1.
Nat Prod Res
; 28(14): 1070-4, 2014.
Article
in English
| MEDLINE
| ID: mdl-24735402
ABSTRACT
One new naphthalene derivative, 1,8-dihydroxynaphthol-1-O-α-l-rhamnopyranoside (1), together with one known α-dibenzopyrone, alternariol (2), and five xanthones (3-7) were isolated from the sponge-derived fungus Arthrinium sp. ZSDS1-F3. All the isolated compounds (1-7) were established by comprehensive analysis of the spectral data, especially 1D and 2D NMR (HMQC and HMBC) spectra. In the primary bioassays, compound 3 exhibited moderate COX-2 inhibition, with IC50 values of 12.2 µM.
Subject(s)
Ascomycota/chemistry , Cyclooxygenase 2 Inhibitors/isolation & purification , Glycosides/isolation & purification , Naphthols/isolation & purification , Porifera/microbiology , Xanthones/isolation & purification , Animals , Cyclooxygenase 2 Inhibitors/chemistry , Cyclooxygenase 2 Inhibitors/pharmacology , Glycosides/chemistry , Glycosides/pharmacology , Inhibitory Concentration 50 , Molecular Structure , Naphthols/chemistry , Naphthols/pharmacology , Nuclear Magnetic Resonance, Biomolecular , Xanthones/chemistry , Xanthones/pharmacology
2.
J Antibiot (Tokyo)
; 67(8): 581-3, 2014 Aug.
Article
in English
| MEDLINE
| ID: mdl-24736857
