ABSTRACT
Monoacylglycerol lipase (MGL) is a serine hydrolase that plays a major role in the degradation of endogenous cannabinoid 2-arachidonoylglycerol. The role of MGL in some cancer cells has been confirmed, where inhibition of the MGL activity shows inhibition on cell proliferation. This makes MGL a promising drug target for the treatment of cancer. Recently, the development of covalent inhibitors of MGL has developed rapidly. These drugs have strong covalent binding ability, high affinity, long duration, low dose and low risk of drug resistance, so they have received increasing attention. This article introduces the structure and function of MGL, the characteristics, mechanisms and progress of covalent MGL inhibitors, providing reference for the development of novel covalent small molecule inhibitors of MGL.
Subject(s)
Endocannabinoids , Monoacylglycerol Lipases , Monoacylglycerol Lipases/chemistry , Monoacylglycerol Lipases/metabolism , Endocannabinoids/metabolismABSTRACT
PURPOSE: To investigate the influence of maxillary protraction combined with maxillary molar distalization appliance therapy on skeletal Class III cross bite malocclusion. METHODS: 60 patients with cross bite and crowding malocclusion were treated with maxillary protraction combined with maxillary molar distalization appliance. The arch length was analyzed before wearing appliance (T1), after debonding appliance(T2), and one year after debonding appliance(T3). SPSS10.0 software package was used for ANOVA. RESULTS: Before therapy, the maxillary arch length was not enough with arch length discrepancy. After active treatment, the device had extended the length of the upper dental arch significantly to relieve crowding and change the cross bite. Esthetics were greatly enhanced. CONCLUSIONS: Maxillary protraction combined with maxillary molar distalization appliance therapy change the maxillary arch length. However, further study is necessary to understand the long-term clinical effect.
