Usability of curved keyboard design on the large smartphone: An empirical study.

The curved design is ubiquitous, with a vast user base due to its similarity with in shape to human physiological structure. The curved QWERTY keyboard layout was proposed for one-handed usage on smartphones with ambiguous effects. This study evaluated whether the curved QWERTY could optimize the user experience and input performance on large smartphones better than the traditional straight QWERTY layout. Eight measurements were used to evaluate the usability of each design, six suggesting curved QWERTY failed to achieve outstanding typing performance or subjective user experience, while the other two indicators showed that curved QWERTY had advantages in touch dispersion and touching offset, indicating the possible higher usability it could reach. The results also investigated the potential application of curved designs and provided insights into the optimization methods.

Development and validation of the geriatric trauma frailty index for geriatric trauma patients based on electronic hospital records.

BACKGROUND: Globally, geriatric patients are the dominant population requiring global medical care. We established a frailty index for geriatric trauma patients by retrospectively analysing electronic hospital records to identify patients with frailty characteristics and poor prognostic outcomes. METHOD: Data were obtained from 2016 US National Emergency Department Sample and Shanghai Trauma Emergency Medical Association (2015-18). Overall, 141,267 hospitalised geriatric trauma patients (age ≥ 65 years) were included. We used a three-step method to construct geriatric trauma frailty index (GTFI) based on the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision diagnostic codes. Systematic cluster analysis was used. The accuracy of GTFI was verified in national validation cohort, and its applicability to Chinese patients was assessed in local validation cohort. RESULTS: In development cohort (n = 28,179), frail patients had longer lengths of stay and higher Charlson co-morbidity index than non-frail patients (18.2 ± 12.4 days, 5.59 ± 2.0 versus 5.3 ± 5.3 days, 5.33 ± 1.8, respectively). In national validation cohort (n = 113,089), frail patients had longer lengths of stay (8.5 ± 8.8 days versus 4.5 ± 3.1 days) and higher in-hospital mortality than non-frail patients (2,795, 11.69% versus 589, 0.66%). Areas under the curves for GTFI for length of stay (>14 days) and in-hospital mortality were 0.848 (0.841, 0.854) and 0.885 (0.880, 0.891) in national validation cohort, and were 0.791 (0.779, 0.804) and 0.903 (0.885, 0.922) in local validation cohort (n = 14,827). CONCLUSIONS: The GTFI helps hospitals and emergency departments to identify geriatric trauma patients with poor prognostic outcomes, and has been proven to be useful in China.

Psychological Responses of the Patients in Cabin Hospital to the COVID-19 Outbreak: A Comparative Epidemiologic Analysis.

The building of cabin hospitals in Wuhan has been proven to be clinically successful in curing mild-symptom COVID-19 patients shortly after the outbreak of COVID-19 in late 2019. At the same time, the psychological effect of patients being treated in cabin hospitals and the features of the psychological status of the whole society remained ambiguous. This study adopted a self-administrated questionnaire to investigate the stress, depression, and anxiety status of patients in cabin hospitals (n = 212) and healthy participants outside of Hubei province (n = 221) in a population level from February 29 to March 01, 2020. The research measured participants' stress response, depression level, and anxiety level as well as their social support system and their resilience level. Results indicated that in this sudden outbreak of an unknown pandemic, all people (whether or not infected) showed a generally high level of stress, depression, and anxiety, regardless of age, gender, education level, and employment. It also showed that people with a lower level of psychological resilience and social support reported more severe symptoms of depression, anxiety, and stress. Moreover, the research also found a positive effect of cabin hospitals on the psychological recovery of COVID-19 patients. Stress response of patients increased after entering into cabin hospitals, while after 3-4 weeks' treatment, patients showed a decrease in their depression and anxiety levels. This research advances the understanding of COVID-19 and gives suggestions to optimize the design and the allocation of resources in cabin hospitals and better deal with the unknown pandemics in the future.

