Compressive Strength of Midfoot Fusion Nail vs Midfoot Fusion Bolt and Role of Subtalar Fusion in Midfoot Charcot Fixation Model.

BACKGROUND: Operative management of midfoot Charcot arthropathy often involves an extended midfoot arthrodesis with intramedullary bolts for fixation, a method called "beaming." Recently intramedullary nails have been introduced for the same indication, presumably providing stronger fixation. This study compares midfoot fusion nails to bolts with regard to stiffness and compressive ability. Additionally, we assessed how the addition of a subtalar fusion affects the construct. METHODS: Medial column fusions were performed on 10 matched cadaver foot specimens with either a midfoot fusion nail or bolt. Specimens underwent cyclical compression loading, and displacement was measured. Separately, compressive forces produced were compared between the 2 fixation constructs using a synthetic bone block model. Lastly, another 10 matched specimens with midfoot fusion nails were evaluated with or without subtalar fusions. RESULTS: No differences in stiffness were found in comparing matched specimens between nail vs bolt or comparing nail only without subtalar fusion (STF) vs nail with STF. The compressive force produced by the nail specimens was significantly and substantially greater than the bolted specimens (751.7 vs 139.0 N, P = .01). The accumulated height drop at the midfoot after cycling was 0.5 mm more in the nail group than in the bolt group (1.72 vs 1.22 mm, P = .008). The nail with STF group had greater initial height drop at the midfoot than the nail-only group (0.68 vs 0.34 mm, P = .035) with similar initial height drop at the ankle. However, there were no differences in strength among the matched pairs of midfoot nail-only vs midfoot nail with STF as measured by displacement after fatigue or maximum force at load to failure. CONCLUSION: The overall cadaveric comparisons between matched pairs of nails vs bolts, and nail-only vs nail with STF, did not provide noteworthy differences between the groups with regard to strength or stiffness. However, the compressive force of the midfoot fusion nail was far superior to the bolt in a synthetic bone model. These data provide valuable insight comparing implants used in Charcot midfoot arthrodesis.

Weight-adaptive joint mixed-precision quantization and pruning for neural network-based equalization in short-reach direct detection links.

Neural network (NN)-based equalizers have been widely applied for dealing with nonlinear impairments in intensity-modulated direct detection (IM/DD) systems due to their excellent performance. However, the computational complexity (CC) is a major concern that limits the real-time application of NN-based receivers. In this Letter, we propose, to our knowledge, a novel weight-adaptive joint mixed-precision quantization and pruning approach to reduce the CC of NN-based equalizers, where only integer arithmetic is taken into account instead of floating-point operations. The NN connections are either directly cutoff or represented by a proper number of quantization bits by weight partitioning, leading to a hybrid compressed sparse network that computes much faster and consumes less hardware resources. The proposed approach is verified in a 50-Gb/s 25-km pulse amplitude modulation (PAM)-4 IM/DD link using a directly modulated laser (DML) in the C-band. Compared with the traditional fully connected NN-based equalizer operated with standard floating-point arithmetic, about 80% memory can be saved at a minimum network size without degrading the system performance. Quantization is also shown to be more suitable to over-parameterized NN-based equalizers compared with NNs selected at a minimum size.

The Effect of Lower Limb Alignment on Tibiofemoral Joint Contact Biomechanics after Medial Meniscus Posterior Root Repair: A Finite-Element Analysis.

