Assessment of coastal eco-environmental sustainable development under multiple pressures: A case study of Jiaozhou Bay, China.

The increasing demand for economic development in the coastal zone is exerting greater pressure on the eco-environment in this region. Therefore, it is imperative to conduct comprehensive research on the sustainable development of the eco-environment in coastal areas. Grounded in sustainable development theory and Integrated Coastal Zone Management (ICZM), this study assessed sustainable development of Jiaozhou Bay (JZB), China over the period from 2015 to 2019 under multiple pressures applying the Driver-Pressure-State-Impact-Response (DPSIR) framework. Subsequently, a SWOT (Strengths, Weaknesses, Opportunities and Threats) analysis was employed to propose specific countermeasures and recommendations. In terms of weight within the criterion layer, Response (R) and Pressure (P) were assigned higher weights. The comprehensive assessment value Z in the target layer indicated a slight decrease in 2016 followed by a gradual increase that eventually led to stabilization. The comprehensive assessment values of the indicators varied depending on different conditions, implying that higher values would contribute to sustainable development of the eco-environment. Based on a SWOT analysis, strategies for Qingdao were derived from a combination of research findings and future development policy. These strategies include preventing and controlling land and sea pollution, governing reclamation activities, optimizing industrial structure, and strengthening public opinion guidance. This study highlights the application of quantitative and qualitative analysis methods in ICZM, providing specific recommendations based on policy analysis for achieving sustainable development in JZB's eco-environment under multiple pressures.

Evaluation of the coordinated development level in the coastal eco-environmental complex system: A case study of Jiaozhou Bay, China.

Given the exponential population growth and remarkable socio-economic advancements, coastal areas face increasingly complex challenges in eco-environmental management due to anthropogenic pressures. With the current emphasis on high-quality economic development, there is an urgent need to establish and evaluate a comprehensive indicator system to ensure the sustainable development of the coastal eco-environment and to meet evolving management demands. Research on the coordinated development level of coastal eco-environmental complex system, based on the concept of land-sea coordination, plays a pivotal role in promoting the resolution of eco-environmental issues in coastal areas, achieving sustainable socio-economic development in these regions. In this study, we construct an indicator system for the eco-environmental complex system in Jiaozhou Bay (JZB) coastal zone, China, comprising six sub-systems and thirty indicators. The comprehensive development level and coupling coordination degree model (CCDM) are employed in this study to analyze the indicator system in 1980-2020, aiming to elucidate the processes involved in the improvements in this complex system. The findings indicate: (i) the system's comprehensive development level evaluation and coupling coordination degree (CCD) exhibit a two-stage pattern: a declining trend in 1980-2005, followed by a rising trend in 2005-2020. (ii) despite improvements, the comprehensive development level and the CCD of the system in 2020 still hold potential for further enhancement compared to 1980; and (iii) policymaking and changes in anthropogenic pressures in coastal areas are the primary factors influencing the performance of the system. In the future, policymaking can reduce anthropogenic pressures on the coastal eco-environment, improve the comprehensive development level and CCD of the complex system, and encourage a commitment to sustainable development.

The combination of berberine and cinnamon polyphenol can improve glucose metabolism in T2DM rats through Bas-TGR5-GLP-1 / 药学学报

Berberine (BBR) is the main pharmacological active ingredient of Coptidis, which has hypoglycemic effect, but its clinical application is limited due to its poor oral bioavailability. Polyphenols, derived from cinnamon, are beneficial for type 2 diabetes mellitus (T2DM). The combination of both may have an additive effect. The aim of this study was to investigate the hypoglycemic effect and mechanism of combined medication in diabetic rats. The modeling rats were randomly divided into 5 groups (berberine group, cinnamon group, combined group, metformin group, diabetic control group) and normal control group. The animal experiments were approved by the Animal Ethics Committee (approval number: HMUIRB2022003). The subjects were given orally, and the control group was given equal volume solvent and body weight was measured weekly. Thirty days after administration, oral glucose tolerance test and insulin sensitivity test were performed, and fasting blood glucose (FBG), glycated serum protein (GSP), and serum insulin (INS) levels were detected; high-throughput sequencing technology was used to detect intestinal microbiota structure; real-time quantitative PCR (RT-qPCR) and Western blot were used to detect G protein-coupled receptor 5 (TGR5) and glucagon-like peptide-1 (GLP-1) expression levels. The results showed that, compared with the diabetic control group, the levels of FBG (P < 0.01) and GSP (P < 0.01) in the combined group were lower, and the insulin resistance was improved, which was better than that in the berberine group. Combined treatment increased the relative abundance of Bacteroides, Prevotella and Lactobacillus, reversed the decrease in Lactobacillus in the berberine alone induction group, and the combination of the two could promote the expression of TGR5 and GLP-1. In summary, the combined application of cinnamon and berberine can regulate glucose metabolism better than the application of berberine alone. Berberine combined with cinnamon can improve the function of pancreatic islet β cells in diabetes mellitus type 2 rats by changing the intestinal microbiota, increasing the expression of TGR5 and GLP-1 proteins, and thereby better regulating glucose metabolism.

