An integrated group decision-making method for the evaluation of hypertension follow-up systems using interval-valued q-rung orthopair fuzzy sets.

It is imperative to comprehensively evaluate the function, cost, performance and other indices when purchasing a hypertension follow-up (HFU) system for community hospitals. To select the best software product from multiple alternatives, in this paper, we develop a novel integrated group decision-making (GDM) method for the quality evaluation of the system under the interval-valued q-rung orthopair fuzzy sets (IVq-ROFSs). The design of our evaluation indices is based on the characteristics of the HFU system, which in turn represents the evaluation requirements of typical software applications and reflects the particularity of the system. A similarity is extended to measure the IVq-ROFNs, and a new score function is devised for distinguishing IVq-ROFNs to figure out the best IVq-ROFN. The weighted fairly aggregation (WFA) operator is then extended to the interval-valued q-rung orthopair WFA weighted average operator (IVq-ROFWFAWA) for aggregating information. The attribute weights are derived using the LINMAP model based on the similarity of IVq-ROFNs. We design a new expert weight deriving strategy, which makes each alternative have its own expert weight, and use the ARAS method to select the best alternative based on these weights. With these actions, a GDM algorithm that integrates the similarity, score function, IVq-ROFWFAWA operator, attribute weights, expert weights and ARAS is proposed. The applicability of the proposed method is demonstrated through a case study. Its effectiveness and feasibility are verified by comparing it to other state-of-the-art methods and operators.

Autoregressive count data modeling on mobility patterns to predict cases of COVID-19 infection.

At the beginning of 2022 the global daily count of new cases of COVID-19 exceeded 3.2 million, a tripling of the historical peak value reported between the initial outbreak of the pandemic and the end of 2021. Aerosol transmission through interpersonal contact is the main cause of the disease's spread, although control measures have been put in place to reduce contact opportunities. Mobility pattern is a basic mechanism for understanding how people gather at a location and how long they stay there. Due to the inherent dependencies in disease transmission, models for associating mobility data with confirmed cases need to be individually designed for different regions and time periods. In this paper, we propose an autoregressive count data model under the framework of a generalized linear model to illustrate a process of model specification and selection. By evaluating a 14-day-ahead prediction from Sweden, the results showed that for a dense population region, using mobility data with a lag of 8 days is the most reliable way of predicting the number of confirmed cases in relative numbers at a high coverage rate. It is sufficient for both of the autoregressive terms, studied variable and conditional expectation, to take one day back. For sparsely populated regions, a lag of 10 days produced the lowest error in absolute value for the predictions, where weekly periodicity on the studied variable is recommended for use. Interventions were further included to identify the most relevant mobility categories. Statistical features were also presented to verify the model assumptions.

Curcumin alleviates lipopolysaccharides-induced inflammation and apoptosis in vascular smooth muscle cells via inhibition of the NF-κB and JNK signaling pathways.

Curcumin plays an important role in inflammation regulation. This study aimed to investigate the effect of curcumin on vascular smooth muscle cells (VSMCs) inflammation induced by lipopolysaccharide (LPS) and its mechanism. VSMCs were treated with different concentrations of curcumin (0, 50, 100 and 150 µg/mL). MTT assay and flow cytometry were used to analyze the effects of curcumin on LPS-induced VSMCs viability and apoptosis. The expression and release of inflammatory cytokines in VSMCs were detected by real-time quantitative polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA). Moreover, the proteins expressions of NF-κB and JNK signaling pathways were analyzed by western blot. Interestingly, the results showed that curcumin could reduce LPS induced inflammatory injury by increasing VSMC's viability, reducing apoptosis and inhibiting the release of inflammatory cytokines. In addition, curcumin increased the expression of Toll-like receptor 4 (TLR4) in LPS treated VSMCs. Mechanistically, we found that curcumin attenuated LPS-induced cell damage in VSMCs via inhibition of NF-κB and the JNK signal pathway. Curcumin can protect VSMCs from LPS induced inflammatory damage, which may be related to the blocking of NF-κB and the JNK signaling pathway. Herewith, curcumin could be potential therapeutics for the treatment of atherosclerosis.

A Comparative Study of Common Nature-Inspired Algorithms for Continuous Function Optimization.

Over previous decades, many nature-inspired optimization algorithms (NIOAs) have been proposed and applied due to their importance and significance. Some survey studies have also been made to investigate NIOAs and their variants and applications. However, these comparative studies mainly focus on one single NIOA, and there lacks a comprehensive comparative and contrastive study of the existing NIOAs. To fill this gap, we spent a great effort to conduct this comprehensive survey. In this survey, more than 120 meta-heuristic algorithms have been collected and, among them, the most popular and common 11 NIOAs are selected. Their accuracy, stability, efficiency and parameter sensitivity are evaluated based on the 30 black-box optimization benchmarking (BBOB) functions. Furthermore, we apply the Friedman test and Nemenyi test to analyze the performance of the compared NIOAs. In this survey, we provide a unified formal description of the 11 NIOAs in order to compare their similarities and differences in depth and a systematic summarization of the challenging problems and research directions for the whole NIOAs field. This comparative study attempts to provide a broader perspective and meaningful enlightenment to understand NIOAs.

Partial Classifier Chains with Feature Selection by Exploiting Label Correlation in Multi-Label Classification.

Multi-label classification (MLC) is a supervised learning problem where an object is naturally associated with multiple concepts because it can be described from various dimensions. How to exploit the resulting label correlations is the key issue in MLC problems. The classifier chain (CC) is a well-known MLC approach that can learn complex coupling relationships between labels. CC suffers from two obvious drawbacks: (1) label ordering is decided at random although it usually has a strong effect on predictive performance; (2) all the labels are inserted into the chain, although some of them may carry irrelevant information that discriminates against the others. In this work, we propose a partial classifier chain method with feature selection (PCC-FS) that exploits the label correlation between label and feature spaces and thus solves the two previously mentioned problems simultaneously. In the PCC-FS algorithm, feature selection is performed by learning the covariance between feature set and label set, thus eliminating the irrelevant features that can diminish classification performance. Couplings in the label set are extracted, and the coupled labels of each label are inserted simultaneously into the chain structure to execute the training and prediction activities. The experimental results from five metrics demonstrate that, in comparison to eight state-of-the-art MLC algorithms, the proposed method is a significant improvement on existing multi-label classification.