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2.
Clin Oncol (R Coll Radiol) ; 36(5): 300-306, 2024 05.
Article in English | MEDLINE | ID: mdl-38388251

ABSTRACT

AIMS: Squamous cell carcinoma oral cavity cancers (SCCOCCs) have a higher reported incidence in South Asian countries. We sought to compare presenting stage and outcome by ethnicity in patients with SCCOCC treated with radical radiotherapy in a single centre in the UK. MATERIALS AND METHODS: All patients with SCCOCC treated with radical radiotherapy at an oncology department in Leicester (UK) between 2011 and 2017 were identified. Baseline demographic, clinical data and 2-year treatment outcomes were reported. RESULTS: Of the 109 patients included, 40 were South Asian and 59 were non-South Asian. South Asians had significantly poorer 2-year disease-free survival compared with non-South Asians (54.6% versus 73%, P = 0.01). CONCLUSION: Our analysis suggests that South Asians with SCCOCC have poorer outcomes despite a younger age and similar disease characteristics. Environmental, social factors and differing biology of disease may be responsible and further research is required to inform targeted interventions.


Subject(s)
Asian People , Mouth Neoplasms , Humans , Ethnicity , Treatment Outcome , Mouth Neoplasms/ethnology , United Kingdom
4.
Ophthalmologe ; 107(7): 660-2, 2010 Jul.
Article in German | MEDLINE | ID: mdl-20024561

ABSTRACT

BACKGROUND: Waardenburg syndrome (WS) is a rare disease characterized by a sensorineural hearing loss and pigment anomalies of the iris, skin and hair due to mutations in PAX3. WS can be subdivided into four groups according to major and minor clinical signs. CASE REPORT: We report the case of a 2 1/2-year-old coloured patient who presented in our department of paediatric ophthalmology for a syndrome search. The patient presented with hearing loss, brilliant blue iris colour and dystopia canthorum. The patient was slightly hypermetropic. Visual acuity was within normal limits according to the Cardiff acuity test. The ocular fundus examination revealed no abnormalities. CONCLUSION: According to the major and minor criteria defined by the Waardenburg consortium our patient showed the major criteria of WS1, i.e. hearing loss, hypopigmentation of the pigment epithelium of the iris and dystopic canthi. Diagnosis of WS is usually based on the clinical presentation. An additional molecular genetic analysis is possible.


Subject(s)
Retinal Diseases/diagnosis , Waardenburg Syndrome/diagnosis , Child, Preschool , Humans , Male , Vision Disorders/diagnosis
5.
Ophthalmologe ; 106(11): 1024-8, 2009 Nov.
Article in German | MEDLINE | ID: mdl-19585124

ABSTRACT

A 27-year-old female patient reported a variable but unsatisfactory visual acuity which had persisted for several years. The patient had been dependent on dialysis from the age of 14 years old and from then on also needed a hearing aid. A kidney had been transplanted 5 years ago. The diagnosis was anterior lenticonus due to Alport syndrome.


Subject(s)
Kidney Transplantation/adverse effects , Lens Diseases/diagnosis , Lens Diseases/etiology , Nephritis, Hereditary/complications , Nephritis, Hereditary/surgery , Vision Disorders/diagnosis , Vision Disorders/etiology , Adult , Diagnosis, Differential , Female , Humans
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