Impact of autonomic nerve function on motor function in patients with post-stroke depression / 中国康复理论与实践

ObjectiveTo explore the impact of autonomic nerve function on motor function in patients with post-stroke depression (PSD) from the perspective of regional homogeneity (ReHo). MethodsFrom January to December, 2020, a total of 60 inpatients and outpatients with cerebral infarction in the Affiliated Brain Hospital of Nanjing Medical University were divided into control group (n = 30) and PSD group (n = 30). Two groups were assessed using Fugl-Meyer Assessment (FMA), modified Barthel Index (MBI) and Hamilton Depression Scale (HAMD). Heart rate variability (HRV) was measured. Ten patients in each group were selected randomly to undergo resting state functional magnetic resonance imaging (rs-fMRI) to calculate ReHo. ResultsAll HRV indices were lower in PSD group than in the control group (|t| > 2.092, P < 0.05). In PSD group, FMA and MBI scores showed positive correlations with 24-hour standard deviation of normal-to-normal R-R intervals (SDNN), the root mean square of successive differences between normal heartbeats over 24 hours (RMSSD), the percentage of differences between adjacent normal R-R intervals over 24 hours that were greater than 50 ms (PNN50), total power (TP), very low frequency power (VLF) and low frequency power (LF) (r > 0.394, P < 0.05), and showed negative correlations with HAMD scores (|r| > 0.919, P < 0.001). HAMD scores in PSD group were negatively correlated with SDNN, RMSSD, PNN50, TP and VLF (|r| > 0.769, P < 0.001). Compared with the control group, the ReHo increased in PSD group in the right rectus gyrus (142 voxels, t = 6.575), the left medial and paracingulate gyri (204 voxels, t = 4.925) (GRF correction, P-Voxel < 0.005，P-Cluster < 0.05); and reduced in the right cerebellum (191 voxels, t = -6.487), the left middle temporal gyrus (140 voxels, t = -5.516), and the left precentral gyrus (119 voxels, t = -4.764) (GRF correction, P-Voxel < 0.005，P-Cluster < 0.05) in PSD group. ConclusionAutonomic nerve function is related to motor dysfunction in patients with PSD. The modulation of emotional, cognitive and motor brain regions by the autonomic nervous system may play a role in influencing the motor function in patients with PSD.

In-situ electrodeposited Co0.85Se@Ni3S2 heterojunction with enhanced performance for supercapacitors.

Rational design of porous heterostructured electrode materials for high-performance supercapacitors remains a big challenge. Herein, we report the in situ synthesis of Co0.85Se@Ni3S2 hybrid nanosheet arrays supported on carbon cloth (CC) substrate though an efficient two-step electrodeposition method. Compared with pure Co0.85Se and Ni3S2, the well-defined Co0.85Se@Ni3S2 heterojunction possesses enriched active sites, improved electrical conductivity, and reduced ion diffusion resistance. Benefiting from its hierarchically porous nanostructure and the synergistic effect of Co0.85Se and Ni3S2, the as-synthesized Co0.85Se@Ni3S2 electrode delivers a gravimetric capacitance (Cg)/volumetric capacitance (Cv) of 1644.1F g-1/3161.7F cm-3 at 1 A g-1, outstanding rate capability of 60.7% capacitance retention at 20 A g-1, as well as good cycling performance of 87.8% capacitance retention after 5000 cycles. Additionally, a hybrid supercapacitor (HSC) device presents a maximum energy density (E) of 65.7 Wh kg-1 at 696.2 W kg-1 with 93.3% cyclic durability after 15,000 cycles. Thus, this work proposes a simple and effective strategy to fabricate porous heterojunctions as high-performance electrode materials for energy storage devices.