INTRODUCTION: The purpose of this study was to determine how variations in lower limb alignment affect tibiofemoral joint contact biomechanics in the setting of medial meniscus posterior root tear (MMPRT) and associated root repair. METHODS: A finite-element model of an intact knee joint was developed. Limb alignments ranging from 4° valgus to 8° varus were simulated under a 1,000 N compression load applied to the femoral head. For the intact, MMPRT, and root repair conditions, the peak contact pressure (PCP), total contact area, mean and maximum local contact pressure (LCP) elevation, and total area of LCP elevation of the medial tibiofemoral compartment were quantified. RESULTS: The PCP and total contact area of the medial compartment in the intact knee increased from 2.43 MPa and 361 mm 2 at 4° valgus to 9.09 MPa and 508 mm 2 at 8° of varus. Compared with the intact state, in the MMPRT condition, medial compartment PCP was greater and the total contact area smaller for all alignment conditions. Root repair roughly restored PCPs in the medial compartment; however, this ability was compromised in knees with increasing varus alignment. Specifically, elevations in PCP relative to the intact state increased with increasing varus, as did the total contact area with LCP elevation. After root repair, medial compartment PCP remained elevated above the intact state at all degrees tested, ranging from 0.05 MPa at 4° valgus to 0.27 MPa at 8° of varus, with overall PCP values increasing from 2.48 to 9.09 MPa. For varus alignment greater than 4°, root repair failed to reduce the total contact area with LCP elevation relative to the MMPRT state. DISCUSSION: Greater PCPs and areas of LCP elevation in varus knees may reduce the clinical effectiveness of root repair in delaying or preventing the development of tibiofemoral osteoarthritis.

Mode-division-multiplexing self-homodyne coherent transmission over a weakly coupled few-mode fiber for optical interconnections.

Self-homodyne coherent transmission has recently received extensive investigation as a coherent lite candidate for high-speed short-reach optical networks. In this Letter, we propose a weakly coupled mode-division-multiplexing (MDM) self-homodyne coherent scheme using a multiple-ring-core few-mode fiber, in which one of the modes transmits a self-homodyne local oscillator (LO) and the rest are utilized for carrying signals. Multiple rings of index perturbations in the fiber core are applied to achieve low modal crosstalk, allowing the signals and the remote LO to be transmitted independently. We experimentally demonstrate a 7.2-Tb/s (5.64-Tb/s net rate) self-homodyne coherent transmission with an 800-Gb/s data rate for each of the nine information-bearing modes formatted in 80-GBaud probabilistic constellation-shaped 64-quadrature-amplitude modulation. To the best of our knowledge, this is the first experimental demonstration of an MDM self-homodyne coherent transmission with up to 10 spatial modes. The proposed scheme may pave the way for future high-capacity data center interconnections.

Gradient-descent noise whitening techniques for short-reach IM-DD optical interconnects with severe bandwidth limitation.

Bandwidth limitation in optoelectrical components and the chromatic dispersion-induced power fading phenomenon cause severe inter-symbol interference (ISI) in high-speed intensity modulation and direct detection (IM-DD) optical interconnects. While the equalizer implemented in the receiver's digital signal processing procedure can mitigate ISI, it also inevitably enhances the noise located in the decayed frequency region, known as equalization-enhanced colored noise (EECN). Additionally, the nonlinear impairments of the modulator and photodetector also deteriorate the performance of the IM-DD system, especially for high-order modulation formats. In this work, we propose a gradient-descent noise whitening (GD-NW) algorithm to address EECN and extend it by introducing nonlinear kernels to simultaneously mitigate EECN and nonlinear impairments. The proposed algorithms are compared with conventional counterparts in terms of the achievable baud rate and the receiver optical power sensitivity. As a proof-of-concept experiment, we validate the principles of the proposed algorithms by successfully transmitting 360-GBd on-off-keying (OOK) and 180-GBd 4-level pulse-amplitude-modulation (PAM-4) signals in the back-to-back case under a 62-GHz brick-wall bandwidth limitation. 280-GBd OOK and 150-GBd PAM-4 transmissions are also demonstrated over 1-km standard single-mode fiber with a bit error rate below 7% hard-decision forward error correction aided by the proposed approach.

Biomechanical Assessment of Bicortical Suspension Device Fixation for Proximal Tibiofibular Joint Instability: Single Versus Double Device.

