ABSTRACT
The hypoglycaemic effect of aqueous leaf extract of Murraya koenigii was studied in normal and alloxan-induced diabetic rats. The extract was administered orally at 100 mg/Kg, 150 mg/Kg and 200 mg/Kg bodyweight each to respective groups of animals (Groups I, II and III) for seven days. Group IV received normal saline and served as control for the normal rats. For the alloxan-induced diabetic rats, the same dosage pattern was administered to three groups of rats for seven days (Groups V, VI and VII) while group VIII which received normal saline served as control. At the various dose levels administered, the glucose lowering effect was more pronounced in the alloxan-diabetic rats than in control rats. When compared with chlorpropamide, the glucose lowering effect of aqueous extract of Murraya koenigii was significantly (p < 0.05) lower at the dose levels administered in both normal and alloxan-diabetic rats.
Subject(s)
Blood Glucose/drug effects , Diabetes Mellitus, Experimental/drug therapy , Hypoglycemic Agents/pharmacology , Hypolipidemic Agents/pharmacology , Lipids/blood , Murraya , Plant Preparations/pharmacology , Administration, Oral , Animals , Chlorpropamide/pharmacology , Diabetes Mellitus, Experimental/blood , Dose-Response Relationship, Drug , Hypoglycemic Agents/isolation & purification , Hypolipidemic Agents/isolation & purification , Male , Murraya/chemistry , Plant Leaves , Plant Preparations/isolation & purification , RatsABSTRACT
The effect of the extract of Cucumis metuliferus fruit on some male reproductive parameters was investigated in albino rats. The LD50 of the extract was above 5000 mg/kg body weight when administered orally. Histological studies showed that there was no remarkable change in the testes histology compare to the control. The effects on sperm cells showed a statistically significant (P0.05) increase in total sperm count with an insignificant (P0.05) increase in viability count in rats treated with 500 mg/kg dose point. On the other hand; 1000 mg/kg dose point produced significant (P0.05) decrease in total sperm count and viability count compare to control. This result suggests that C. metuliferus fruit extracts could be beneficial in increasing sperm/semen integrity