Constructing nickel sulfide @ nickel boride hybrid nanosheet arrays with crystalline/amorphous interfaces for supercapacitors.

Designing a heterostructure with unique morphology and nanoarchitecture is regarded as an efficient strategy to achieve high-energy-density supercapacitors (SCs). Herein, a rational nickel sulfide @ nickel boride (Ni9S8@Ni2B) heterostructure is in situ synthesized on carbon cloth (CC) substrate via a simple electrodepositon strategy followed by a chemical reduction method. The three-dimensional hierarchically porous Ni9S8@Ni2B nanosheet arrays, consisting of crystalline Ni9S8 nanosheets and amorphous Ni2B nanosheets, can expose ample electroactive centers, shorten ion diffusion distance, and buffer volume changes during charging/discharging process. More importantly, the generation of crystalline/amorphous interfaces in the Ni9S8@Ni2B composite modulates its electrical structure and improves electrical conductivity. Owing to the synergy of Ni9S8 and Ni2B, the as-synthesized Ni9S8@Ni2B electrode acquires a specific capacity of 901.2C g-1 at 1 A g-1, a sound rate capability (68.3% at 20 A g-1), along with good cycling performance (79.7% capacity retention over 5000 cycles). Additionally, the assembled Ni9S8@Ni2B//porous carbon asymmetric supercapacitor (ASC) exhibits a cell voltage of 1.6 V and a maximum energy density of 59.7 Wh kg-1 at 805.2 W kg-1. These findings might offer a simple and innovative approach to fabricate advanced electrode materials for high-performance energy storage systems.

Structurally-stable Mg-Co-Ni LDH grown on reduced graphene by ball-milling and ion-exchange for highly-stable asymmetric supercapacitor.

As an electrode for energy storage, the inherently poor conductivity of metal hydroxides (MHs) can be improved by in situ growth of MHs on conductive carbon based substrates so that their performances on energy storage could be enhanced to a high level. However, the incompatibility of hydrophilic component (metal hydroxides) and hydrophobic counterpart (carbon based materials) makes it difficult to be accomplished. Herein, we presented a scalable and easy-operated strategy by ball-milling combined with ion-exchange technique to grow Mg-Co-Ni LDH (layered double hydroxides) on reduced graphene, in which ball-milling was utilized to disperse the staring material of magnesium acetate on graphene oxide (GO) to obtain the composite of Mg(Ac)2/GO. The composite can be in situ transformed to MgO/reduced grapheme (rG) by following heat treatment. While, the ion-exchange reaction could enables the in situ growth of Mg-Co-Ni LDHs on the reduced graphene. The derived products (denoted as Mg-Co-Ni LDH/rG-x) owns nanosheet morphology, surface area of 59-115 m2/g, homogenous elements distribution. As electrode for supercapacitor, the maximum capacitance of 1204F/g@1.0 A/g was achieved and the corresponding asymmetric supercapacitor device shows a large energy density of 44.3 Wh/kg@800 W/kg. Particularly, a superlong cycling stability with 90.5% capacitance retention of the first cycle was attained after continuous charge/discharge for 20 000 cycles at current density of 5.0 A/g, promising great potential for practical energy storage application. The present strategy is simple and scalable that can be widely applied to the synthesis of various hydroxides/oxides or multi-component hydroxides/oxides on carbon substrates forming a composite structure, thus offers a great potential for broad application areas including catalysis, adsorption, energy storage, etc.

Mushroom-like cobalt nickle metaphosphate@nickel diselenide core-shell nanorods for asymmetric supercapacitors.

Although transition metal metaphosphates (TMPOs) display special physical/chemical features and high theoretical capacities, their applications for supercapacitors (SCs) are still restricted by their low energy densities and inferior cycling stability. Herein, a novel strategy has been proposed to address these issues through in situ construction of cobalt nickle metaphosphate (Co0.2Ni0.8(PO3)2)@nickel diselenide (NiSe2) core-shell heterostructure on carbon paper (CP) as a self-supporting flexible electrode for SCs. Particularly, this unique mushroom-like porous nanoarchitecture assembled by one-dimensional (1D) Co0.2Ni0.8(PO3)2 nanorods and zero-dimensional (0D) NiSe2 nanospheres can expose abundant active sites and afford multi-dimensional channels, which favors rapid electron ions/electron transfer, accelerates the reaction kinetics, and alleviates volume changes during charging/discharging processes. Profiting from its well-aligned 1D/0D nanostructure and strong synergistic effect between Co0.2Ni0.8(PO3)2 and NiSe2, the Co0.2Ni0.8(PO3)2@NiSe2/CP electrode delivers a specific capacity of 219.4 mAh/g/0.414 mAh cm-2 at 1 A/g and good cycling stability with capacity retention of 90.7% after 5000 cycles, outperforming many previously reported TMPO-based electrodes in literature. Impressively, an asymmetric supercapacitor (ASC) device assembled with Co0.2Ni0.8(PO3)2@NiSe2 as cathode and porous carbon as anode achieves an energy density of 69.2 Wh kg-1 at 736.0 W kg-1 and maintains a capacity retention of 97.6% after 20,000 charge-discharge cycles. This work provides an efficient approach to design multi-dimensional hybrid nanomaterials for high-performance SCs.