BACKGROUND: Bicortical suspension device (BCSD) fixation treats proximal tibiofibular joint (PTFJ) instability in both the anterolateral and posteromedial directions. However, biomechanical data are lacking as to whether this technique restores the native stability and strength of the joint. PURPOSE: To test (1) if BCSD fixation restores the native stability and strength and (2) if using 2 devices is needed. STUDY DESIGN: Controlled laboratory study. METHODS: Sixteen pairs of fresh-frozen cadaveric specimens were obtained. Six pairs were assigned to the control group and 10 matched pairs assigned for transection to model PTFJ and subsequent BCSD fixation (one specimen with 1-device repair and the other with 2-device repair). Joint stability and strength were assessed by translating the fibular head relative to the fixed tibia either anterolaterally or posteromedially. Control specimens received 20 cycles of 0- to 2.5-mm joint displacement tests (subfailure) and then proceeded to load to failure (5 mm). For the experimental group, cyclic tests were repeated after ligament resection and after fixation. Forces and stiffness at 2.5- and 5-mm displacement were recorded for comparisons of joint strength and stability at subfailure and failure loads, respectively. RESULTS: After repair of anterolateral instability, both the single- and double-device fixations successfully restored near-native states, with no significant differences as compared with the intact group for forces at subfailure load (P = .410) or failure load (P = .397). Regarding posteromedial instability, single-device repair did not restore forces to the near-native state at subfailure load (intact: 92.9 N vs single: 37.4 N; P = .001) or failure load (intact: 170.7 N vs single: 70.4 N; P = .024). However, the double-device repair successfully restored near-native posteromedial forces at both subfailure load (P = .066) and failure load (P = .723). CONCLUSION: For treatment of the most common form of PTFJ instability (anterolateral), this cadaveric study suggests that 1 BCSD is sufficient to restore stability and strength. The current biomechanical results also suggest that 2 devices are needed for restoring PTFJ posteromedial stability and strength. Using 2 devices addresses both types of instability and provides more PTFJ posteromedial stability. CLINICAL RELEVANCE: The results suggest that 1 device should be used for treating anterolateral instability and 2 devices used for posteromedial instability based on the biomechanical study.

Patellofemoral Joint Loading during the Performance of the Wall Squat and Ball Squat with Heel-to-Wall-Distance Variations.

INTRODUCTION: Although bodyweight wall and ball squats are commonly used during patellofemoral rehabilitation, patellofemoral loading while performing these exercises is unknown, which makes it difficult for clinicians to know how to use these exercises in progressing a patient with patellofemoral pathology. Therefore, the purpose was to quantify patellofemoral force and stress between two bodyweight squat variations (ball squat vs wall squat) and between two heel-to-wall-distance (HTWD) variations (long HTWD vs short HTWD). METHODS: Sixteen participants performed a dynamic ball squat and wall squat with long HTWD and short HTWD. Ground reaction force and kinematic data were used to measure resultant knee force and torque from inverse dynamics, whereas electromyographic data were used in a knee muscle model to predict resultant knee force and torque, and subsequently, all these data were inputted into a biomechanical computer optimization model to output patellofemoral joint force and stress at select knee angles. A repeated-measures two- and three-way ANOVA ( P < 0.01) was used for statistical analyses. RESULTS: Collapsed across long HTWD and short HTWD, patellofemoral joint force and stress were greater in ball squat than wall squat at 30° ( P = 0.009), 40° ( P = 0.008), 90° ( P = 0.003), and 100° ( P = 0.005) knee angles during the squat descent, and greater in wall squat than ball squat at 100° ( P < 0.001), 90° ( P < 0.001), 80° ( P = 0.004), and 70° ( P = 0.009) knee angles during squat ascent. Collapsed across ball and wall squats, patellofemoral joint force and stress were greater with a short HTWD than a long HTWD at 100° ( P = 0.007) and 90° ( P = 0.008) knee angles during squat ascent. CONCLUSIONS: Patellofemoral joint loading changed according to both squat type and HTWD variations. These differences occurred in part due to differences in forces the wall or ball exerted on the trunk, including friction forces. Overall, patellofemoral force and stress were greater performing the bodyweight wall squat compared with the bodyweight ball squat. Moreover, squatting with short HTWD produced anterior knee displacement beyond the toes at higher knee angles, resulting in greater patellofemoral force and stress compared with squatting with long HTWD.

