ABSTRACT
This case report describes the clinical and postmortem findings in a 2.5-year-old goat with necrotizing granulomatous pneumonia. The goat was referred to our clinic because of swelling of the head and neck, which was unresponsive to treatment, dysphagia, and deterioration in general condition. Thoracic radiographs showed two soft tissue densities, about 10 cm in diameter, in the left caudodorsal lung. The goat was euthanized and a necropsy was carried out. The two lesions in the left caudodorsal lung were round, firm and clearly demarcated from the surrounding lung tissue. They contained purulent material and compromised about 70 % of the diaphragmatic lung lobe. Histological examination of the lesions revealed a dense network of hyphae characteristic of Mucorales spp.
Subject(s)
Goats , Pneumonia , Animals , LungSubject(s)
Ultrasonography/veterinary , Urachus/diagnostic imaging , Urachus/injuries , Animals , Ascites/diagnosis , Ascites/etiology , Ascites/veterinary , Blood Urea Nitrogen , Cattle , Creatinine/blood , Fatal Outcome , Female , Hematocrit/veterinary , Pregnancy , Treatment Outcome , Ultrasonography/methods , Urachus/surgery , Urinary Bladder/diagnostic imaging , Urinary Bladder/injuriesSubject(s)
Cattle Diseases/diagnosis , Cattle Diseases/surgery , Dentigerous Cyst/veterinary , Jaw Neoplasms/veterinary , Tooth, Unerupted/veterinary , Animals , Animals, Newborn , Cattle , Cattle Diseases/diagnostic imaging , Cattle Diseases/pathology , Cutaneous Fistula/pathology , Cutaneous Fistula/veterinary , Dentigerous Cyst/diagnosis , Dentigerous Cyst/surgery , Diagnosis, Differential , Female , Jaw Neoplasms/diagnosis , Jaw Neoplasms/surgery , Radiography , Tooth Extraction/veterinary , Tooth, Unerupted/diagnosis , Tooth, Unerupted/surgeryABSTRACT
Intramuscular (i.m.) administration of medetomidine (MED) may avoid the severe pressor effects caused by peripheral actions of MED associated with intravenous (i.v.) dosing. The purpose of this study was to determine the pharmacokinetics, the time course of sedation and occurence of hypoxaemia after i.m. administration of MED in domestic sheep. The MED was injected i.m. at a dose of 30 micro g/kg in nine domestic sheep. Blood was sampled at 0, 5, 10, 20, 30, 40, 60, 120, 180, 240, 360 and 600 min after MED. Sedation was assessed and arterial blood samples were taken before and 35 min after MED application. Mean (SD) pharmacokinetic parameters of i.m. MED were: absorption half-life: 13.2 (7.5) min; terminal half-life: 32.7 (14.9) min; time to peak concentration: 29.2 (8.9) min; peak concentration: 4.98 (1.89) ng/mL; volume of distribution: 3.9 (2.4) l/kg; total body clearance: 81.0 (21.5) mL/(min kg). Peak sedation occurred between 30 and 40 min after injection of MED. The degree of sedation correlated with individual plasma concentrations (rS: 0.926). One animal became hypoxaemic (PaO2 = 54.1 mmHg).