Two-step electrodeposition synthesis of iron cobalt selenide and nickel cobalt phosphate heterostructure for hybrid supercapacitors.

Exploring novel heterostructure with multiscale nanoarchitectures and modulated electronic structure is crucial to improve the electrochemical properties of electrode materials for supercapacitors (SCs). In this study, a two-step electrodeposition approach which involves suitable efficient procedures, is leading to in-situ preparation of iron cobalt selenide (Fe0.4Co0.6Se2) @ nickel cobalt phosphate (NiCo(HPO4)2·3H2O, denoted as NiCo-P) hybrid nanostructure on carbon cloth (CC) substrate. Particularly, depositing two-dimensional (2D) NiCo-P nanosheets on the surface of Fe0.4Co0.6Se2 nanobelts results in formation of well-organized Fe0.4Co0.6Se2@NiCo-P nanocomposite with large surface area, hierarchical porous nanoarchitecture as well as numerous electroactive sites, leading to enhanced electroactivity and accelerated mass/electron transfer. Benefiting from its unique nanoarchitecture and synergistic effect of two components, the obtained free-standing Fe0.4Co0.6Se2@NiCo-P electrode demonstrates gravimetric capacity (Cm)/volumetric capacity (Cd) of 202.3 mAh/g/319.6 mAh cm-3 at 1 A g-1 and good cyclic stability (83.9% capacity retention over 5000 cycles), which are superior to those of pure Fe0.4Co0.6Se2 and NiCo-P electrodes. Impressively, it was established that an aqueous hybrid supercapacitor (HSC) based on Fe0.4Co0.6Se2@NiCo-P and rape pollen derived hierarchical porous carbon (RPHPC) achieves gravimetric energy density (Em)/volumetric energy density (Ed) of 64.4 Wh kg-1/10.7 mWh cm-3 and a long cycle life with 90.3% capacity retention over 10,000 cycles. This report offers a perspective to design selenide/phosphate heterostructure on conducting substrate for electrochemical energy storage applications.

Superbases-templated carbons doped with electrochemically active oxygen as advanced supercapacitor electrodes.

Templating techniques have been widely adopted for the synthesis of porous carbons, such as oxygen-doped porous carbon nanosheets (O-PCNs), but the effect of the surface characteristics of templates on the surface functionality and performance of a derived carbon has not been well studied. Herein, a series of laboratory-made superbases of K/Mg(OH)2 with different K/Mg ratios were employed as template to fabricate nanocarbon materials. The aim is to find out how the strength of template basicity could influence the surface functionalities and the supercapacitor performances of the derived O-PCNs. The resulting materials are rich in conjugated hydroxyl and carbonyl groups that are electrochemically active owing to the protection of the conjugated hydroxyl group by KOH and the dehydrogenation step catalyzed by magnesium oxide. Systematic investigations revealed that with the increase of basic strength, the content of the derived electrochemically active oxygen species in the forms of conjugated carbonyl (CO) and hydroxyl (COH) first increases from 8.4 atom% to 11.4 atom% then decreases to 9.25 atom%. Moreover, the microporosity of the O-PCNs stepwise increases with the rise of KOH loading, ascribable to the effect of KOH etching on the carbon skeleton. The O-PCN-20 templated by 20 % K/Mg(OH)2 is rich in porosity, large in surface area (930 m2/g) and high in active oxygen content (11.4 atom%). With high active surface area and extra Faradaic capacitance, O-PCN-20 exhibited superior supercapacitor performances including large specific capacitance of 375 F/g@1.0 A/g, high rate capability of 81.1 % (from 1.0 A/g to 20 A/g), energy density of 25.7 Wh/kg@900 W/kg and excellent cycling stability with near 100 % capacitance retentions after 10 000 cycles and more than 86.2 % capacitance retention over 20 000 cycles at large current density of 10 A/g, indicating O-PCN-20 has potential to be used as electrode material for energy storage devices.