The Hybrid Transtibial Technique for Femoral Tunnel Drilling in Anterior Cruciate Ligament Reconstruction: A Finite Element Analysis Model of Graft Bending Angles and Peak Graft Stresses in Comparison With Transtibial and Anteromedial Portal Techniques.

PURPOSE: The purpose of this finite element analysis was to compare femoral tunnel length; anterior cruciate ligament reconstruction graft bending angle; and peak graft stress, contact force, and contact area created by the transtibial, anteromedial portal (AMP), and hybrid transtibial techniques. METHODS: Finite element analysis modeling was used to examine anterior cruciate ligament reconstruction models based on transtibial, AMP, and hybrid transtibial femoral tunnel drilling techniques. An evaluation of femoral tunnel length, graft bending angle, peak graft stress, contact force, and contact area was done in comparison of these techniques. RESULTS: The femoral tunnel created with the hybrid transtibial technique was 45.3 mm, which was 13.3% longer than that achieved with the AMP technique but 15.2% shorter than that with the transtibial technique. The femoral graft bending angle with the hybrid transtibial technique (105°) was less acute than that with the AMP technique (102°), but more acute than that with the transtibial technique (109°). At 11° knee flexion, the hybrid transtibial technique had 22% less femoral contact force, 21% less tibial contact force, 21% less graft tension than the AMP technique. Yet, the hybrid transtibial technique had 41% greater femoral contact force, 39% greater tibial contact force, 33% greater graft tension, and 6% greater graft von Mises stress than the transtibial technique. A similar trend was found for the anterior knee drawer test. At both 6-mm anterior tibial displacement and 11° knee flexion, the hybrid transtibial and AMP techniques had at least 51% more femoral contact area than the transtibial technique. CONCLUSION: This finite element analysis highlights that the hybrid transtibial technique is a true hybrid between the AMP and transtibial techniques for femoral tunnel drilling regarding femoral tunnel length, graft bending angle, and peak graft stress.

Patellofemoral Joint Loading in Forward Lunge With Step Length and Height Variations.

The objective was to assess how patellofemoral loads (joint force and stress) change while lunging with step length and step height variations. Sixteen participants performed a forward lunge using short and long steps at ground level and up to a 10-cm platform. Electromyography, ground reaction force, and 3D motion were captured, and patellofemoral loads were calculated as a function of knee angle. Repeated-measures 2-way analysis of variance (P < .05) was employed. Patellofemoral loads in the lead knee were greater with long step at the beginning of landing (10°-30° knee angle) and the end of pushoff (10°-40°) and greater with short step during the deep knee flexion portion of the lunge (50°-100°). Patellofemoral loads were greater at ground level than 10-cm platform during lunge descent (50°-100°) and lunge ascent (40°-70°). Patellofemoral loads generally increased as knee flexion increased and decreased as knee flexion decreased. To gradually increase patellofemoral loads, perform forward lunge in the following sequence: (1) minimal knee flexion (0°-30°), (2) moderate knee flexion (0°-60°), (3) long step and deep knee flexion (0°-100°) up to a 10-cm platform, and (4) long step and deep knee flexion (0°-100°) at ground level.

Superiorly and transversely orienting the bicortical suspension device provides optimal anterolateral stability to the proximal tibiofibular joint: a finite-element study.

