An overview of pediatric obesity.

Pediatric obesity is increasing worldwide and disproportionately affects the economically and socially disadvantaged. Obese children are at risk of developing the (dys)metabolic syndrome, insulin resistance, early-onset type 2 diabetes mellitus, polycystic ovarian syndrome, hypertension, hyperlipidemia, and obstructive sleep apnoea. Those with diabetes may have mixed features of type 1 and type 2 diabetes mellitus. Pediatric obesity is the result of persistent adverse changes in food intake, lifestyle, and energy expenditure. It may be because of underlying a genetic syndrome or a conduct disorder. Children living in urban settings often lack safe, affordable, and accessible recreational facilities. Tight educational schedules mean less free time, while computer games and television have become preferred recreational activities. More families are eating out or eating take-out meals and processed foods at home because of pressures of work and time constraints. Consumer advertising targeted at children and the ready availability of vending machines encourage unwise food choices. Some children eat excessively because they are depressed, anxious, sad, or lonely. Often families and obese children are aware of the need for healthy eating and exercise but are unable to translate knowledge into weight loss. Population-based measures such as public education, school meal reforms, child-safe exercise friendly environments, and school-based and community-based exercise programs have been shown to be successful to varying degrees, but there remain individuals who will need special help to overcome obesity. Overeating (e.g. binge eating) may be a manifestation of disordered coping behavior but may also be because of defects in the neural and hormonal control of appetite and satiety. New pharmacological approaches are targeting these areas. We need a coordinated approach involving government, communities, and healthcare providers to provide a continuum of population-based interventions, focused screening, and personalized multidisciplinary interventions for the obese child and family.

Experiments with active phase matching of parallel-amplified Multiline HF laser beams by a phase-locked Mach-Zehnder interferometer.

Active phase matching of multiline HF laser beams by means of a phase-locked Mach-Zehnder interferometer was demonstrated by locking the interferometer to the central interference fringe at zero optical path length difference. The central fringe could be found by varying the spectral content of the input beam. Laser amplification in one leg of the interferometer decreased fringe visibility without adversely affecting locking. Single-line fringe patterns produced by an array spectrometer (while the interferometer was operated in its scanning mode) were analyzed to show that no significant dispersion occurred in the amplifier. The techniques developed have potential for measuring dispersion mismatch between larger parallel amplifiers. These experiments demonstrated in principle that a number of multiline HF amplified beams can be recombined and phase-matched to produce a high beam quality output beam.

Stapedius reflex decay in myasthenia gravis.

Stapedius reflex decay, in response to a one-minute sound stimulus of 500 Hz occurred in six patients with myasthenia gravis. This decay is analagous to the decremental response of muscle action potentials to rapid nerve stimulation. Edrophonium chloride decreases the degree of decay. This represents a useful test in the diagnosis of myasthenia gravis.