1D-on-1D core-shell cobalt iron selenide @ cobalt nickel carbonate hydroxide hybrid nanowire arrays as advanced battery-type supercapacitor electrode.

Sluggish kinetics and poor structural stability are two main obstacles hampering the exploration of transition metal selenides (TMSs) for supercapacitor. Developing a reasonable core-shell heterostructure with unique morphology is an effective approach to resolve these issues. Herein, a core-shell cobalt iron selenide (CoFe2Se4) @ cobalt nickel carbonate hydroxide (CoNi-CH) heterostructure is directly fabricated on carbon cloth via an electrodeposition method followed by a hydrothermal reaction. In this well-defined heterostructure, one-dimensional (1D) CoFe2Se4 nanowires function as the cores and CoNi-CH nanowires as the shells, which combines the merits of highly conductive CoFe2Se4 for rapid electron transfer and highly electroactive CoNi-CH for multiple redox reactions. Further, the intimate interaction between CoNi-CH and CoFe2Se4 realizes large surface area with hierarchical network and generates rich heterointerfaces with modified the electronic structure. By virtue of its facile 1D-on-1D nanoarchitecture and synergistic effect, the CoFe2Se4@CoNi-CH electrode delivers a increased specific capacity of 218.6 mAh g-1 at 1 A-1 and enhanced rate capability (65.5% at 20 A g-1) compared with pure CoFe2Se4 and CoNi-CH. Besides, a hybrid supercapacitor is established by coupling CoFe2Se4@CoNi-CH cathode and porous carbon anode, which enjoys a maximum energy density of 67.3 Wh kg-1 at 765.9 W kg-1 and prominent durability with 85.4% of capacity retention over 20,000 cycles.

Nickel cobalt sulfide coated iron nickel selenide hierarchical nanosheet arrays toward high-performance supercapacitors.

Tailoring the electronic structure of nanomaterials by constructing core-shell heterostruture is a compelling strategy to design novel electrode materials with modified physiochemical properties for supercapacitors with improved performance. Herein, for the first time, we in situ fabricate iron nickel selenide (FeNiSe2)@nickel cobalt sulfide (Ni4.5Co4.5S8) core-shell nanosheet arrays on carbon cloth by an electrodeposition approach and a selenization treatment. This three-dimensional hierarchcial porous framework formed by plentiful interconnected nanosheets can expose numerous redox active sites with varied oxidation states and provide a conductive and porous skeleton for rapid ion/electrolyte ions transport. Benefiting from its modulated electronic structure and synergetic effect of metal-like FeNiSe2 and Ni4.5Co4.5S8, the as-synthesized FeNiSe2@Ni4.5Co4.5S8 electrode displays a large specific capacity of 236.9 mAh g-1 at 1 A g-1, remarkable rate capability with 80.6% capacity retention at 20 A g-1, and stable cyclic performance, which are superior to those of pure FeNiSe2 and Ni4.5Co4.5S8 electrodes. Besides, the assembled FeNiSe2@Ni4.5Co4.5S8//porous carbon hybrid supercapacitor device offers an energy density of 69.0 Wh kg-1 at 799.2 W kg-1, and exceptional cycling stability with 91.2% capacity retention after 10,000 cycles. This work offers a synthetic strategy to explore core-shell electrode materials with tunable architecture and morphology for high-performance energy storage devices.

Association between UBAC2 gene polymorphism and the risk of noise-induced hearing loss: a cross-sectional study.