PURPOSE: Instability of the proximal tibiofibular joint (PTFJ) can be treated with bicortical suspension (BCS) fixation. However, the ideal location, orientation, and configuration to apply one or two BCS devices are not clear. METHODS: A finite-element model of the PTFJ was created from a female adult's CT dataset. Anterior and posterior ligaments at the PTFJ were modeled and suppressed to simulate stable and unstable joints. Fifty-six models simulated 56 device placements along guiding tunnel lines that connect eight entry locations on the fibular head to seven exit points on the anteromedial tibia. Doubling device stiffness created 56 more models. Combing any two placements created 1176 double-device configurations which were categorized to be crossed, divergent or parallel. Displacement of the fibular head relative to the fixed tibia under 100 N anterolateral and posteromedial forces was assessed. RESULTS: Different placements had 2.1-27.9 mm translation with 0.7-8.9° internal rotation under anterolateral loading, and 1.8-5.2 mm translation with 6.1-7.9° external rotation under posteromedial loading. More transverse and superior orientations were associated with smaller anterolateral translation; more posterior and superior entry locations were associated with smaller internal rotation. The median (IQR) reductions in anterolateral translation by doubling device stiffness and by adding a second device were 0.8 (IQR 0.5-1.0) and 0.8 (IQR 0-6.1) mm, respectively. The type of double-device configurations had no significant effect on fibular motion. CONCLUSION: Surgeons should drill the guiding tunnel superiorly and transversely to ensure the optimal restoration of the PTFJ anterolateral stability.

Patellofemoral Joint Loading During the Performance of the Forward and Side Lunge with Step Height Variations.

BACKGROUND: Forward and side lunge exercises strengthen hip and thigh musculature, enhance patellofemoral joint stability, and are commonly used during patellofemoral rehabilitation and training for sport. HYPOTHESIS/PURPOSE: The purpose was to quantify, via calculated estimates, patellofemoral force and stress between two lunge type variations (forward lunge versus side lunge) and between two step height variations (ground level versus 10 cm platform). The hypotheses were that patellofemoral force and stress would be greater at all knee angles performing the bodyweight side lunge compared to the bodyweight forward lunge, and greater when performing the forward and side lunge at ground level compared to up a 10cm platform. STUDY DESIGN: Controlled laboratory biomechanics repeated measures, counterbalanced design. METHODS: Sixteen participants performed a forward and side lunge at ground level and up a 10cm platform. Electromyographic, ground reaction force, and kinematic variables were collected and input into a biomechanical optimization model, and patellofemoral joint force and stress were calculated as a function of knee angle during the lunge descent and ascent and assessed with a repeated measures 2-way ANOVA (p<0.05). RESULTS: At 10° (p=0.003) knee angle (0° = full knee extension) during lunge descent and 10° and 30° (p<0.001) knee angles during lunge ascent patellofemoral joint force and stress were greater in forward lunge than side lunge. At 40°(p=0.005), 50°(p=0.002), 60°(p<0.001), 70°(p=0.006), 80°(p=0.005), 90°(p=0.002), and 100°(p<0.001) knee angles during lunge descent and 50°(p=0.002), 60°(p<0.001), 70°(p<0.001), 80°(p<0.001), and 90°(p<0.001) knee angles during lunge ascent patellofemoral joint force and stress were greater in side lunge than forward lunge. At 60°(p=0.009) knee angle during lunge descent and 40°(p=0.008), 50°(p=0.009), and 60°(p=0.007) knee angles during lunge ascent patellofemoral joint force and stress were greater lunging at ground level than up a 10cm platform. CONCLUSIONS: Patellofemoral joint loading changed according to lunge type, step height, and knee angle. Patellofemoral compressive force and stress were greater while lunging at ground level compared to lunging up to a 10 cm platform between 40° - 60° knee angles, and greater while performing the side lunge compared to the forward lunge between 40° - 100° knee angles. LEVEL OF EVIDENCE: II.

Detection of knee wobbling as a screen to identify athletes who may be at high risk for ACL injury.

