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J Asian Nat Prod Res ; 25(5): 484-496, 2023 May.
Article in English | MEDLINE | ID: mdl-35866240

ABSTRACT

Metabolic disorder is highly related to obesity, insulin resistance, hypertension, and hyperlipidemia. The present study found that astragaloside IV (ASI) attenuated metabolic disorder related symptoms and modulated hepatic lipid metabolism associated gene mRNA expression in db/db mice. ASI inhibited rosiglitazone-induced adipocyte differentiation of 3T3-L1 cells, and lipid accumulation in palmitic acid (PA)-induced HepG2 cells with down-regulated mRNA expression of lipogenesis-related genes. In addition, it was predicted to bind to the ligand binding domain (LBD) of PPARγ and inhibit its transactivity. Collectively, our study suggested that ASI improves lipid metabolism in obese mice probably through suppressing PPARγ activity.


Subject(s)
Obesity , PPAR gamma , Mice , Animals , PPAR gamma/genetics , PPAR gamma/metabolism , Mice, Obese , Obesity/drug therapy , Obesity/metabolism , RNA, Messenger , 3T3-L1 Cells , Mice, Inbred C57BL
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