Psychological responses among nurses caring for patients with COVID-19: a comparative study in China.

Frontline healthcare nurses devoted themselves to deal with the outbreak of COVID-19, saving many lives. However, they are under incredible unknown psychological pressures with a considerable risk of infection. In this study, a self-administered questionnaire was used to survey 593 frontline nurses in Wuhan City and non-Hubei provinces for psychological responses from March 1 to March 10, 2020. Compared with nurses outside Hubei Province, those working in Wuhan were more likely to feel physically and mentally exhausted. Their probable depression and anxiety were significantly higher than those of nurses outside Hubei province (31.2%, 18.3% vs. 13.8%, 5.9%). Correspondingly, the depressive symptoms were more often reported in the Wuhan group (70.8% vs. 41.4%). Although Wuhan received wishes, concerns, and abundant psychological and material resources from all of the world, the survey-based study found that frontline nurses in Wuhan still had higher depression and anxiety with less social support compared with nurses from non-Hubei provinces. Unexpectedly, only 4.0% of nurses have sought psychological assistance. These findings suggested that the short-term psychological impact of frontline nurses in Wuhan during the COVID-19 outbreak was extremely high compared with nurses outside Hubei Province. This research enlightened the efficient integration of psychological resources, the optimization of the nurse emergency psychological assistance system, and the mental health care of medical staff during the outbreak of epidemics.

Investigating the Performance of Gesture-Based Input for Mid-Air Text Entry in a Virtual Environment: A Comparison of Hand-Up versus Hand-Down Postures.

Although the interaction technology for virtual reality (VR) systems has evolved significantly over the past years, the text input efficiency in the virtual environment is still an ongoing problem. We deployed a word-gesture text entry technology based on gesture recognition in the virtual environment. This study aimed to investigate the performance of the word-gesture text entry technology with different input postures and VR experiences in the virtual environment. The study revealed that the VR experience (how long or how often using VR) had little effect on input performance. The hand-up posture has a better input performance when using word-gesture text entry technology in a virtual environment. In addition, the study found that the perceived exertion to complete the text input with word-gesture text entry technology was relatively high. Furthermore, the typing accuracy and perceived usability for using the hand-up posture were obviously higher than that for the hand-down posture. The hand-up posture also had less task workload than the hand-down posture. This paper supports that the word-gesture text entry technology with hand-up posture has greater application potential than hand-down posture.

Chinese college students' ability to recognize facial expressions based on their meaning-in-life profiles: An eye-tracking study.

OBJECTIVE: People can be categorized into one of four meaning-in-life profiles: High Presence High Search (HPHS), High Presence Low Search (HPLS), Low Presence High Search (LPHS), and Low Presence Low Search (LPLS).The main goal of this study is to provide a theoretical explanation for why Chinese people with different meaning-in-life profiles have different mental health levels than Western people, based on their emotional-cognitive-processing ability. METHOD: We adopted eye-movement analysis and recognition-judgment experimental paradigm concerning absolute-recognition judgment and relative-recognition judgment in our study. Moreover, we applied a multifactor and multilevel mixed-experimental design. We selected 118 participants for the experiments from the 788 Chinese college students who responded. RESULTS: Our results showed that HPHS individuals preferred positive-emotion pictures, LPLS individuals preferred negative-emotion pictures, HPLS individuals preferred positive- and neutral-emotion pictures, and LPHS individuals preferred neutral-emotion pictures. Moreover, HPHS individuals were better at accurately processing facial expression from pictures, while LPLS individuals lacked such ability. The fine-processing ability of HPLS and LPHS individuals was lower than that of HPHS yet higher than that of LPLS individuals. Moreover, the features of HPLS individuals were closer to HPHS, while those of LPHS individuals were closer to LPLS. CONCLUSIONS: Our findings support the hypothesis that meaning-in-life profiles have different immediate processing abilities and preferences regarding facial expression recognition and different emotional-cognitive-processing ability.