The purpose of this article was to investigate the association between the ubiquitin-associated domain-containing protein 2 (UBAC2) gene polymorphism and noise-induced hearing loss (NIHL) and to further explore the role of single-nucleotide polymorphism (SNP) in UBAC2 in NIHL. A case control study involving 660 NIHL cases and 581 controls was conducted in this research. After genotyping by multiplex polymerase chain reaction (PCR) with next-generation sequencing, the correlation between SNPs and NIHL was analyzed using logistic regression analysis. Haplotype analysis was performed by Haploview 4.1 software. Then luciferase reporter assays and siRNA were used to explore the mechanism of SNPs in UBAC2 affecting NIHL susceptibility. The correlation analysis showed that rs3825427 AA genotype, rs9517701 GG genotype, rs7999348 GG genotype, and rs2296860 AA genotype were all associated with increased risk of NIHL (P < 0.05). The haplotype AGGA (rs3825427-rs9517701-rs7999348-rs2296860) also had a higher risk of NIHL (OR = 1.314; 95% CI, 1.098-1.572; P = 0.003). The results of the luciferase reporter assays showed that the fluorescence intensity of CTCF-OE + UBAC2 WT + TK was significantly higher than that of CTCF-NC + UBAC2 WT + TK and CTCF-OE + UBAC2 MT + TK (all P < 0.01). In CTCF knockdown cells, the expression of UBAC2 was also significantly downregulated (P = 0.0038), indicating that the transcription factor CTCF positively regulated the expression of UBAC2 and the rs3825427 C allele acted as an enhancer, which can promote CTCF to bind to the promoter of UBAC2, thereby promoting transcription. UBAC2 gene polymorphism is related to NIHL susceptibility. The UBAC2 rs3825427 regulates the expression level of UBAC2 by affecting the combination of CTCF and DNA, thus affecting the susceptibility of NIHL.

Associations of genetic variation in E3 SUMO-protein ligase CBX4 with noise-induced hearing loss.

Noise-induced hearing loss (NIHL) is a multifactorial disease caused by environmental, genetic and epigenetic variables. SUMOylation is a post-translational modification that regulates biological processes. The objective of this study was to determine the link between genetic variation in the chromobox 4 (CBX4) and the risk of NIHL. This study applied a case-control design with 588 cases and 582 controls, and the sample was predominantly male (93.76%). The T allele of CBX4 rs1285250 was found to be significantly linked with NIHL (P = 0.002) and showed strong associations in both the codominant and recessive models (TT versus CC, P = 0.005; TT/TC versus CC, P = 0.009). By constructing a mouse model of hearing loss because of noise exposure, changes in hearing thresholds were observed in noise-exposed mice, along with a decrease in the number of cochlear hair cells. Furthermore, noise promotes cochlear hair cell apoptosis by inducing SP1/CBX4 pathway activation. Further functional studies demonstrated that SP1 has an influence on the promoter activity of the CBX4 rs1285250 intron, with the promoter activity of the T allele being higher than that of the C allele. Knockdown of transcription factor SP1 reduced the expression of CBX4 expression and simultaneously reduced apoptosis in HEI-OC1 cells. Together, our findings have shown that CBX4 genetic polymorphism rs1285250 T-allele was associated with increased risk of NIHL and might be used as biomarkers for male workers exposed to noise. Furthermore, we speculate that the CBX4 of rs1285250 T-allele leads to a stronger potential enhancer activity from a predicted gain of stronger SP1 binding.

Design of mesoporous Ni-Co hydroxides nanosheets stabilized by BO2- for pseudocapacitors with superior performance.

The investigation of high-efficiency electrodes is essential for the energy conversion/storage devices. In this work, mesoporous two-dimensional Ni-Co hydroxide nanosheets stabilized by BO2- (denoted as (NixCoy)(OH)2/Co(BO2)2) are prepared via a facile and cost-effective procedure to circumvent the shortage of nickel hydroxide, viz. poor conductivity and fast phase transition. The (NixCoy)(OH)2/Co(BO2)2 materials have high specific surface area and plenty of exposed active sites. As electrode, the optimized (Ni0.5Co0.5)(OH)2/Co(BO2)2 delivers a remarkable specific capacity of 2257 F g-1 at 1 A g-1 with superior rate capability (2071 F g-1 at 20 A g-1). Moreover, the asymmetric supercapacitors assembled by (Ni0.5Co0.5)(OH)2/Co(BO2)2 and active carbon provides high energy density (56.5 Wh kg-1 at 0.8 kW kg-1) and excellent cyclic stability (maintaining 98% of initial capacity over 10 000 cycles), demonstrating the promising potential of (Ni0.5Co0.5)(OH)2/Co(BO2)2 in practical applications.

Freestanding trimetallic Fe-Co-Ni phosphide nanosheet arrays as an advanced electrode for high-performance asymmetric supercapacitors.

