composed of a glistening mucinous material. Radiographs of the tumor showed a large expansile radiolucent lesion of the left mandible without soft tissue involvement. Light microscopy demonstrated capillaries, stellate shaped cells with processes up to 15 mu long, very few other cell types, and an amorphous ground substance. Electron microscopic examination revealed similarity to the myxoma of bone of man. The oxytalan fibers discovered in this myxoma have not been found in myxomas before and suggest the tumor is odontogenic in origin. The incidence of spontaneous neoplasia in general and that of spontaneous oral tumors in particular in nonhuman primates are reviewed.