[Expression level and clinical significance of CD44 and CD33 in 77 patients with benign lymphoadenosis of oral mucosa].

PURPOSE: To investigate the expression and clinical significance of CD44 and CD33 in benign lymphoadenosis of oral mucosa(BLOM). METHODS: From January 2017 to March 2020, seventy-seven BLOM wax blocks from the Department of Pathology of Qingdao Traditional Chinese Medicine Hospital were selected as the experimental group, and 63 cases of normal oral mucosal tissue wax blocks during the same period were selected as the control group. Immunohistochemical method was used to detect the positive expression of CD44 and CD33 in the two groups.Spearman correlation analysis was used to analyze the correlation between the positive expression of CD33 and the positive expression of CD44 in the diseased tissues of BLOM patients.The general information about patients were collected.The relationship between the expression of CD33 and CD44 in the diseased tissues of BLOM patients and the clinicopathological characteristics of BLOM patients were analyzed. SPSS 21.0 software package was used for statistical analysis of the data. RESULTS: The positive expression rates of CD33 in the control group and the experimental group were 95.24% and 63.64%, respectively, and the difference was statistically significant(P＜0.05). The positive expression rates of CD44 in the control group and the experimental group were 93.65% and 67.53%, respectively, and the difference was statistically significant(P＜0.05). The results of Spearman correlation analysis showed that the positive expression of CD33 in the diseased tissues of BLOM patients was positively correlated with the positive expression of CD44 (r=0.834, P=0.002). The expression of CD33 and CD44 in the diseased tissues of patients with BLOM were related to clinical type, degree of inflammation, presence or absence of lymphoid follicles, and lymphocyte infiltration(P＜0.05), but not related to age, gender, course of disease, location, and epithelial surface keratinization(P＞0.05). CONCLUSIONS: The positive expression rate of CD33 and CD44 in the BLOM tissues decreased, which was closely related to the clinical type, degree of inflammation, presence or absence of lymphoid follicles, and lymphocyte infiltration.

[Relationship between dental implant mucosa and dental implant papilla levels and peri-implant soft tissue stability].

PURPOSE: To investigate the relationship between dental implant mucosa (DIM) and dental implant papilla (DIP) levels and peri-implant soft tissue stability. METHODS: A total of 86 patients with tooth implant in Qingdao Haici Hospital from January 2015 to January 2019 were enrolled, the patients were followed up from initial treatment till December 2020. Various indexes were recorded at the implantation moment(T0), 4 weeks(T1), 2 years(T2) after implantation and end of follow up (T3), including marginal bone loss levels (MBLs), mid-buccal mucosal levels (MBMLs), modified sulcus bleeding index(mSBI), modified bleeding index(mBI) and implant stability quotient (ISQ). Then the correlation of those indexes was analyzed. SPSS 23.0 software package was used to analyze the data. RESULTS: The follow-up period was 1.0-5.2 years, with an average of (4.79±0.34) years; two cases were lost to follow up, and finally 84 cases (95 implants) were included. Compared with indexes at T0, mSBI, mPLI, mBI, the level of distal bone adjacent to the tooth contact point, and the middle bone level adjacent to the tooth contact point at T1, T2, and T3 decreased significantly(P＜0.05), and DIP height increased significantly; PD, MBLs and MBMLs at T0, T1, T2, and T3 showed no significant difference(P＞0.05). The level of distal bone adjacent to the tooth contact point, and the middle bone level adjacent to the tooth contact point had an impact on DIP(P＜0.05). There were 49 cases with papillae gain in height and 46 cases with papilla that lost height. ISQ of gain height group and loss height group was relatively high at T0(P＜0.05). Compared with T2, there was a decrease in ISQ in both groups at T1(P＜0.05). ISQ of gain height group was significantly higher than that of loss height group at T1 and T2 (P＜0.05). CONCLUSIONS: There is a dependent correction between dental implant mucosa and dental implant papilla levels, and the stability of peri-implant soft tissues depends on keratinized tissue height and DIP height.