An Assessment Method and Toolkit to Evaluate Keyboard Design on Smartphones.

Keyboard input has played an essential role in human-computer interaction with a vast user base, and the keyboard design has always been one of the fundamental objects of studies on smart devices. With the development of screen technology, more precise data and indicators could be collected by smartphones to in-depth evaluate the keyboard design. The enlargement of the phone screen has led to unsatisfactory input experience and finger pain, especially for one-handed input. The input efficiency and comfort have attracted the attention of researchers and designers, and the curved keyboard with size-adjustable buttons, which roughly accorded with the physiological structure of thumbs, was proposed to optimize the one-handed usage on large-screen smartphones. However, its real effects remained ambiguous. Therefore, this protocol demonstrated a general and summarized method to evaluate the effect of curved QWERTY keyboard design on a 5-inch smartphone through a self-developed software with detailed variables, including objective behavioral data, subjective feedback, and the coordinate data of each touchpoint. There is sufficient existing literature on evaluating virtual keyboards; however, only a few of them systematically summarized and took reflection on the evaluation methods and processes. Therefore, this protocol fills in the gap and presents a process and method of the systematic evaluation of keyboard design with available codes for analysis and visualization. It needs no additional or expensive equipment and is easy to conduct and operate. In addition, the protocol also helps to get potential reasons for the disadvantages of the design and enlightens the optimization of designs. In conclusion, this protocol with the open-source resources could not only be an in-class demonstrative experiment to inspire the novice to start their studies but also contributes to improving the user experience and the revenue of input method editor companies.

The impact of frailty on posttraumatic outcomes in older trauma patients: A systematic review and meta-analysis.

BACKGROUND: Frailty is a risk factor for mortality among the elderly. However, evidence from longitudinal studies linking trauma and frailty is fragmented, and a comprehensive analysis of the relationship between frailty and adverse outcomes is lacking. Therefore, we conducted a systematic review and meta-analysis to examine whether frailty is predictive of posttraumatic results including mortality, adverse discharge, complications, and readmission in trauma patients. METHODS: This systematic review was registered with the PROSPERO international prospective register of systematic reviews. Articles in PubMed, Embase, and Web of Science databases from January 1, 1990, to October 31, 2019, were systematically searched. Articles in McDonald et al.'s study (J Trauma Acute Care Surg. 2016;80(5):824-834) and Cubitt et al.'s study (Injury 2019;50(11):1795-1808) were included for studies evaluating the association between frailty and outcomes in trauma patients. Cohort studies, both retrospective and prospective, were included. Study population was patients suffering trauma injuries with an average age of 50 years and older. Multivariate adjusted odds ratios (ORs) were calculated through a random-effects model, and the Newcastle-Ottawa Quality Assessment Scale was used to assess studies. RESULTS: We retrieved 11,313 entries. Thirteen studies including seven prospective and six retrospective cohort studies involving 50,348 patients were included in the meta-analysis. Frailty was a significant predictor of greater than 30-day mortality (OR, 2.41; 95% confidence interval [CI], 1.17-4.95; I = 88.1%), in-hospital and 30-day mortality (OR, 4.05; 95% CI, 2.02-8.11; I = 0%), postoperative complications (OR, 2.23; 95% CI, 1.34-3.73; I = 78.2%), Clavien-Dindo IV complications (OR, 4.16; 95% CI, 1.70-10.17; I = 0%), adverse discharge (OR, 1.80; 95% CI, 1.15-2.84; I = 78.6%), and readmission (OR, 2.16; 95% CI, 1.19-3.91; I = 21.5%) in elderly trauma patients. Subgroup analysis showed that prospective studies (OR, 3.06; 95% CI, 1.43-6.56) demonstrated a greater correlation between frailty and postoperative complications. CONCLUSION: Frailty has significant adverse impacts on the occurrence of posttraumatic outcomes. Further studies should focus on interventions for patients with frailty. Given the number of vulnerable elderly trauma patients grows, further studies are needed to determine the accuracy of these measures in terms of trauma outcomes. LEVEL OF EVIDENCE: Systematic review and meta-analysis, level IV.