Transition metal phosphides hold great promise for high performance battery-type electrode materials due to their superb electrical conductivity and high theoretical capacity. Unfortunately, the electrochemical properties of single metal or bimetallic phosphides are unsatisfactory owing to their low energy density and poor cyclic stability, and one feasible approach is to introduce heteroatoms to form trimetallic phosphides. Here, novel Fe-Co-Ni-P nanosheet arrays are in situ synthesized on a flexible carbon cloth substrate via an electrodeposition method followed by a phosphorization treatment. Due to the presence of abundant redox active sites, large specific surface area with mesoporous channels, desirable electrical conductivity, modified electronic structure, and synergistic effect of Fe, Co, and Ni ions, the as-prepared Fe-Co-Ni-P electrode displays significantly enhanced electrochemical performance when compared to bimetallic phosphides Fe-Co-P and Fe-Ni-P. Remarkably, the Fe-Co-Ni-P electrode exhibits a large specific capacity of 593.0 C g-1 at 1 A g-1, exceptional rate performance (80.3% capacity retention at 20 A g-1), and good cycling stability (84.2% capacity retention after 5000cycles). Besides, an asymmetric supercapacitor device with Fe-Co-Ni-P electrode as a positive electrode and a hierarchical porous carbon as a negative electrode shows a high energy density of 57.1 Wh kg-1 at a power density of 768.5 W kg-1 as well as excellent cyclability with 88.4% of initial capacity after 10,000cycles. This work manifests that the construction of trimetallic phosphides is an effective strategy to solve the shortcomings of single or bimetallic phosphides for high-performance supercapacitors.

NiAlP@Cobalt substituted nickel carbonate hydroxide heterostructure engineered for enhanced supercapacitor performance.

Transitional metal phosphides with high electrical conductivity and superb physicochemical features have been recognized as ideal battery-type electrode materials for outstanding performance supercapacitors. However, their specific capacities and structural stability are needed to be enhanced for large-scale practical applications. To overcome these shortcomings, we fabricated heterostructured NiAlP@cobalt substituted nickel carbonate hydroxide (Co-NiCH) nanosheet arrays by sequential a hydrothermal reaction, a phosphorization treatment, and a second hydrothermal reaction. Profiting from its core-shell porous nanostructure and synergistic effect of NiAlP with high electrical conductivity and Co-NiCH with high redox reactivity, the resultant NiAlP@Co-NiCH electrode delivers a large specific capacity of 825.7C g-1 at 1 A g-1, excellent rate capability with 78.9% capacity retention and long lifespan, superior to those of pure NiAlP and Co-NiCH electrodes. Additionally, an aqueous asymmetric supercapacitor device is constructed by NiAlP@Co-NiCH and lotus pollen-derived hierarchical porous carbon, which demonstrates a large energy density of 82.3 Wh kg-1 at a power density of 739.8 W kg-1, and wonderful cycle stability with 88.2% capacity retention after 10,000 cycles. This work proposes a feasible strategy on construction of transitional metal phosphide-based heterojunctions for advanced asymmetric supercapacitor devices.

Effect of nonconsecutive aerobic resistance training on blood glucose and childbirth outcome of women with gestational diabetes mellitus / 中国实用护理杂志

Objective:To investigate applications of nonconsecutive aerobic resistance training among women with gestational diabetes mellitus, to provide reference for pregnancy health care.Methods:The convenient sampling method was adopted, a total of 110 gestational diabetes mellitus pregnant women were selected who established card and regular obstetric check-up in Zhongshan City People's Hospital from June 2019 to June 2020 as the study subjects. They were divided into experimental group and control group according to the random number table method, each group contained 55 cases. Both groups were given routine pregnancy health care, based on this, the control group received aerobic walking for 6 times a week, and the experimental group was implemented nonconsecutive aerobic resistance training for 6 times a week. The fasting blood glucose and 2 h postprandial blood glucose levels of the two groups were compared at the time of enrollment, the 4th week, the 8th week and the 12th week of intervention, childbirth outcome was also compared between two groups.Results:At the 8th week and the 12th week of intervention, the levels of fasting blood glucose were (5.15 ± 0.48), (4.85 ± 0.37) mmol/L in the experimental group, lower than (5.36 ± 0.46), (5.18 ± 0.48) mmol/L in the control group; at the 4th, 8th and 12th week of intervention, 2 h postprandial blood glucose levels were (6.45 ± 0.52), (6.34 ± 0.44), (6.21 ± 0.40) mmol/L in the experimental group, lower than (6.73 ± 0.56), (6.74 ± 0.48), (6.49 ± 0.45) mmol/L in the control group, the difference was statistically significant ( t values were 2.19-4.30, P<0.05). The natural delivery rate in the experimental group was 85.7% (42/49), which was higher than 69.2% (36/52) in the control group; the incidence of perineal injury and respiratory distress were 12.2% (6/49) and 2.0% (1/49) in the experimental group, lower than 28.9% (15/52) and 15.4% (8/52) in the control group, the difference was statistically significant ( χ2 = 3.89, 4.22, P<0.05). Conclusions:Nonconsecutive aerobic resistance training can effectively control blood glucose, increase the natutal delivery rate and improve delivery outcomes of women with gestational diabetes mellitus.

