[Changes in the level of free fatty acids in patients with acute alcoholic hepatitis]. / Veränderungen des Spiegels der freien Fettsäuren bei Patienten mit akuter alkoholischer Hepatitis.

The study covered 25 patients with acute alcoholic hepatitis mean age of 48 years 25 patients with alcoholic liver steatosis (mean age of 49 years), and 41 clinically healthy persons - controls (mean age of 42 years). Plasma levels of individual free fatty acids (FFA) were determined in any case. There was a statistically significant decrease of palmitinc, stearinic, oleinic, linolic and arachidonic acid and of total FFA in the patients with acute alcoholic hepatitis (AAH) as compared with the controls (p less than 0.001). Similar changes were found in patients with liver steatosis but they were slightlier expressed. In AAH patients serious disorders of FFA metabolism set in which are manifested mainly by total FFA level reduction that is on the account of the polyunsaturated fatty acids combined with significant increase of the saturated ones.

[Late toxicosis, disseminated intravascular coagulation disorders and acute fatty liver during pregnancy (Sheehan's disease II)]. / Spättoxikose, DIG und akute Fettleber der Schwangerschaft. (M. Sheehan II).

The authors discuss some etiologic and clinical aspects of M. Sheehan II based on 2 histologically proven cases. They point out the consecutive connection between the preeclampsia, DIG and the development of the syndrom. The role as starters of some medicaments beside other factors is suggested. The paramount importance of an immediate diagnosis and adequate and correct therapeutic measures, which include a prompt interruption of pregnancy and treatment of the acid-base dysbalance, the renal and haematologic failure is stressed, as well as the prophylactic measures.