This study developed a method to detect knee wobbling (KW) at low knee flexion. KW consists of quick uncontrollable medio-lateral knee movements without knee flexion, which may indicate a risk of ACL injury. Ten female athletes were recorded while performing slow, single-leg squats. Using motion capture data, the ratio of the frontal angular velocity to sagittal angular velocity (F/S) was calculated. An 'F/S spike' was defined when the F/S ratio exceeded 100%. The number of F/S spikes was counted before and after low-pass filtering at different cut-off frequencies. Intraclass correlation coefficients for KW and filtered F/S spike were analysed. KWs per squat cycle showed a median (range) of 3 (2-8) times. F/S spikes before and after low-pass filtering at 3-, 6-, 10-, and 15-Hz were 51 (12-108), 2 (0-6), 3 (1-12), 5 (2-21), and 9 (3-33) times, respectively. KWs and F/S spikes on motion capture with 6-Hz, low-pass filtering were well correlated (r = 0 .76). Median percentages of valgus and varus F/S spikes were 71% and 29%, respectively. After 6Hz, low-pass filtering, the number of F/S spikes was strongly correlated with observed KWs. An F/S spike assessment may be used to objectively detect KW, including flexion and varus/valgus angular velocity.

Influence of graft type on sagittal plane knee biomechanics during stair ambulation following anterior cruciate ligament reconstruction.

BACKGROUND: Both graft type and surgical technique for anterior cruciate ligament reconstruction can affect knee biomechanics. Several studies reported the influence of graft type, but few have controlled the surgical technique and fully investigated stair ambulation. This study aimed to compare knee biomechanics during stair ambulation between patients treated with hamstring tendon graft and those treated with patellar tendon graft when anterior medial portal technique was used to drill femoral tunnel. METHODS: Two groups of patients (patellar tendon, n = 18; hamstring tendon, n = 18) at average 12 months after reconstruction surgery were recruited to ascend and descend a customized staircase in a gait lab. Joint kinematics and kinetics were calculated for both operated and contralateral intact limbs based on kinematic analysis and inverse dynamics. The influence of graft type on knee flexion angle and moment was identified using one-way mixed (graft type and limb side) analysis of variance with post-hoc paired t-test. FINDINGS: Significant interaction between graft and limb was found for knee flexion and range of motion. Only the hamstring tendon group had significant kinematic deficits on the operated limb than the contralateral limb during stair ascent and descent. No significant interaction was found for knee flexion moment. Both graft groups had significant deficits in peak knee flexion moment on the operated side during stair ascent and descent. INTERPRETATION: While the choice of graft type does not affect the restoration of knee dynamic loading, patellar tendon graft better restores knee flexion-extension kinematics during stair ambulation.

Q-switched-like soliton bunches and noise-like pulses generation in a partially mode-locked fiber laser.

We report an intermediate regime between c.w. emission and noise-like pulses (NLPs) regime in an Er-doped partially mode-locked fiber laser with nonlinear polarization rotation. In this regime, the soliton bunches stochastically turn up from a quasi-cw background in the Q-switched-like envelope. The soliton bunches normally last for tens or hundreds of intracavity round-trips. When the soliton bunches vanish, typical NLPs chains are generated sporadically at location where the soliton bunches collapses. These results would be helpful to understand the generation and property of the NLPs regime.

Intermodal interferometer based on a fluid-filled two-mode photonic crystal fiber for sensing applications.

A fluid-filled two-mode photonic crystal fiber (PCF)-based intermodal interferometer and its sensing characteristics are demonstrated and investigated. The interferometer works from the interference between LP(01) and LP(11) core modes of the fluid-filled PCF. Solutions to enhance the temperature sensitivity of the interferometer are also discussed. Via choosing a higher fluid-filled length ratio of PCF, a sensitivity of more than -340 pm/°C at 1480 nm is achieved, which is the highest value for a PCF intermodal interferometer-based sensor, to our best knowledge. Furthermore, there exist significant differences in temperature and strain sensitivity for two different interference dips, thus the interferometer can be used as a dual-parameter sensor with a compact structure through matrix demodulation.