A latent class analysis of hopelessness in relation to depression and trauma during the COVID-19 pandemic in China.

BACKGROUND: Hopelessness is closely related to depression, trauma, and some organic diseases. Yet our understanding of the heterogeneity of hopelessness is limited. This study aimed to explore the heterogeneity of hopelessness, how it corresponds to the severity of depression, and the effect of traumatic experiences on it during COVID-19. METHOD: The current study measures 28,360 Chinese college students (67.4 % of women) with the Beck Hopelessness Scale (BHS), Trauma Experience Questionnaire, and Patient Health Questionnaire-9 (PHQ-9). The method of latent class analysis (LCA) was used to identify different sub-groups of hopelessness with differences in emotion, motivation, and cognition. Logistic regression and analysis of variance were used to determine the characteristics of different sub-groups. RESULTS: Three latent classes were identified: Negative affective cognition class (C1, N = 5940, 20.9 %), Negative thought cognition class (C2, N = 1358, 4.8 %), and Low hopelessness class (C3, N = 21,062, 74.3 %). Gender, only child or not, birthplace, family economic status, and grade are predictors of the latent category of hopelessness. There are significant differences in depression among different latent classes, and C1 > C2 > C3 (p < 0.001). Traumatic experience is a risk factor for the hopeless latent classes (OR > 1, P < 0.001). LIMITATIONS: Research findings may not be applied to other populations and rely on subjective reports. Ignore the effects of other protective and risk factors. Lack of longitudinal research, unable to explore causality. CONCLUSIONS: The current study provides evidence for the heterogeneity of hopelessness and informs targeted interventions for mental health problems (hopelessness) in college students.

Efficacy of adenosylmethionine combined with Si Mo Tang in treatment of neonatal jaundice.

OBJECTIVE: To investigate the efficacy of S-adenosylmethionine (SAM-e) combined with Si Mo Tang in the treatment of neonatal jaundice and its effect on liver function, cardiac enzymes, immune function, serum transferrin (TRF) and C-reactive protein (CRP) levels. METHODS: The clinical data of 149 infants with neonatal jaundice were collected retrospectively. The infants were grouped according to the treatment methods. All neonates were treated with blue light phototherapy. Besides, group A was treated with SAM-e, group B was treated with Si Mo Tang, and group C was treated with SAM-e combined with Si Mo Tang. The treatment efficacy, serum bilirubin level, neonatal behavioral neurological assessment (NBNA) score, liver function, cardiac enzymes, immune function, serum TRF and CRP level were compared among the three groups before and after treatment. RESULTS: The total effective rate of treatment in group C was 96.00%, which was higher than group A (73.47%) and group B (78.00%) (P < 0.05), but no significant difference was observed between groups A and B (P > 0.05). Compared with groups A and B, group C had higher NBNA scores, lower serum bilirubin levels, and lower serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), creatine kinase (CK) and creatine kinase-MB (CK-MB) levels (all P < 0.05); however, there was no statistical differences in NBNA scores, serum bilirubin levels, serum AST and ALT, LDH, CK and CK-MB levels between group A and group B (all P > 0.05). Compared with groups A and B, group C showed higher CD4+, CD4+/CD8+, TRF levels and lower serum CRP levels (P < 0.05), while there was no statistical differences in CD4+, CD4+/CD8+, CD8+, TRF levels and serum CRP levels between group A and group B (all P > 0.05). CONCLUSION: SAM-e combined with Si Mo Tang promoted the regression of jaundice, improved liver function, neurodevelopmental conditions and the myocardial enzyme spectrum, reduced the level of inflammation, and improved the immunity of newborns with neonatal jaundice.

Hypoglycemia and Dandy-Walker variant in a Kabuki syndrome patient: a case report.

