ABSTRACT
This article, written by current student trainees within various intramural programs at the National Institutes of Health (NIH), describes how the NIH experience weaves world-class interdisciplinary research into the education of future oral healthcare professionals. This article highlights 4 programs and provides perspectives from current NIH student trainees on the significance of their programs to their career growth in an effort to increase program awareness for faculty and students, thus escalating participation of predental and dental students in programs at the NIH. Although the number of individuals pursuing careers in oral health research has been alarmingly few, dentistry is in a unique position to drastically expand its collaborative scientific workforce. Research must be integrated into the training of increased numbers of future dental professionals. This article describes how NIH programs address specific needs of the dental profession, including reducing disparities, advancing evidence-based personalized medicine, and solving multidisciplinary health challenges.
Subject(s)
Faculty , National Institutes of Health (U.S.) , Humans , United States , WorkforceABSTRACT
As the crucial non-cellular component of tissues, the extracellular matrix (ECM) provides both physical support and signaling regulation to cells. Some ECM molecules provide a fibrillar environment around cells, while others provide a sheet-like basement membrane scaffold beneath epithelial cells. In this Review, we focus on recent studies investigating the mechanical, biophysical and signaling cues provided to developing tissues by different types of ECM in a variety of developing organisms. In addition, we discuss how the ECM helps to regulate tissue morphology during embryonic development by governing key elements of cell shape, adhesion, migration and differentiation.
Subject(s)
Embryonic Development/physiology , Extracellular Matrix/metabolism , Animals , Basement Membrane/metabolism , Cell Adhesion/physiology , Cell Differentiation/physiology , Cell Movement/physiology , Cell Polarity/physiology , Cell Shape/physiology , Female , Humans , Pregnancy , Signal Transduction/physiologyABSTRACT
PURPOSE: To describe prosthetic rehabilitation following partial rhinectomy with use of a novel retentive internal nasal keeper piece. MATERIALS AND METHODS: The reported novel nasal keeper piece engaged the intact inferior portions of the major alar cartilages and the alar fibrofatty tissues to aid in retention of the prosthesis. RESULTS/CONCLUSION: The reported prosthesis utilizes a retentive mechanism not previously reported in the literature to maximize function and esthetics.
