1.
Nat Prod Res
; 37(9): 1491-1497, 2023 May.
Article
in English
| MEDLINE
| ID: mdl-34986726
ABSTRACT
Chemical investigation of the edible mushroom Sarcomyxa edulis led to the isolation of one new highly degraded sterol (1), and one new ß-carboline alkaloid (2), along with nine known compounds (3-11) for the first time from this mushroom. The structures of new compounds were elucidated using HR-ESI-MS data and NMR spectroscopy. In addition, anti-inflammatory activity of new compounds was evaluated against lipopolysaccharide-induced NO production in RAW 264.7 macrophages. Compound 2 exhibited a good anti-inflammatory activity with IC50 value of 9.88 ± 0.48 µM, and compound 1 exhibited a weak inhibitory effect with IC50 value of 71.36 ± 5.11 µM.
Subject(s)
Agaricales , Alkaloids , Animals , Mice , Agaricales/chemistry , Macrophages , Alkaloids/pharmacology , Anti-Inflammatory Agents/pharmacology , Anti-Inflammatory Agents/chemistry , RAW 264.7 Cells , Molecular Structure
2.
Sheng Li Ke Xue Jin Zhan
; 36(4): 365-8, 2005 Oct.
Article
in Chinese
| MEDLINE
| ID: mdl-16408782