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1.
Ophthalmic Epidemiol ; 26(5): 295-300, 2019 10.
Article in English | MEDLINE | ID: mdl-31025588

ABSTRACT

Purpose:To examine the association between dry eye and diabetes mellitus among a large North Carolina patient population. Methods:A retrospective cross-sectional study of patients seen within the University of North Carolina medical system between July 1, 2008, and September 1, 2017, was performed. De-identified medical records contained within the Carolina Data Warehouse of adult patients who have had an ocular evaluation were studied. Four categories of disease states were identified by ICD-9 and ICD-10 codes. Patients were grouped based on being diagnosed with Dry Eye Disease (ICD-9: 375.15, 370.33, and ICD-10: H04.12, H16.221), Diabetes Mellitus (ICD-9: 250.00-250.93 and ICD-10: E08-E11, E13), neither, or both diseases. Odds ratios of the association between diabetes and dry eye were calculated for the following racial/ethnic groups: Non-Hispanic White, Non-Hispanic Black/African American, Asian, and Hispanic. Results:A total of 81,480 patients were included in the analysis; of those, 8978 patients had dry eye disease and 18,361 patients had diabetes. The remaining 54,141 patients had neither disease. Dry eye prevalence among patients with diabetes was 14.39% (95% CI: 13.89-14.91%) and 10.11% (95%CI: 9.88-10.35%) among patients without diabetes. The odds of a patient with diabetes having dry eye are 1.15 (95% CI: 1.09-1.21) times that of a patient without diabetes. Asian patients with diabetes demonstrated the highest odds of having dry eye at 1.49 (95% CI: 1.12-1.98). Conclusions:Dry eye is common among patients with diabetes, and the association between these diseases is strongest among Asian patients. Race and ethnicity are important demographic factors that may guide providers in the diagnosis and treatment of dry eye in the setting of diabetes.


Subject(s)
Diabetes Mellitus/ethnology , Dry Eye Syndromes/ethnology , Ethnicity , Racial Groups , Adolescent , Adult , Aged , Cross-Sectional Studies , Female , Health Services Accessibility , Healthcare Disparities , Humans , Male , Middle Aged , North Carolina/epidemiology , Odds Ratio , Prevalence , Retrospective Studies , Young Adult
2.
J AAPOS ; 22(1): 81-82, 2018 02.
Article in English | MEDLINE | ID: mdl-29288840

ABSTRACT

A 2 day-old-girl with a complicated birth history, including prolonged rupture of membranes and Caesarian section delivery, presented with a purulent bacterial conjunctivitis of the left eye despite standard prophylaxis. Bacterial cultures yielded 1+ Morganella morganii, a facultative anaerobe and a rare cause of ocular pathology. The patient was treated with topical tobramycin four times daily for 7 days, resulting in resolution of her conjunctivitis.


Subject(s)
Conjunctivitis, Bacterial/microbiology , Enterobacteriaceae Infections/diagnosis , Morganella/isolation & purification , Ophthalmia Neonatorum/microbiology , Anti-Bacterial Agents/therapeutic use , Female , Humans , Infant, Newborn , Tobramycin/therapeutic use , Treatment Outcome
3.
World J Surg Oncol ; 14(1): 227, 2016 Aug 26.
Article in English | MEDLINE | ID: mdl-27561329

ABSTRACT

BACKGROUND: Osteoclast-like giant cells (OLGCs) are a rare histologic finding within a tumor of the breast. Although there has been discussion as to the pathogenesis and prognosis related to this finding, our understanding of its significance remains inconclusive. Clear cells are another unique histologic finding in breast tumors and are typically associated with tumors arising in other organs such as renal cell carcinoma. CASE PRESENTATION: This is a case report of a 64-year-old female who presented with one tumor identified as invasive ductal carcinoma with a combination of OLGCs and clear cell features. CONCLUSIONS: To our knowledge, this combination of findings has not been previously described in the literature and therefore represents another morphologic manifestation of breast carcinoma. As patients are diagnosed earlier and live longer, a growing number of these rare variants may be recognized and provide opportunities to further our understanding of the associated molecular pathways which could contribute to the possibility of therapeutic intervention.


Subject(s)
Breast Neoplasms/diagnosis , Breast Neoplasms/pathology , Carcinoma, Ductal, Breast/diagnosis , Carcinoma, Ductal, Breast/pathology , Giant Cells/pathology , Osteoclasts/pathology , Biopsy, Large-Core Needle , Breast/diagnostic imaging , Breast/pathology , Breast Neoplasms/diagnostic imaging , Carcinoma, Ductal, Breast/diagnostic imaging , Female , Humans , Image-Guided Biopsy , Immunohistochemistry , Mammography , Middle Aged , Neoplasm Invasiveness , Prognosis , Rare Diseases/diagnosis , Rare Diseases/diagnostic imaging , Rare Diseases/pathology , Ultrasonography, Mammary
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