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1.
Macromol Biosci ; 16(5): 774-83, 2016 05.
Article in English | MEDLINE | ID: mdl-26833548

ABSTRACT

Biodegradable self-assembled polymeric nanoparticles (NPs) composed of poly(6-O-methacryloyl-D-galactopyranose)-b-poly(L-lactide)-b-poly(6-O-methacryloyl-D-galactopyranose) (PMAGP-b-PLA-b-PMAGP) are prepared as carriers for the hydrophobic anticancer drug paclitaxel (PTX), to achieve target delivery to hepatoma cells. PTX can be encapsulated by the NPs with various molar ratios of L-lactide (LA) and 6-O-methacryloyl-D-galactopyranose (MAGP) during the process of self-assembly, and the resulting NPs exhibit high drug loading efficacy and substantial stability in aqueous solution. The size, size distribution, and morphology of the NPs are characterized using a Zetasizer Nano ZS and transmission electron microscopy. The hemolysis assay and cell cytotoxicity assay indicate that the polymeric NPs are biocompatible and non-toxic. The cellular uptake assay demonstrates that the galactose-containing NPs can be selectively recognized and subsequently accumulate in HepG2 cells. All of these results demonstrate that galactose-containing polymeric NPs are potential carriers for hepatoma-targeted drug delivery and liver cancer therapy in clinical medicine.


Subject(s)
Drug Delivery Systems , Liver Neoplasms/drug therapy , Nanoparticles/administration & dosage , Paclitaxel/administration & dosage , Galactose/chemistry , Hep G2 Cells , Humans , Nanoparticles/chemistry , Paclitaxel/chemistry , Polymers/administration & dosage , Polymers/chemistry , Surface-Active Agents/administration & dosage , Surface-Active Agents/chemistry
2.
ACS Appl Mater Interfaces ; 4(2): 665-71, 2012 Feb.
Article in English | MEDLINE | ID: mdl-22264080

ABSTRACT

The paper describes for the first time the successful synthesis of Fe(2)O(3)/TiO(2) tube-like nanostructures, in which TiO(2) shell is of quasi-single crystalline characteristic and its thickness can be controlled through adjusting the added amount of aqueous Ti(SO(4))(2) solution. The characterization of samples obtained at different stages using transmission electron microscope indicates that the outer TiO(2) shell is changed gradually from amorphous and polycrystalline phase into quasi-single crystal under thermal actions through the Ostwald ripening process, accompanying the corrosion of the central parts of Fe(2)O(3) nanorods, and the formation of small particles separating each other, leading to the special core/shell nanorods. Furthermore, Fe(2)O(3)/TiO(2) tube-like nanostructures can be transformed into Fe(2)TiO(5) nanostructures after they are thermally treated at higher temperatures. Those nanostructures exhibit enhanced ethanol sensing properties with respect to the monocomponent. Our results imply that not only hollow nanostructures, but also a novel type of nanostructures can be fabricated by the present method for nanodevices.


Subject(s)
Ferric Compounds/chemistry , Nanostructures/chemistry , Titanium/chemistry , Gases/analysis , Nanostructures/ultrastructure , Temperature , Water/chemistry
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