ABSTRACT
One new species of the genus Conostigmus Dahlbom, 1858, Conostigmus xui Cui and Wang sp. nov., from China is described. A key to the known species of Conostigmus from China is provided.
Subject(s)
Hymenoptera , Animals , ChinaABSTRACT
Tissue analysis by Fourier transform infrared (FTIR) imaging can determine the biodistribution of molecules, without pre-analytical modification. We aimed to study the infrared spectroscopic changes of α-helical proteins at post-traumatic epileptic (PTE) foci by FTIR. FITR mapping was applied to detect α-helical proteins in rat brain tissue samples with post-traumatic epilepsy. Histological examination of brain sections showed that the rat model of PTE was successfully established. At the PTE foci, high α-helical absorption regions were evident, where the color difference and absorption were significantly different from those in the low-absorption regions. This provided a distinctive and characteristic pattern at the site of lesions. The use of FTIR imaging means that it is possible to measure the molecular structural changes resulting from PTE pathologies in tissues, providing a novel adjunct to conventional pathological diagnostic techniques.
Subject(s)
Brain/metabolism , Brain/pathology , Epilepsy, Post-Traumatic/pathology , Protein Conformation, alpha-Helical , Proteins/metabolism , Animals , Proteins/chemistry , Rats , Rats, Sprague-Dawley , Spectroscopy, Fourier Transform Infrared , Tissue DistributionABSTRACT
MicroRNAs (miRNAs) have been identified as potential biomarkers for endometrial carcinoma (EC) diagnosis, prognosis and therapy. The purpose of the present study was to investigate the detailed role and molecular mechanism of miR-195 in EC metastasis. qRT-PCR assay was performed to assess the expression of miR-195 and SRY-related high-mobility group box 4 (SOX4) mRNA in EC tissues and cells. The levels of N-cadherin, Vimentin, E-cadherin and SOX4 protein were determined by western blot. SOX4 protein expression in EC tissues was also determined by Immunohistochemistry (IHC) experiment. Transwell assay was used to analyze cell migration and invasion abilities. Dual-luciferase reporter assay and RNA Immunoprecipitation (RIP) assay were performed to confirm the targeted interaction between miR-195 and SOX4. Our data supported that miR-195 was downregulated and SOX4 was upregulated in EC tissues and cell lines. Upregulation of miR-195 inhibited migration, invasion and epithelial-mesenchymal transition (EMT) of EC cells. Moreover, SOX4 was a direct target of miR-195. MiR-195 overexpression-mediated anti-migration, anti-invasion and anti-EMT effects were antagonized by SOX4 restoration in EC cells. In conclusion, our study suggested that miR-195 inhibited the migration, invasion and epithelial mesenchymal transition (EMT) of EC cells at least partly by targeting SOX4. Our study provided a novel underlying mechanism for EC metastasis and a promising therapeutic target for EC management.
Subject(s)
Endometrial Neoplasms/genetics , Epithelial-Mesenchymal Transition/genetics , MicroRNAs/genetics , SOXC Transcription Factors/genetics , Aged , Cell Line, Tumor , Cell Movement/genetics , Cell Proliferation/genetics , Endometrial Neoplasms/pathology , Female , Gene Expression Regulation, Neoplastic/genetics , Humans , Middle Aged , Neoplasm Invasiveness/genetics , Neoplasm Invasiveness/pathology , RNA, Messenger/geneticsABSTRACT
A new species of the genus Cicadatra Kolenati, 1857, C. hei sp. nov., from Sichuan Province, China is described. A key to the species of Cicadatra from China is provided. Morphological characters for 9 taxa of the tribe Cicadatrini and for 3 outgroup taxa are examined to present the first phylogenetic reconstruction within the Cicadatrini. The monophyly of Cicadatrini is supported, and Cicadatrini is more allied to the outgroup Cicadetta of the subfamily Cicadettinae (= Tibicininae auct.) from TNT and WinClada analyses. The systematic status of the tribe Cicadatrini is discussed. The genus Cicadalna Boulard, 2006 is recognized to be a junior synonym of Emathia Stål, 1866, and Cicadalna takensis Boulard, 2006 is transferred from Cicadalna to Emathia to become Emathia takensis (Boulard, 2006) comb. nov.
Subject(s)
Hemiptera , Animal Distribution , Animals , China , Humans , PhylogenyABSTRACT
Primary carcinoma of the renal calyx is extremely rare. The present study reported nephron sparing endoscopic treatment for primary carcinoma of the renal calyx. An 81-year-old female presented with a 1-year history of intermittent painless gross hematuria. Computed tomography and X-ray of the urinary tract were unable to definitively identify any lesion. Flexible ureteroscopic examination revealed a tumor with epicenter in the lower calyx of the right kidney, with additional involvement around the calyx. Biopsies were obtained and pathology revealed low-grade urothelial carcinoma. Considering additional co-morbidities, the patient elected to undergo endoscopic management with thulium laser. The present report described the feasibility of flexible ureteroscopic thulium laser resection for the treatment of renal calyx carcinoma.
ABSTRACT
Malignant mesothelioma is a rare type of cancer, most commonly associated with exposure to asbestos. Mesothelioma of the peritoneum, the membrane lining the abdominal cavity, is extremely rare. The current study reports the case of a 60-year-old female who presented with intestinal fistula, recurrent incisional hernia and abdominal infection, with no history of asbestos exposure, and was diagnosed with clear cell MPM. Computed tomography scans of the abdomen revealed extensive small bowel adhesions and massive peritoneal effusion. Histological examination of biopsy specimens indicated a diagnosis of malignant peritoneal mesothelioma with clear cell morphology. A laparotomy was performed, with subsequent resection of the bowel with fistula. Follow-up examination performed at 1-year post-surgery revealed that the patient was alive and in generally good health.