Generation of refractory schizophrenia patient-derived induced pluripotent stem cell line UJSi001-A.

Schizophrenia is considered one of the most serious mental disorders nowadays. Approximately 30-60% of people with schizophrenia do not present adequate response to drug treatment and persist with symptoms of the disease; they are known as refractory schizophrenic people. We generated induced pluripotent stem cells (iPSCs) from a refractory schizophrenia patient by electroporation of peripheral blood mononuclear cells (PBMC) with episomal plasmids encoding OCT 4, SOX 2, NANOG, LIN 28, KLF 4 and LMYC. The resulting iPSCs had normal karyotype, were free of genomically integrated episomal plasmids, expressed pluripotency markers, and could differentiate into the three germ layers in vivo.

Contribution of genes in the GABAergic pathway to bipolar disorder and its executive function deficit in the Chinese Han population.

In this study, we investigated the association between bipolar I disorder (BDI) and between cognitive deficits therein and SNPs in GABAergic receptor genes. The sample comprised 477 patients with BDI and 438 healthy controls, with three neurocognitive tests being administered in 123 patients and 164 controls. For three SNPs, rs505474, rs1398175, and rs4868029 in the GABRA2, GABRA4, and GABRP genes, respectively, their allele frequencies were significantly different between patients and controls (Bonferroni-adjusted p = values 3.84 × 10-4 , 9.92 × 10-3 , and 1.22 × 10-2 , respectively). Four haplotypes were significantly associated with BDI (TA and AG for rs3815762 and rs4868029 in GABRP, GG for rs11636988 and rs8024256 in GABRB3 and GAGG for rs2197414, rs4921195, rs13188991, and rs11956731 in GABRA6, with p values of 0.0038, 0.044, 0.0176, and 0.0267, respectively, on 10,000 permutations). Furthermore, the SNP (rs2912585) within 250 kb upstream of the GABRB3 gene displayed a strong association with the Tower of Hanoi (TOH) executive time in the patient group (p = 2.844 × 10-6 ). One other SNP (rs754661), which is located at the intronic region of the same gene, was associated with the global trait of the executive function and post hoc analysis showed significant SNP by group effect (p = 0.0094). Our study supports previous findings that GABAA receptor genes are associated with bipolar disorder; it also suggests that the GABAA genes, especially the GABRB3 gene, might play a role in the executive function deficit in bipolar disorder, although future replication with a larger sample size is needed.

[Association of the DJ-1 gene polymorphism with sporadic Parkinson's disease in Sichuan province of China].

OBJECTIVE: To investigate the frequencies of three polymorphisms in DJ-1 (g.168-185del; SNP405, refSNP ID:rs3766606 and 293 G/A) and their association with sporadic Parkinson's disease. METHODS: An association study was performed to determine the genotype of each subject using polymerase chain reaction, restriction fragment length polymorphism and sequence analysis in 192 patients with sporadic Parkinson's disease and 198 healthy controls. RESULTS: In the g.168-185del locus, the Ins/Ins genotype was common and the frequency of Del allele was very low (0.38%). The SNP of 293G/A was not detected in both groups. In the SNP405 G/T site, the GT genotype frequency was significantly higher in patients with age of onset before 40 years than in controls (18.75% vs 5.54%, P=0.004, OR=6.30 95%CI:1.96-20.18). CONCLUSION: The results suggest that the frequencies of the g.168-185del and 293G/A polymorphisms might be different between Chinese and European. The SNP405 GT genotype might be a risk factor for sporadic Parkinson's disease with early age of onset in Sichuan Han population.