1.
Bioorg Med Chem Lett
; 17(2): 354-7, 2007 Jan 15.
Article
in English
| MEDLINE
| ID: mdl-17095218
ABSTRACT
The synthesis, physicochemical properties and pharmacological profiles of two novel silicon-containing p38 MAP kinase inhibitors are described.
Subject(s)
Enzyme Inhibitors/chemical synthesis , Enzyme Inhibitors/pharmacology , Pyrazoles/chemical synthesis , Pyrazoles/pharmacology , Silicon Compounds/chemistry , p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors , Animals , Chemical Phenomena , Chemistry, Pharmaceutical , Chemistry, Physical , Crystallography, X-Ray , Enzyme Inhibitors/pharmacokinetics , Humans , In Vitro Techniques , Indicators and Reagents , Lipopolysaccharides/pharmacology , Mice , Microsomes, Liver/enzymology , Microsomes, Liver/metabolism , Models, Molecular , Stereoisomerism , Tumor Necrosis Factor-alpha/metabolism
2.
Chem Commun (Camb)
; (20): 2616-7, 2003 Oct 21.
Article
in English
| MEDLINE
| ID: mdl-14594308
ABSTRACT
The relative and absolute stereochemistry of amphidinoketide I has been determined by the total synthesis of all the diastereoisomers. Molecular modelling suggests that the natural product is not the thermodynamically preferred diastereoisomer.