BACKGROUND: Kabuki syndrome (KS) is a rare congenital condition with cardinal manifestations of typical facial features, developmental delays, skeletal anomalies, abnormal dermatoglyphic presentations, and mild to moderate intellectual disability. Pathogenic variants in two epigenetic modifier genes, KMT2D and KDM6A, are responsible for KS1 and KS2, respectively. CASE PRESENTATION: A Chinese girl had persistent neonatal hypoglycemia and Dandy-Walker variant. Whole-exome sequencing identified a novel single nucleotide deletion in KMT2D (NM_003482.3 c.12165del p.(Glu4056Serfs*10)) that caused frameshift and premature termination. The mutation was de novo. According to the American College of Medical Genetics and Genomics (ACMG) guidelines, this variant is considered pathogenic. The patient was diagnosed with KS by molecular testing. CONCLUSION: A single novel mutation in KMT2D was identified in a KS patients with hypoglycemia and Dandy-Walker variant in the neonatal stage. A molecular test was conducted to diagnose KS at an early stage.

[Value of Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Evaluating Diffuse Tumor Infiltration of Bone Marrow in Patients with Acute Leukemia].

OBJECTIVE: To analyze the value of dynamic contrast-enhanced magnetic resonance imaging (CEMRI) for evaluating diffuse tumor infiltration of bone marrow in patients with acute leukemia (AL). METHODS: From January 2010 to February 2016, 80 AL patients admitted in our hospital were chosen as AL patient group, 100 healthy people were chosen as control group, and all subjects were diagnosed with MRI and CEMRI. The Emax and Slope of ilium and vertebra lumbalis were compared between AI patient and control groups. The relation of Emax and Slope with protocells % was analyzed. RESULTS: The Emax and Slope of AL patients were significantly higher than those of control group (P<0.05). After treatment, the Emax and Slope of CR/PR patients decreased significantly (P<0.05). Multiple regression analysis showed that the protocells %=-0.5632+0.0540 Emax+0.0056 Slope. The Emax and Slope of AL patients had significant correlation with Protocells %(P<0.05). CONCLUSION: The results of CEMRI relate with pathological examination and treatment effect.

Height and kidney cancer risk: a meta-analysis of prospective studies.

PURPOSE: The aim of this study was to perform a meta-analysis to summarize the available evidence from prospective studies on the association between height and kidney cancer risk. METHODS: Relevant studies were identified through the MEDLINE and EMBASE databases up to July 2014, as well as through the references from the retrieved articles. Relative risks (RRs) from individual studies were pooled by using a random-effects model. RESULTS: A total of fourteen prospective studies of adult height and kidney cancer risk with 18,766 cases were included in the meta-analysis. Overall, per 10-cm increase in height was associated with an increased risk of kidney cancer (RR 1.23; 95 % confidence interval 1.18-1.28, I(2) = 11.8 %). Subgroup analysis showed a basically consistent result with the overall analysis. There was no evidence of publication bias. CONCLUSIONS: High adult height was positively associated with the risk of kidney cancer in both men and women in this meta-analysis. Future prospective studies are needed to determine the generalizability of these findings to non-Caucasians.

Citrus fruit intake and bladder cancer risk: a meta-analysis of observational studies.

Epidemiological studies have investigated the association between citrus fruit and bladder cancer risk; however, the results are inconsistent. To assess these issues, we conducted a meta-analysis of currently available studies. We identified relevant articles by searching the MEDLINE and EMBASE databases. We calculated the summary relative risk (RR) with 95% confidence interval (95% CI) using a random effect model. We included eight case-control studies and six cohort studies in the meta-analysis. There was a significant inverse association between citrus fruit intake and bladder cancer risk in all pooled studies (RR: 0.85; 95% CI, 0.76-0.94) and case-control studies (RR: 0.77; 95% CI, 0.64-0.92), but not in the cohort studies (RR: 0.96; 95% CI, 0.87-1.07). Our results suggest that citrus fruit intake is related to decreased bladder cancer risk. Subsequent well-designed, large prospective studies are needed to obtain better understanding of this relationship.