ABSTRACT
A water-soluble compound, sodium formononetin-3'-sulfonate with good lipid-lowering and liver-protection activities was synthesized. It was synthesized by sulfonation reaction, and its structure was characterized by IR, NMR and elemental analyses. The solubility of sodium formononetin-3'-sulfonate in water and n-octanol/water partition coefficient were determined by UV spectrophotometry. The lipid-lowering and liver-protection activities of sodium formononetin-3'-sulfonate were tested by using rat's high fat model induce by feeding with high fat food. The results showed that sodium formononetin-3'-sulfonate not only had favorable water, solubility but also had good lipid-lowering and liver-protection activities.
Subject(s)
Adipose Tissue/drug effects , Hypolipidemic Agents/chemical synthesis , Isoflavones/chemical synthesis , Lipids/blood , Liver/enzymology , Alanine Transaminase/metabolism , Animals , Aspartate Aminotransferases/metabolism , Cholesterol/blood , Cholesterol, HDL/blood , Cholesterol, LDL/blood , Hypolipidemic Agents/chemistry , Hypolipidemic Agents/pharmacology , Isoflavones/chemistry , Isoflavones/pharmacology , Liver/pathology , Male , Molecular Structure , Protective Agents/chemical synthesis , Protective Agents/chemistry , Protective Agents/pharmacology , Rats , Rats, Sprague-Dawley , Solubility , Triglycerides/bloodABSTRACT
The title compound, C(18)H(16)O(4), is composed of a benzopyran-one core with a 4-methoxy-phenyl subsituent in the 3-position and an additional eth-oxy group in the 7-position. The benzopyran-one ring is not coplanar with the benzene ring, the dihedral angle between them being 41.76â (7)°. The meth-oxy and eth-oxy substituents are nearly coplanar with the ring systems to which they are attached. Individual mol-ecules are linked by two kinds of inter-molecular hydrogen bonds into chains containing classical R(2) (2)(8) rings. The chains are further assembled by aromatic F-tape and T-tape stacking inter-actions and additional inter-molecular hydrogen bonding to give a two-dimensional network.
ABSTRACT
In the title compound, [Ni(H2O)6](C17H13O7S)2.8H2O, the NiII atom is located on an inversion centre in the space group P2(1)/c. The [Ni(H2O)6]2+, C17H13O7S- and H2O components form many hydrogen bonds and there are pi-pi stacking interactions between the isoflavone units. The hydrogen bonds, pi-pi stacking interactions and electrostatic interactions between the cation and anions link the components into a three-dimensional structure.