Effect of Bufei Yishen Prescription on Airway Mucus Hypersecretion and Notch3 and HES1 Expression in Lung Tissues of Rats with Chronic Obstructive Pulmonary Disease / 中国实验方剂学杂志

ObjectiveTo observe the effects of Bufei Yishen prescription on airway mucus hypersecretion and Notch signaling pathway related protein Notch3 and enhancer of split homologue 1 （HES1） in rats with chronic obstructive pulmonary disease （COPD） and to explore its action mechanism. MethodForty-eight SD rats were randomly divided into the control group， model group， Bufei Yishen prescription group， and aminophylline （APL） group，with 12 rats in each group. The stable COPD rat model was established via cigarette smoking exposure combined with Klebsiella bacterial infection for 12 weeks， and the corresponding drugs （3.7 g·kg-1·d-1 Bufei Yishen prescription and 54 mg·kg-1·d-1 APL） were administered by gavage during the next eight weeks. After the last administration at week 20， the lung tissue was sampled for observing the pathological changes and the rat lung function was detected. The tumor necrosis factor-α （TNF-α）， interleukin-6 （IL-6）， and mucoprotein 5AC （MUC5AC） in bronchial alveolar lavage fluid and the mRNA and protein expression levels of Notch3， HES1， and MUC5AC in lung tissues were assayed. ResultCompared with the control group， the model group exhibited significantly weakened pulmonary function （P<0.05，P<0.01）， reduced average number of alveoli （P<0.01）， elevated mean linear intercept （P<0.01）， and up-regulated TNF-α， IL-6， and MUC5AC in bronchial alveolar lavage fluid and Notch3， HES1， and MUC5AC mRNA and protein expression in lung tissue （P<0.05，P<0.01）. Compared with the model group， Bufei Yishen prescription and APL remarkably enhanced pulmonary function， alleviated its pathological injury （P<0.05，P<0.01）， and down-regulated TNF-α， IL-6， and MUC5AC in bronchial alveolar lavage fluid and the mRNA and protein expression levels of Notch3， HES1， and MUC5AC in lung tissues （P<0.05，P<0.01）. ConclusionThe mechanism of Bufei Yishen prescription in inhibiting airway mucus hypersecretion of COPD rats was related to its regulation of Notch3 and HES1.

Rational synthesis of CoFeP@nickel-manganese sulfide core-shell nanoarrays for hybrid supercapacitors.

Transition metal phosphide electrodes, particularly those with unique morphologies and micro-/nanostructures, have demonstrated desirable capabilities for hybrid supercapacitor applications by virtue of their superior electrical conductivity and high electrochemical activity. Here, three-dimensional hierarchical CoFeP@nickel-manganese sulfide nanoarrays were in situ constructed on a flexible carbon cloth via a hydrothermal method, a phosphorization process, followed by an electrodeposition approach. In this smart nanoarchitecture, CoFeP nanorods grown on carbon cloth act as the conductive core for rapid electron transfer, while the nickel-manganese sulfide nanosheets decorated on the surface of CoFeP serve as the shell for efficient ion diffusion, forming a stable core-shell heterostructure with enhanced electrical conductivity. Benefiting from the synergy of the two components and the generation of a heterointerface with a modified electronic structure, The CoFeP@nickel-manganese sulfide electrodes deliver a high capacity of 260.7 mA h g-1 at 1 A g-1, excellent rate capability, and good cycling stability. More importantly, an aqueous hybrid supercapacitor based on CoFeP@nickel-manganese sulfide as a positive electrode and a lotus pollen-derived hierarchical porous carbon as a negative electrode is constructed to display a maximum energy density of 60.1 W h kg-1 at 371.8 W kg-1 and a good cycling stability of 85.7% capacitance retention after 10 000 cycles.